Navigation Links
Females fend off gut diseases

EAST LANSING, Mich. --- At least among mice, females have innate protection from certain digestive conditions, according to a new Michigan State University study.

While it's tricky to draw conclusions for human health, the findings could eventually help scientists better understand and treat the 1.4 million Americans suffering from inflammatory bowel diseases, or IBD.

Crohn's disease and colitis, the two most common forms of IBD, involve abnormal functioning of the immune system that can damage the digestive tract, causing inflammation, diarrhea, constipation, abdominal pain and other symptoms.

For the study, researchers induced colitis by giving mice with weakened immune systems a dose of bacteria that can cause digestive trouble. After six weeks, the males had significantly more severe symptoms than the females and had more of the bacteria left in their guts. The males also showed more deterioration of their bones, which studies have linked to gut inflammation.

"It seems females are protected from bad bacteria-induced bone loss, and it's because they have reduced gut inflammation," said co-author Laura McCabe, a professor in the MSU Departments of Physiology and Radiology. "When we looked at markers of inflammation in the male mice, they were really high, whereas the females didn't have that kind of bad response. They can somehow handle these nasty bacteria."

McCabe said while the new study is a step toward better understanding of IBD, it's not clear if women have the same kind of resistance to the condition as the female mice. Indeed, much is still unknown about IBD, including what causes it. The imbalance of good and bad gut bacteria that the experiment simulated is one possible cause.

"We want to know what it is about female mice allowing them to be protected," she said. "If we can understand that, we might have a potential therapeutic target for people with IBD."


Contact: Andy McGlashen
Michigan State University

Page: 1

Related biology news :

1. Environmental change impacts on migratory shorebirds differ for males and females
2. Females tagged in wasp mating game
3. Peacock love songs lure eavesdropping females from afar
4. Team discovers reason that male moths can keep finding females
5. Stem cell study could aid quest to combat range of diseases
6. Janssen, J&J Innovation, VIB, KU Leuven and UZ Leuven join forces to combat neurological diseases
7. Study explores 100 year increase in forestry diseases
8. Renaissance in new drugs for rare diseases
9. Renaissance in new drugs for rare diseases: Report in worlds largest scientific socity magazine
10. OHSU teams with Intel to decode the root causes of cancer and other complex diseases
11. Discovery may explain how prion diseases spread between different types of animals
Post Your Comments:
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, ... microbial test has received AOAC Research Institute approval 061601. , “This is another ... year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel ...
(Date:6/23/2016)... ... ... Supplyframe, the Industry Network for electronics hardware design and ... in Pasadena, Calif., the Design Lab’s mission is to bring together inventors and ... brought to market. , The Design Lab is Supplyframe’s physical representation of one ...
Breaking Biology Technology: