Navigation Links
Feline virus, antiviral drug studied to understand drug resistance
Date:10/10/2007

COLUMBUS , Ohio Researchers at Ohio State will spend the next two years testing their theories about just how an AIDS-like virus in cats is able to resist the powerful medicines that are thrown against it.

It's one of the latest efforts at understanding one of the leading problem areas in medicine today -- antimicrobial drug resistance. When bacteria or viruses become resistant to drugs, they become more difficult, or even impossible, to treat.

The project, funded by the National Institute on Drug Abuse, could reveal how some viral infections become able to withstand antiviral medications and even thrive in the presence of some drugs.

If successful, the research might pave the way to smarter, more effective treatments for a host of pathogens that have learned to resist most therapeutic efforts.

The project grew from important discoveries made five years ago as part of a controversial research program investigating the impact of methamphetamine on feline immunodeficiency virus (FIV) one of only three animal viruses that can be used to mimick HIV (human immunodeficiency virus) infections in humans.

Surprisingly, that project showed that the virus was able reproduce itself 15 times faster when methamphetamine was present.

The work also showed that FIV mutated rapidly to adapt to grow in astrocytes, the dominant cell type within the brain, and that this phenomenon was accelerated by exposure to methamphetamine.

That observation led to an epiphany of sorts, explained Lawrence Mathes, professor of veterinary biosciences and associate dean for research and graduate studies in the College of Veterinary Medicine and principal investigator on the project.

If the virus becomes drug-resistant as it routinely mutates into this new form, would that drug resistance occur earlier if methamphetamine were present" he asked.

After an initial phase five years ago that used cats as the anim
'/>"/>

Contact: Earle Holland
holland.8@osu.edu
614-292-8384
Ohio State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Philandering female felines forgo fidelity
2. Norovirus, AIDS vaccine and Hepatitis Virus
3. Novel antiviral technology inhibits RSV infection in mice
4. Biota makes major antiviral discovery
5. New possibilities for flu antiviral and vaccine research emerge from Spanish flu virus
6. The reason why antiviral therapy cant annihilate HIV infection, and what to do about it
7. Bird flu -- Call for antiviral drugs to be shared
8. Antivirals effectively curb influenza virus
9. Use of high hydrostatic pressure to inactivate Hepatitis A virus in oysters studied
10. Saharas edge studied from ground, air and space to improve water management
11. Inflammation and drugs to control this activity studied in a variety of tumors sites
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2015)... Mass., July 23, 2015 Aware, Inc. (NASDAQ: ... today reported financial results for its second quarter ended June ... of 2015 was $4.5 million, a decrease of 33% compared ... income in the second quarter of 2015 was $0.3 million, ... or $0.04 per diluted share, in the same period a ...
(Date:7/20/2015)... , July 20, 2015  Acuity Market Intelligence,s ... The Convergence of Commerce and Privacy" forecasts that ... biometric apps will be downloaded to smart mobile ... mobile biometrics market is projected to generate more ... during the seven-year forecast period.    ...
(Date:7/9/2015)... July 9, 2015  Unchained Labs just can,t ... acquisition of Avid Nano. Avid Nano designs, develops ... systems.    Also today, Unchained Labs ... easiest to use protein sizing system. The pUNk ... protein,s hydrodynamic size, size distribution, aggregation population and ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... around the world are joining efforts to demonstrate ... symposium on "Maintaining health with nutrient rich diets: ... syndrome, cardiovascular disease (CVD), obesity and sarcopenia." ... of Nutritional Science (IUNS) Congress of Nutrition, taking ...
... for generating part of the skeletal support for the ... Now, Jean-Franois Joanny from the Physico Chemistry Curie Unit ... found that a well-defined layer beneath the cell outer ... generated by motor proteins within the cellular system. These ...
... who are HIV positive don,t know it, yet testing and ... international standards of cost-effectiveness and save millions of lives ... population every five years according to a new study published ... are based on a careful analysis of India,s HIV epidemic ...
Cached Biology News:First international collaboration to showcase latest body of evidence of dairy health benefits 2Cost-effective: Universal HIV testing in India 2Cost-effective: Universal HIV testing in India 3Cost-effective: Universal HIV testing in India 4
(Date:7/29/2015)... -- US-Australian drug discovery company, Novogen Limited (ASX: NRT; ... to progressing its ground-breaking technology platforms to Phase 1 ... the Company delivers the best value for shareholders. ... said the Company currently had an extensive program of ... and academic partnerships and initiatives, and he was working ...
(Date:7/29/2015)... Inc. (NYSE: BIOA ) today announced that ... resigned.  The Company has hired Andrew Ashworth , ... 2014, as full time interim CFO and has launched ... Andy Ashworth began his employment today, to overlap ... was the Company,s CFO from September 2011 to December ...
(Date:7/29/2015)...  AsureQuality and Ubiquitome have agreed to collaborate ... food and primary production sectors. The collaboration will ... the Freedom4. AsureQuality provides quality assurance ... shelf for producers, processors and Competent Authorities around ... control and pest management and surveillance programmes. ...
(Date:7/29/2015)... 29, 2015 Research ... addition of the "Global Biosimilars Market, 2015 ... The Global Biosimilars Market, 2015 - 2025, ... growing biosimilars market. With the blockbuster biologics losing ... costs, biosimilars are being viewed as viable substitutes ...
Breaking Biology Technology:Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3
... Wis. - Alfalight, Inc., announced the release ... in two configurations for delivery in September. , ,The CPM-II ... 200-micron (0.22 NA) output fiber for fiber laser applications. A ... 5/125 micron signal/pump fiber) is also available for fiber amplifier ...
... had a chance to dig into some more music. A constant reminder ... I am hoping that he is the next Jonny Lang who will ... a week of rock 'n roll camp. , ,Can you imagine this: ... This kind of reminded me of the movie "School of Rock" with ...
... company hires an independent computer programmer to write software. All ... important part of its business. All too often as well, ... a written contract, the specifics of ownership of the intellectual ... later (perhaps as a result of the sale of the ...
Cached Biology Technology:Historic lists - The greatest rock bands, rock guitarists of all time 2Historic lists - The greatest rock bands, rock guitarists of all time 3Historic lists - The greatest rock bands, rock guitarists of all time 4Who owns software developed for your company? 2Who owns software developed for your company? 3Who owns software developed for your company? 4
Mouse monoclonal antibody raised against a partial recombinant ZNF167. NCBI Entrez Gene ID = ZNF167...
...
...
... UniPrimer-fluorescein is a hairpin primer labeled ... (fluorescein and non-fluorescent quencher) and a ... UniPrimer is identical to the UniPrimer ... System (S7901) and is provided at ...
Biology Products: