Navigation Links
Female human embryos adjust the balance of X chromosomes before implantation
Date:6/29/2009

Amsterdam, The Netherlands: Dutch researchers have found the first evidence that a process of inactivating the X chromosome during embryo development and implantation, which was known to occur in mice but unknown in humans, does, in fact, take place in human female embryos prior to implantation in the womb.

Ms Ilse van den Berg told the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam today (Monday) that her findings may have implications for the laboratory cultures that embryos are grown in before transfer to a woman's womb during fertility treatment, as well as for embryo stem cell research.

Males and females have two sex chromosomes: X and Y. While females have two X chromosomes and no Y chromosome, males have one of each. As the X chromosome is much larger then the Y chromosome, males and females also differ in their numbers of genes and gene expression. To equalise this difference in gene expression, females need to silence one X chromosome in every cell a process known as X chromosome inactivation (or XCI).

In mice, XCI occurs before embryo implantation when the X chromosome inherited from the father is turned off, while the maternal X chromosome remains turned on. As the cells carry on dividing and reach the blastocyst stage, the cells that will go on to form the placenta continue to have the paternal X chromosome switched off, but it is switched back on in the cells that are going to form the inner cell mass that develops into the foetus.

"It is from these cells that mice embryonic stem cell lines are made; these ES cells have two active X chromosomes and are capable of becoming any kind of cell in the body. As soon as the cells are going to differentiate into any kind of specialised cell, one X chromosome is turned off again, but this time it is a random process and it can be either the maternal or paternal X chromosome that is switched off," explained Ms van den Berg,
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Sex is thirst-quenching for female beetles
2. UT Southwestern researchers identify hundreds of genes controlling female fertility
3. Why do males and females frequently differ in body size and structure?
4. X-effect: female chromosome confirmed a prime driver of speciation
5. Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows
6. Gene in male fish lures females into sex
7. New evidence for female control in reproduction
8. Men unaware of their cancer risk when female relatives test positive for BRCA mutation
9. How do you know whether you are male or female?
10. Female katydids prefer mates cool in winter and hot in summer
11. Female concave-eared frogs draw mates with ultrasonic calls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... Calif. , Aug. 5, 2015 The ... continuous growth in applications, penetration into newer sectors, and ... year. The global biosensors space has seen the entry ... the market so far. (Photo - ... & Sullivan, Analysis of the Global Biosensors Market ...
(Date:8/3/2015)... 3, 2015 Synaptics, Inc. (Nasdaq: SYNA ... announced that members of the executive management team will ... Global Technology Leadership Forum on Tuesday, August 11, 2015 ... held at the Sonnenalp Resort in Vail, ... include forward-looking information. An audio webcast of the event ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julho de 2015 ... Genômica (ICG-10, www.icg-10.org ) será realizada pela BGI de ... China . A conferência está ... inauguração em 2006, a ICG se tornou uma das ... e um dos encontros científicos mais dinâmicos, entusiastas e ...
Breaking Biology News(10 mins):Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... Office has granted an exclusive license of a novel ... Inc., which plans to initiate early-stage human clinical trials ... Gary Landreth, PhD, the Riuko and Archie G. Co ... PhD, co-founded ReXceptor after discovering that bexarotene (a medication ...
... and Oxford, UK Cancer cells are a problem for ... blithely metastasize to set up shop in places where they ... this way is a tumor suppressor named p53. This protein ... those that are damaged beyond repair. Not surprisingly, p53,s critical ...
... across the UK has shown a grass hybrid species ... The BBSRC-funded scientists, from Rothamsted Research, the James Hutton ... at Aberystwyth University, Lancaster University and the University of ... perennial ryegrass ( Lolium perenne ) with a closely ...
Cached Biology News:Research spinoff ReXceptor gets license for Alzheimer's treatment 2Reviving a foe of cancer 2New grass hybrid could help reduce the likelihood of flooding 2
(Date:8/31/2015)... ... August 31, 2015 , ... There’s a new treatment option for excessive menstrual ... available new FDA approved system in the last 14 years, and the only endometrial ... (zero bleeding) rate of 66%, the high Patient Satisfaction rate of 98%, and the ...
(Date:8/30/2015)... , England , August 31, 2015 ... die 51-jährige Wartezeit   einer Frau   für chirurgische ... im Alter von 7-90   werden für ... Programm soll 1200 Frauen behandeln und die Anzahl ... Astellas gab heute bekannt, dass  ...
(Date:8/28/2015)... , August 28, 2015 ... Product (Media, Sera, Cryogenic Storage Systems, Thawing Equipment, Alarms), ... Regenerative Medicine, Clinical Trials), End User - Global Forecast ... is expected to reach USD 3,731.03 Million by 2020 ... CAGR of 11.65% between 2015 and 2020. ...
(Date:8/28/2015)... ... August 28, 2015 , ... Pittcon is ... will present a session on chemical spectroscopic imaging at JASIS 2015 (Japan Analytical ... Asia’s largest analytical and scientific instruments show which will be held at International ...
Breaking Biology Technology:U.S. FDA Approves Minerva Endometrial Ablation System 2U.S. FDA Approves Minerva Endometrial Ablation System 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 2U.S. Symposium on Imaging Organized by Pittcon’s Program Chairman Chuck Gardner 3
... , , , , ... Imagenetix, Inc. (OTC Bulletin Board: IAGX) announced today results for its first fiscal ... from the $1,394,000 reported for the same period last year. , ... compared to a net profit for the same period of the prior fiscal year ...
... , , , LEXINGTON, ... for Genome Resources (NCGR) has selected febit,s DNA-capture method, HybSelect(TM), ... of the most devastating childhood diseases with the ultimate goal ... genetic diseases in prospective parents. , , ...
... and VANCOUVER, Aug. 10 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, ... that the United States Patent and Trademark Office ... entitled "Chemo-and Radiation-sensitization of Cancer by Antisense TRPM-2 ... cancer drug candidate, OGX-011, to treat certain cancers. ...
Cached Biology Technology:Imagenetix, Inc. Reports First Quarter 2010 Results 2Imagenetix, Inc. Reports First Quarter 2010 Results 3Imagenetix, Inc. Reports First Quarter 2010 Results 4Imagenetix, Inc. Reports First Quarter 2010 Results 5The National Center for Genome Resources Studies Childhood Diseases Using febit's DNA Capture Method 2The National Center for Genome Resources Studies Childhood Diseases Using febit's DNA Capture Method 3OncoGenex Pharmaceuticals Announces Issuance of Key Patent for OGX-011 2OncoGenex Pharmaceuticals Announces Issuance of Key Patent for OGX-011 3
... short-term enriched housing for nonhuman primates and ... non-quarantine settings on a per diem basis. ... state-of-the-art social housing and nursery facilities. In ... CDC quarantine facilities. Primate housing and ...
... nucleic acid gel stain has bright fluorescence when ... making it ideal for detecting dsDNA in gels ... SYBR Green I nucleic acid stain has ... PCR assays and bandshift assays. A 500 µL ...
Synonym: modified Grace's Insect medium...
Schneider's Drosophila - Insect medium...
Biology Products: