Navigation Links
Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
Date:12/3/2007

GLEN OAKS, NY Scientists at the Zucker Hillside Hospital campus of the Feinstein Institute for Medical Research have identified nine genetic markers that can increase a persons risk for schizophrenia. In a study published this week in the Proceedings of the National Academy of Sciences, the research team uncovered original evidence that this disabling brain disease can be inherited in a recessive manner. A recessive trait is one that is inherited from both parents.

If a person inherits identical copies of these markers from each parent, his or her risk for schizophrenia increases substantially, said Todd Lencz, PhD, associate director of research at Zucker Hillside and the lead author of the study. If these results are confirmed, they could open up new avenues for research in schizophrenia and severe mental illness, said Anil Malhotra, MD, director of psychiatric research at Zucker Hillside and senior investigator of the study.

The scientists developed a complex mathematical approach called whole genome homozygosity association (WGHA) that provides a new way of analyzing genetic information. It enables scientists to simultaneously look at genetic information derived from the patients mother and father, and identify pieces of chromosomes that are identical. They tested genetic material from 178 patients and 144 controls.

It has been the prevailing view in psychiatric genetics that there are probably dozens, if not hundreds, of genetic variations that could lead to schizophrenia, but each gene has a small effect. It is the wrong mix of many genes, plus unknown environmental stressors, that trigger the onset of symptoms. One in every 100 people suffer from schizophrenia, a condition marked by episodes of hallucinations, delusions and disordered thinking.

The new findings suggest another scenario, at least for a subset of patients. Dr. Lencz and his colleagues identified nine regions along the chromosomes that might play a lar
'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... RIVERSIDE, Calif. Thomson Reuters , a leading ... five researchers at the University of California, Riverside in ... brightest minds of our times." , To generate the ... (2002-2012) to identify researchers whose published work has had ... included among some 3,200 individuals who published the greatest ...
(Date:8/22/2014)... remember the after-effects, including pain, swelling or redness. These ... the injury. When tissue in the body is damaged, ... An inflammatory response acts as a protective mechanism to ... after injuries such as wounds and burns. However, the ... which foreign material is introduced, for example when synthetics ...
(Date:8/22/2014)... reductase (DHCR24) is a multifunctional enzyme ... and has neuroprotective and cholesterol-synthesizing activities. ... caused by amyloid β deposition. Dr. ... University in China constructed two recombinant ... DHCR24 expression specifically in neuronal cells. ...
Breaking Biology News(10 mins):5 UC Riverside scientists among world's most influential scientific minds 2Tissue regeneration using anti-inflammatory nanomolecules 2
... supermarket headlines tell us so., Inquiring Texas research minds ... tiny, sometimes obscure pest that can damage plants during ... cotton for about four weeks," said Dr. Megha Parajulee, ... feed on new plant growth, primarily the first small ...
... ago, "ultraconserved elements" were discovered in the genomes of mice, ... in length or longer -- some are over 700 base ... three species. They have been perfectly conserved since the last ... 85 million years ago. These and other highly ...
... cells could take a mix of enzyme ingredients, blend ... elaborate chemical structure such as penicillin. Researchers at UC ... of Pharmacy and Pharmaceutical Sciences and the University of ... to mimic this process outside of a cell. ...
Cached Biology News:Inquiring minds want to know about cotton fleahoppers 2Inquiring minds want to know about cotton fleahoppers 3Ultraconserved elements in the genome: Are they indispensable? 2Ultraconserved elements in the genome: Are they indispensable? 3Ultraconserved elements in the genome: Are they indispensable? 4Researchers develop simple method to create natural drug products 2
(Date:8/21/2014)... 21, 2014 2014 Deep ... is a professional and in-depth research report ... provides basic Seaweed Fertilizer information, including Seaweed ... structure as well as industry overview. This ... domestic market as well as global industry ...
(Date:8/21/2014)... Emmetsburg, IA (PRWEB) August 21, 2014 ... Project LIBERTY Opening , The Court of His Majesty ... King will attend the Grand Opening of POET-DSM Advanced ... on Wednesday, Sept. 3. , The King will take ... formal opening activity, scheduled for 11 a.m.-12:20 p.m. and ...
(Date:8/21/2014)... The College of New Rochelle announced ... the Mid-Hudson Region to be designated as a START-UP ... from qualified “high-technology” businesses that align with the College’s ... have been selected for the START-UP NY program and ... stimulate economic development in New York by growing business ...
(Date:8/21/2014)... Mathematic studies at the Program for Evolutionary Dynamics ... Jeffrey Epstein VI Foundation , have shown that the ... elimination. These aggressive cells are the driver mutations that drive ... of what to look for when examining tumors, comes at ... can be extracted from biopsy, it,s very difficult to know ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2
... , COLLEGEVILLE, Pa., Aug. 11 Wyeth ... it received notice that the action date for the U.S. Food ... License Application (BLA) for Prevnar 13(TM), (Pneumococcal 13-valent ... 2009, to December 30, 2009. In response to an FDA ...
... , , PORTLAND, Ore., Aug. ... announce patent award approval on August 11 to Dimera Incorporated for ... known as Peripheral Vascular Disease (PVD). , , ... (Number 7572780 ) covers the period August 11, 2009 through ...
... ... sugar feedstocks, , ... (Vocus) August 11, 2009 -- BP and Martek Biosciences Corporation (Nasdaq: MATK), today announced ... microbial oils for biofuels applications. The partnership combines a broad technology platform and operational ...
Cached Biology Technology:Wyeth Provides Regulatory Update on Prevnar 13* in the United States 2Wyeth Provides Regulatory Update on Prevnar 13* in the United States 3Wyeth Provides Regulatory Update on Prevnar 13* in the United States 4Wyeth Provides Regulatory Update on Prevnar 13* in the United States 5Wyeth Provides Regulatory Update on Prevnar 13* in the United States 6Peripheral Artery Disease (PAD) Patent Granted to Dimera 2BP and Martek Biosciences Enter Joint Development Agreement to Deliver Advanced Biodiesels 2BP and Martek Biosciences Enter Joint Development Agreement to Deliver Advanced Biodiesels 3BP and Martek Biosciences Enter Joint Development Agreement to Deliver Advanced Biodiesels 4
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
... processes up to 48 lanes, 24 bi-directional, ... can be from either slab gel or ... chemistries. The detection parameters in Explorer have ... consistency. We have built Explorer for ...
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
...
Biology Products: