Navigation Links
Females fend off gut diseases

EAST LANSING, Mich. --- At least among mice, females have innate protection from certain digestive conditions, according to a new Michigan State University study.

While it's tricky to draw conclusions for human health, the findings could eventually help scientists better understand and treat the 1.4 million Americans suffering from inflammatory bowel diseases, or IBD.

Crohn's disease and colitis, the two most common forms of IBD, involve abnormal functioning of the immune system that can damage the digestive tract, causing inflammation, diarrhea, constipation, abdominal pain and other symptoms.

For the study, researchers induced colitis by giving mice with weakened immune systems a dose of bacteria that can cause digestive trouble. After six weeks, the males had significantly more severe symptoms than the females and had more of the bacteria left in their guts. The males also showed more deterioration of their bones, which studies have linked to gut inflammation.

"It seems females are protected from bad bacteria-induced bone loss, and it's because they have reduced gut inflammation," said co-author Laura McCabe, a professor in the MSU Departments of Physiology and Radiology. "When we looked at markers of inflammation in the male mice, they were really high, whereas the females didn't have that kind of bad response. They can somehow handle these nasty bacteria."

McCabe said while the new study is a step toward better understanding of IBD, it's not clear if women have the same kind of resistance to the condition as the female mice. Indeed, much is still unknown about IBD, including what causes it. The imbalance of good and bad gut bacteria that the experiment simulated is one possible cause.

"We want to know what it is about female mice allowing them to be protected," she said. "If we can understand that, we might have a potential therapeutic target for people with IBD."


Contact: Andy McGlashen
Michigan State University

Page: 1

Related biology news :

1. Environmental change impacts on migratory shorebirds differ for males and females
2. Females tagged in wasp mating game
3. Peacock love songs lure eavesdropping females from afar
4. Team discovers reason that male moths can keep finding females
5. Stem cell study could aid quest to combat range of diseases
6. Janssen, J&J Innovation, VIB, KU Leuven and UZ Leuven join forces to combat neurological diseases
7. Study explores 100 year increase in forestry diseases
8. Renaissance in new drugs for rare diseases
9. Renaissance in new drugs for rare diseases: Report in worlds largest scientific socity magazine
10. OHSU teams with Intel to decode the root causes of cancer and other complex diseases
11. Discovery may explain how prion diseases spread between different types of animals
Post Your Comments:
(Date:11/17/2015)... , November 17, 2015 ... 19 novembre  2015.  --> Paris , ... --> DERMALOG, le leader de l,innovation biométrique, a ... fois passeports et empreintes sur la même surface de ... passeports et l,autre pour les empreintes digitales. Désormais, un ...
(Date:11/17/2015)... 17, 2015 Pressure BioSciences, Inc. (OTCQB: PBIO) ... and sale of broadly enabling, pressure cycling technology ("PCT")-based ... today announced it has received gross proceeds of $745,000 ... Placement (the "Offering"), increasing the total amount raised to ... additional closings are expected in the near future. ...
(Date:11/12/2015)... 2015  A golden retriever that stayed healthy despite ... has provided a new lead for treating this muscle-wasting ... Institute of MIT and Harvard and the University of ... Cell, pinpoints a protective gene that ... effects. The Boston Children,s lab of Lou Kunkel ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... November 25, 2015 2 nouvelles études ... les différences entre les souches bactériennes retrouvées dans ... des êtres humains . Ces recherches  ouvrent une ... la prise en charge efficace de l,un des ... les chats .    --> 2 nouvelles ...
(Date:11/25/2015)... ... 2015 , ... A long-standing partnership between the Academy of ... formalized with the signing of a Memorandum of Understanding. , AMA Executive Director ... Minter and Capt. Albert Glenn Tuesday, November 24, 2015, at AMA Headquarters in ...
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf Association (USGA) ... USGA Green Section Award. Presented annually since 1961, the USGA Green Section Award recognizes ... with turfgrass. , Clarke, of Iselin, N.J., is an extension specialist of ...
(Date:11/24/2015)... ... 24, 2015 , ... International Society for Pharmaceutical Engineering (ISPE) ... annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The conference took place in ... largest number of attendees in more than a decade. , “The 2015 ...
Breaking Biology Technology: