Navigation Links
Feeding the clock
Date:11/25/2009

LA JOLLA, CAWhen you eat may be just as vital to your health as what you eat, found researchers at the Salk Institute for Biological Studies. Their experiments in mice revealed that the daily waxing and waning of thousands of genes in the liverthe body's metabolic clearinghouseis mostly controlled by food intake and not by the body's circadian clock as conventional wisdom had it.

"If feeding time determines the activity of a large number of genes completely independent of the circadian clock, when you eat and fast each day will have a huge impact on your metabolism," says the study's leader Satchidananda (Satchin) Panda, Ph.D., an assistant professor in the Regulatory Biology Laboratory.

The Salk researchers' findings, which will be published in a forthcoming issue of the Proceedings of the National Academy of Sciences, could explain why shift workers are unusually prone to metabolic syndrome, diabetes, high cholesterol levels and obesity.

"We believe that it is not shift work per se that wreaks havoc with the body's metabolism but changing shifts and weekends, when workers switch back to a regular day-night cycle," says Panda.

In mammals, the circadian timing system is composed of a central circadian clock in the brain and subsidiary oscillators in most peripheral tissues. The master clock in the brain is set by light and determines the overall diurnal or nocturnal preference of an animal, including sleep-wake cycles and feeding behavior. The clocks in peripheral organs are largely insensitive to changes in the light regime. Instead, their phase and amplitude are affected by many factors including feeding time.

The clocks themselves keep time through the fall and rise of gene activity on a roughly 24-hour schedule that anticipates environmental changes and adapts many of the body's physiological function to the appropriate time of day.

"The liver oscillator in particular helps the organism to ada
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Northern brown bears discovered feeding on whitefish runs
2. New Automatic cell feeding station PROcellcare for life cell imaging
3. Dioxins in food chain linked to breastfeeding ills
4. Breastfeeding duration and weaning diet may shape childs body composition
5. Bolivian rainforest study suggests feeding behavior in monkeys and humans have ancient, shared roots
6. Social support during breast-feeding helps humans have more children
7. Fast-food diet cancels out benefits of breastfeeding in preventing asthma
8. Crib-side studies help struggling newborns go home without feeding tubes
9. New infant feeding and obesity research adds insight to ongoing issue
10. Facebook flack regarding breastfeeding mothers
11. Benefits of breastfeeding outweigh risk of infant exposure to environmental chemicals in breastmilk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Feeding the clock
(Date:7/11/2014)... Mineral Research awarded Michael F. Holick, PhD, MD, of ... Louis V. Avioli Award. Holick, a professor of medicine, ... revolutionizing the understanding of vitamin D and its role ... member of the American Society for Bone and Mineral ... basic research. It is named for ASBMR,s first president ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2A new genome editing method brings the possibility of gene therapies closer to reality 2
... (September 25, 2007) Stem cell therapy for cardiac ... media will be the focus of the keynote addresses ... Treatment of Cardiovascular Disease conference. Conducted by Cedars-Sinai Medical ... and 5, the conference is co-sponsored by the California ...
... For several months last spring, the Vanderbilt greenhouse held ... than are known to exist in the wild., This ... by Jennifer Ellis, a doctoral student in the biological ... E. McCauley., The species is called the giant whorled ...
... Cryptochromes, which fulfill the molecular requirements for sensing the ... neurons of migratory birds (Mouritsen et al., PNAS, 2004). ... brain are active when the birds use their magnetic ... and a forebrain region (Cluster N; Mouritsen et al., ...
Cached Biology News:Cardiologists and heart surgeons meet for 'Controversies and Advances' conference 2Cardiologists and heart surgeons meet for 'Controversies and Advances' conference 3Student study bolsters case for adding a rare sunflower to the endangered species list 2
(Date:7/10/2014)... journal PNAS (Proceedings of the National Academy of ... sleep deprivation have a significant effect on our metabolism. ... best time of day to test for diseases such ... effectively. , Researchers from the University of Surrey and ... between sleep deprivation, body clock disruption and metabolism, and ...
(Date:7/10/2014)... our laptops and electric vehicles could store more energy ... help of a sponge-like silicon material. , Researchers ... used in one of the battery,s electrodes, as silicon ... of graphite. A paper describing the material,s performance as ... Nature Communications . , "Silicon has long been sought ...
(Date:7/10/2014)... the University of Illinois at Urbana-Champaign provides new ... of spin and heat at the nanoscale, and ... for data storage and information processing. , ... momentum. In a typical charge current, electrons, spin-angular-momentum ... explained David Cahill, a professor of materials science ...
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
Breaking Biology Technology:Time of day crucial to accurately test for diseases, new research finds 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3University of Illinois study advances limits for ultrafast nano-devices 2A deeper look at interfaces 2
... launched interactive, personalized services for Milwaukee drivers through ... announced Thursday. Traffic.com will provide area commuters with ... roadway traffic conditions including congestion levels, incidents, travel ... news release. , ,Data for the site will ...
... Madison, Wis. - While human stem cells offer potential ... the more immediate benefit from research into such cells will ... an area that for many years has been steeped in ... research since disease works within the context of cells. , ...
... - Healthcare professionals will have the opportunity hear about ... profession at the Wisconsin Dairyland HIMSS Fall Technology Conference ... the Radisson hotel in La Crosse, will be split into ... events such as a golf outing and a riverboat cruise, ...
Cached Biology Technology:Human stem cells called great opportunity for drug discovery 2Human stem cells called great opportunity for drug discovery 3Conference will review healthcare IT 2
... is a major step forward in ... handling system - with one universal ... modules. All five single channel and ... one handle. The lightweight handle is ...
alpha-N-Catenin Antibody Shipping Temperature: HOT Storage Temperature: -20C...
... EC3 Darkroom is designed for imaging of ... EC3 systems offer direct control for users ... settings by hand , A range of ... system for all fluorescent and chemiluminescent applications ...
... is designed for multiple user laboratories for ... TLC applications. The MultiDoc-It is available without ... provides a darkroom environment and protects the ... image capture and enhancement , The ...
Biology Products: