Navigation Links
Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Date:12/3/2007

GLEN OAKS, NY Scientists at the Zucker Hillside Hospital campus of the Feinstein Institute for Medical Research have identified nine genetic markers that can increase a persons risk for schizophrenia. In a study published this week in the Proceedings of the National Academy of Sciences, the research team uncovered original evidence that this disabling brain disease can be inherited in a recessive manner. A recessive trait is one that is inherited from both parents.

If a person inherits identical copies of these markers from each parent, his or her risk for schizophrenia increases substantially, said Todd Lencz, PhD, associate director of research at Zucker Hillside and the lead author of the study. If these results are confirmed, they could open up new avenues for research in schizophrenia and severe mental illness, said Anil Malhotra, MD, director of psychiatric research at Zucker Hillside and senior investigator of the study.

The scientists developed a complex mathematical approach called whole genome homozygosity association (WGHA) that provides a new way of analyzing genetic information. It enables scientists to simultaneously look at genetic information derived from the patients mother and father, and identify pieces of chromosomes that are identical. They tested genetic material from 178 patients and 144 controls.

It has been the prevailing view in psychiatric genetics that there are probably dozens, if not hundreds, of genetic variations that could lead to schizophrenia, but each gene has a small effect. It is the wrong mix of many genes, plus unknown environmental stressors, that trigger the onset of symptoms. One in every 100 people suffer from schizophrenia, a condition marked by episodes of hallucinations, delusions and disordered thinking.

The new findings suggest another scenario, at least for a subset of patients. Dr. Lencz and his colleagues identified nine regions along the chromosomes that might play a large role in triggering the disease when two identical variants are inherited. Four of these regions contain genes that have been previously associated with schizophrenia, providing validation for the technique. The remaining five regions provide an additional set of newly discovered genetic risk factors. Many genes located in these regions are involved with the structure and survival of neurons.

In genetic parlance, several of these markers demonstrated high penetrance, meaning that their effect on disease risk was large. In the study, 81 percent of the schizophrenia patients had at least one of these recessive markers, compared to only 45 percent of the normal control group. Nearly half of the patients had two or more compared to 11 percent of the controls. And while no one in the healthy group had identical chunks of chromosomes in four or more of these risk regions, subjects with more than three demonstrated a 24-fold increased risk of developing schizophrenia. This type of analysis could greatly improve our ability to diagnose schizophrenia and clarify specific subtypes of patients, Dr. Lencz said. The critical next step is confirming these results in independent datasets.

What is most exciting is that the study implicates new genes in schizophrenia, said David Goldman, MD, chief of laboratory of neurogenetics at the National Institute on Alcohol Abuse and Alcoholism. Now, they have to trace down the genes that mediate this vulnerability. Identifying these novel genes will eventually help improve understanding of the disease and lead to the development of more effective treatments, the scientists said.


'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 23, 2017 , ... ... of high quality relocatable and permanent modular buildings, announced the launch of ... and modern office design characteristics to help support on-site teamwork and collaboration. ...
(Date:5/23/2017)... ... May 23, 2017 , ... Firmex today ... makes it easy for organizations to send and gather large files and confidential ... or email file size limitations. , Using the same market-tested infrastructure as ...
(Date:5/23/2017)... ... May 22, 2017 , ... NetDimensions has been ... Aragon Research Globe™ for Corporate Learning, 2017. , Aragon Research defines Leaders as ... and effectively perform against those strategies. NetDimensions’ ranking as a Leader due to ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... as Vice President of Clinical Operations. She brings years of expertise in establishing ... From her professional foundation as a licensed occupational therapist, through a variety of ...
Breaking Biology Technology: