Navigation Links
February 2009 highlights from Biology of Reproduction
Date:1/20/2009

Bliss* blocks sperm. Evidence suggests that human male fertility is impacted by long-term exposure to marijuana. Indeed, endocannabinoids and their receptors are present in the male reproductive tract, further suggesting a functional role in fertility, but there has been no genetic test to clarify mechanisms. Now, in a paper on p. 235 of this issue, Sun et al. characterize the phenotype of mice genetically lacking FAAH, fatty acid amide hydrolase. Male mice homozygous for the Faah knockout have elevated levels of anandamide, an endocannabinoid, in the reproductive system, and their sperm have decreased ability to fertilize due to poor penetration of the egg's zona pellucida. These results point to previously unsuspected pathways regulating sperm function. But perhaps more importantly, they are of great clinical significance: because sperm of chronic marijuana users, as well as sperm in Faah-mutant males are exposed to enhanced cannabinoid/endocannbinoid signaling, clinically beneficial effects of anandamide must be weighed against potentially harmful effects on fertility. (*Note: The term anandamide for the endocannabinoid arachidonoylethanolamide was coined by the discoverer of this compound, Dr. Mechoulam; "ananda" means bliss or ecstasy.)

Xiaofei Sun, Haibin Wang, Masaru Okabe, Kenneth Mackie, Philip J. Kingsley, Lawrence Marnett, Benjamin Cravatt, and Sudhansu K. Dey. Genetic Loss of Faah Compromises Male Fertility in Mice. Biol Reprod 2009; 235-242. Published in BOR-Papers in Press 5 November 2008; DOI: 10.1095/biolreprod.108.072736


Offspring of male geezers: a new wrinkle. Although mammalian males can reproduce until late in life, evidence of hazards to offspring has emerged in human and animal models. Two papers in this issue (pp. 337 and 343) provide clear, well-controlled data of deleterious effects on the offspring of aged male mice mated to females of prime reproductive age. The offspring from the elderly males exhibit abnormalities not only in several behavioral traits, but also in reproductive fitness and longevity. The early death of offspring sired by old mice was heralded by rapid weight loss. Moreover, mating the offspring derived from aged males resulted in the production of pups exhibiting decreased weights at weaning when compared with pups from the offspring of younger males: an apparent transgenerational effect. The defects causing the abnormalities in offspring are unknown and should be the objective of intriguing studies in the future.

Silvia Garca-Palomares, Jos F. Pertusa, Jos Mi arro, Miguel A. Garca-Prez, Carlos Hermenegildo, Francisco Rausell, Antonio Cano, and Juan J. Tarn. Long-Term Effects of Delayed Fatherhood in Mice on Postnatal Development and Behavioral Traits of Offspring. Biol Reprod 2009; 337-342. Published in BOR-Papers in Press 15 October 2008; DOI: 10.1095/biolreprod.108.072066

Silvia Garca-Palomares, Samuel Navarro, Jos F. Pertusa, Carlos Hermenegildo, Miguel A. Garca-Prez, Francisco Rausell, Antonio Cano, and Juan J. Tarn. Delayed Fatherhood in Mice Decreases Reproductive Fitness and Longevity of Offspring. Biol Reprod 2009; 343-349. Published in BOR-Papers in Press 15 October 2008; DOI: 10.1095/biolreprod.108.073395


'/>"/>

Contact: Judith Jansen
ssradmin@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related biology news :

1. January-February GSA Bulletin media highlights
2. Media highlights for February in Biophysical Journal
3. Story tips from the Department of Energys Oak Ridge National Laboratory, February 2008
4. Highlights from the February 2008 Journal of the American Dietetic Association
5. February Geology and GSA Today media highlights
6. Phoenix conference highlights TGens and Scottsdale Healthcares contributions to molecular oncology
7. January GEOLOGY media highlights
8. AGU journal highlights -- Dec. 31, 2008
9. December Geosphere media highlights
10. December 2008 Geology and GSA Today media highlights
11. bioMETRX, Inc. Highlights 3rd Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
(Date:3/14/2016)... Florida , March 14, 2016 ... the growing mobile commerce market, announces the airing of a ... channels starting the week of March 21 st .  The ... CNBC, including its popular Squawk on the Street show. ... focused on the growing mobile commerce market, announces the airing ...
(Date:3/10/2016)... 10, 2016 --> ... report "Identity and Access Management Market by Component (Provisioning, ... Governance), by Organization Size, by Deployment, by Vertical, and ... MarketsandMarkets, The market is estimated to grow from USD ... 2020, at a Compound Annual Growth Rate (CAGR) of ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... ... variety of fracture-specific plating options designed to address fractures of the distal tibia ... solutions. , The Acumed Ankle Plating System 3 is composed of seven plate ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Lady had ... she tore her cruciate ligament in her left knee. Lady’s owner Hannah sought the ... central Florida board-certified veterinary surgeon, to repair her cruciate ligament and help with the ...
(Date:5/24/2016)... ... May 24, 2016 , ... Media Cybernetics, global image ... Cybernetics corporate branding reflects a results-driven revitalization for a company with a renewed ... components include a crisp, refreshed logo and a new web presence. , “I ...
(Date:5/23/2016)... LONDON , May 23, 2016 - ... by 40% - Frontage Implement a Single Platform to ... Compliance and Traceability Within the Bioanalytical lab Frontage Laboratories, ... the United States and China , ... its laboratory facilities. In addition to serving as the global electronic ...
Breaking Biology Technology: