Navigation Links
Female mice exposed to BPA by mothers show unexpected characteristics

ANN ARBORFemale mice exposed to Bisphenol A through their mother's diet during gestation and lactation were found to be hyperactive, exhibit spontaneous activity and had leaner body mass than those not exposed to the chemical, researchers at the University of Michigan School of Public Health have discovered.

BPA is a chemical most commonly found in the lining of food cans and cash register receipts. It once was in many hard plastic bottles, including baby bottles, but many companies have removed it as concerns about exposure have come to light in recent years.

These latest findings from U-M researchers seem to contradict previous studies on BPA that found the chemical to be a factor in obesity. But Dana Dolinoy, the John G. Searle Assistant Professor of Environmental Health Sciences and senior/corresponding author of the study, says research shows that many factors impact how the body reacts to the chemical.

"Our hypothesis going into this study was that BPA would act as an obesogenic agent. And there is some preliminary evidence that it does," Dolinoy said. "But there are differences in exposure, duration and when you actually measure the individual.

"Recent evidence in humans only looks at one time point. What we're really interested in is BPA exposure during early development, and how that affects health throughout life. So those are two very different questions."

The researchers exposed mothers to three different levels of BPA in the diet then followed the offspring through adulthood at three, six and nine months of age. The average lifespan of a mouse is two years, so by three months they are young adults.

"We looked at several different metabolic phenotypes, including spontaneous activity, food intake, energy expenditure and body composition. I think the most striking result we saw was the increased activity in these animals," said Olivia Anderson, doctoral student in environmental health sciences and lead author on the paper published online in the Journal of the Federation of American Societies for Experimental Biology.

"There are several things we need to look at in evaluating studies investigating BPA as an obesogen, such as composition of the diet. Not all these diets are similar throughout these studies. Some may have high-fat diets. Some may have diets with different protein levels. Then there is the difference in exposure timing and doses of exposure of BPA. It's important to dig a little deeper and actually look at the mechanism that BPA is acting upon."

As to why only females exhibited the excessive activity and lean bodies, Dolinoy says it bears more study, but because BPA is known to impact estrogen and thyroid hormone, most likely it is affecting these natural hormones in the females.

Dolinoy's lab is dedicated to the study of environmental epigenetics and nutritionlearning about how exposure to chemical, nutritional and behavioral factors alters gene expression and impacts health and disease.

In December, she and colleagues released a study that found BPA in human fetal liver tissue, demonstrating that there is considerable exposure to the chemical during pregnancy. That research also found that the BPA in fetuses was in a form not eliminated from the body, unlike previous studies that showed adult humans metabolize and rid their bodies of the chemical.

Her work is supported by the U-M Formative Children's Environmental Health and Disease Prevention Center (UM-CEHC) and the U-M Michigan Nutrition and Obesity Research Center (MNORC). MNORC receives funding from the National Institutes of Health, and UM-CEHC from the NIH and the Environmental Protection Agency.

"The work that Olivia Anderson carried out in Dr. Dolinoy's lab is really at the heart of some of the most pressing questions we're trying to solve right now, and their work was a great fit for both centers because it asks and answers questions that are right at the intersection of how toxicants effect health, particularly related to obesity," said Karen Peterson, professor of environmental health sciences at the U-M School of Public Health, director of the CEHC and associate director of MNORC.

Contact: Laurel Thomas Gnagey
University of Michigan

Related biology news :

1. Highly exposed to phthalates as fetuses, female mice have altered reproductive lives
2. Study: Exercise can lead to female orgasm, sexual pleasure
3. Queens is UK leader for female scientists and engineers
4. UCSB researchers find that less is more, for female cowbirds
5. Team discovers reason that male moths can keep finding females
6. Traumatic mating may offer fitness benefits for female sea slugs
7. Peacock love songs lure eavesdropping females from afar
8. Females tagged in wasp mating game
9. Men more likely to commit research misconduct than female counterparts
10. Children exposed to the common pollutant naphthalene show signs of chromosomal damage
11. Infants exposed to specific molds have higher asthma risk
Post Your Comments:
(Date:10/29/2015)... Oct. 29, 2015  Rubicon Genomics, Inc., today ... distribution of its DNA library preparation products, including ... new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has been ... of NGS libraries for liquid biopsies--the analysis of ... prognostic applications in cancer and other conditions. Eurofins ...
(Date:10/29/2015)... , Oct. 29, 2015 Today, ... announced a partnership with 2XU, a global leader ... deliver a smart hat with advanced bio-sensing technology. ... other athletes to monitor key biometrics to improve ... strategic partnership, the two companies will bring together the ...
(Date:10/27/2015)... Calif. , Oct. 27, 2015 Synaptics Inc. ... solutions, today announced that Google has adopted the Synaptics ... touch controller solutions to power its newest flagship smartphones, ... by Huawei. --> ... like Google to provide strategic collaboration in the joint ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( ), finds that the market earned ...
(Date:11/24/2015)... ... 24, 2015 , ... Copper is an essential micronutrient that ... proteins, copper is also toxic to cells. With a $1.3 million award from ... conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions leader SAP and ... to develop and pitch their BIG ideas to improve health and wellness in their ... votes to win the title of SAP's Teen Innovator, an all-expenses paid trip to ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris ... today that the remaining 11,000 post-share consolidation (or ... Warrants (the "Series B Warrants") subject to the ... on November 23, 2015, which will result in ... giving effect to the issuance of such shares, ...
Breaking Biology Technology: