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Female mice exposed to BPA by mothers show unexpected characteristics
Date:1/24/2013

s and lead author on the paper published online in the Journal of the Federation of American Societies for Experimental Biology.

"There are several things we need to look at in evaluating studies investigating BPA as an obesogen, such as composition of the diet. Not all these diets are similar throughout these studies. Some may have high-fat diets. Some may have diets with different protein levels. Then there is the difference in exposure timing and doses of exposure of BPA. It's important to dig a little deeper and actually look at the mechanism that BPA is acting upon."

As to why only females exhibited the excessive activity and lean bodies, Dolinoy says it bears more study, but because BPA is known to impact estrogen and thyroid hormone, most likely it is affecting these natural hormones in the females.

Dolinoy's lab is dedicated to the study of environmental epigenetics and nutritionlearning about how exposure to chemical, nutritional and behavioral factors alters gene expression and impacts health and disease.

In December, she and colleagues released a study that found BPA in human fetal liver tissue, demonstrating that there is considerable exposure to the chemical during pregnancy. That research also found that the BPA in fetuses was in a form not eliminated from the body, unlike previous studies that showed adult humans metabolize and rid their bodies of the chemical.

Her work is supported by the U-M Formative Children's Environmental Health and Disease Prevention Center (UM-CEHC) and the U-M Michigan Nutrition and Obesity Research Center (MNORC). MNORC receives funding from the National Institutes of Health, and UM-CEHC from the NIH and the Environmental Protection Agency.

"The work that Olivia Anderson carried out in Dr. Dolinoy's lab is really at the heart of some of the most pressing questions we're trying to solve right now, and their work was a great fit for both centers because it asks a
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Contact: Laurel Thomas Gnagey
ltgnagey@umich.edu
734-647-1841
University of Michigan
Source:Eurekalert

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