Navigation Links
Fear factor: Missing brain enzyme leads to abnormal levels of fear in mice, reveals new research
Date:7/15/2013

MAO A/B, which regulates neurotransmitters known as monoamines, including serotonin, norepinephrine and dopamine.

Comparing mice without MAO A/B with their wild-type littermates, the researchers found significant differences in how the mice without MAO A/B processed fear and other types of learning. Mice without MAO A/B and wild mice were put in a new, neutral environment and given a mild electric shock. All mice showed learned fear the next time they were tested in the same environment, with the MAO A/B knockout mice displaying a greater degree of fear.

But while wild mice continued to explore other new environments freely after the trauma, mice without the MAO A/B enzymes generalized their phobia to other contexts their fear spilled over onto places where they should have no reason to be afraid.

"The neural substrates processing fear in the brain is very different in these mice," Singh said. "Enhanced learning in the wrong context is a disorder and is exemplified by these mice. Their brain is not letting them forget. In a survival issue, you need to be able to forget things."

The mice without MAO A and MAO B also learned eye-blink conditioning much more quickly than wild mice, which has also been noted in autistic patients but not in mice missing only one of these enzymes.

Importantly, the mice without MAO A/B did not display any differences in learning for spatial skills and object recognition, the researchers found, "but in their ability to learn an emotional event, the [MAO A/B knockout mice] are very different than wild types," Singh said.

He continued: "When both enzymes are missing, it significantly increases the levels of neurotransmitters, which causes developmental changes, which leads to differential expression of receptors that are very important for synaptic plasticity a measure of learning and to behavior that is quite similar to what we see along the autism spectrum."


'/>"/>

Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover a missing link in signals contributing to neurodegeneration
2. Strange phallus-shaped creature provides crucial missing link
3. Monell scientists help identify a missing link in taste perception
4. Missing polar weather systems could impact climate predictions
5. Microbial missing link discovered after man impales hand on tree branch
6. Missing link discovered in the defence mechanism of the tuberculosis pathogen
7. UCLA researchers discover missing link between stem cells and immune system
8. What we know and dont know about Earths missing biodiversity
9. Researchers discover first gene linked to missing spleen in newborns
10. Artifact suppression and analysis of brain activities with EEG signals
11. Low levels of toxic proteins linked to brain diseases, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... is pleased to announce the promotion of Yaniv ... of Digital Forensics. In Schiff,s new role as Director, ... team of digital forensics examiners and provide leadership within ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 Schiff ...
(Date:11/6/2014)... paper from a team of Florida State University biologists ... could adapt to and survive environmental swings such as ... latest issue of the journal The Plant Cell ... DNA and proteins) is organized in a cell and ... are turned on and others are turned off. , ...
(Date:11/5/2014)... RENO – Kelly Redmond has dedicated his career ... knowledge to a general audience. , As deputy ... Climate Center at Nevada,s Desert Research Institute, Redmond ... the management, application and dissemination of climate data ... Annual Fall Meeting in San Francisco on December ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Maize analysis yields whole new world of genetic science 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2
... Three-day-old broccoli sprouts, a widely available human food, suppressed ... a report in Cancer Prevention Research , a journal ... pylori infections are one of the most common bacterial ... The cancer protective effects of sulforaphane, a phytochemical ...
... As the U.S. Southwest grew warmer from 18,700 to ... the Mojave Desert, robbing packrats of their favorite food. Now, ... genes that let the rodents eat toxic creosote bushes that ... out," says biology Professor Denise Dearing, senior author of the ...
... for Kids" event on April 18 at Pembroke ... Va., April 2 Turner Network Sales (TNS), ... Inc. (TBS, Inc.), and truTV, are partnering with Cox Communications ... "Digital Fingerprinting for Kids" event , a service designed to ...
Cached Biology News:Poison: It's what's for dinner 2Poison: It's what's for dinner 3Poison: It's what's for dinner 4Poison: It's what's for dinner 5truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children 2truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children 3
(Date:11/26/2014)... MADRID , Nov. 26, 2014 ... presented results from a survey of European physicians ... Meeting on Innovation and Biological Therapies" at the ... The event, hosted by EuropaBio and the Spanish ... Ministry of Health, physicians from Spanish oncology and ...
(Date:11/26/2014)... November 26, 2014 The ETC ... award-winning technology innovation centers, announced today that applications ... on December 1st. “Do you have a big ... I want to know about it. AccelerateBaltimore helps ... to product in just 13 weeks.” Interested ...
(Date:11/26/2014)... November 25, 2014 Whitehouse Laboratories ... joined the Morris County (New Jersey) Chamber of ... a leading business organization in the North Jersey ... further engage some key clients in the pharmaceutical ... the geographic area. Membership enables Whitehouse Laboratories a ...
(Date:11/26/2014)... November 25, 2014 Silicon Valley Electronic ... with RPM Alliance , provider of clinical research ... With the latest addition to its CRO Partnership Program, ... EDC system to India. , “We have found ... and customizable EDC platform which is both user friendly ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2
... president and CEO Michael J. Collins delivered the commencement address ... Department, which was held on May 18, 2012. Collins received ... been a member of the Advisory Board for the Chemistry ... (Logo: http://photos.prnewswire.com/prnh/20090622/CL35336LOGO-b ) "I am ...
... one in four adults suffering from a diagnosable ... high case loads, the value of independent living ... effective mental health services. ILCs are generally thought ... physical disabilities, but across the country, directors and ...
... 24, 2012  Novocure™, a commercial stage private oncology company, ... of excellence will join the seven existing clinical centers ... patients with recurrent GBM. These fifteen clinical centers are ... GBM is both the deadliest and most ...
Cached Biology Technology:CEM President and CEO Delivers Commencement Address at the 2012 University of Texas at Austin Chemistry and Biochemistry Department Graduation 2Peers Underscored As An Effective Counseling Tool 2Novocure™ Certifies Eight Additional Clinical Centers of Excellence to Treat Most Common Brain Tumor with Tumor Treating Fields (TTFields) Therapy 2Novocure™ Certifies Eight Additional Clinical Centers of Excellence to Treat Most Common Brain Tumor with Tumor Treating Fields (TTFields) Therapy 3Novocure™ Certifies Eight Additional Clinical Centers of Excellence to Treat Most Common Brain Tumor with Tumor Treating Fields (TTFields) Therapy 4
... bovine, porcine, rat) ... antagonist. This carboxy-terminal VIP fragment ... more potent than any previously ... Storage: Desiccate ...
Protein 3D structure prediction, via threading. Easy to use....
L1 Protein of Human Papilloma Virus Purified Anti-Viral-transformed cells clone CAMVIR-1, Isotype Mouse IgG 2a , 0.1 mg Consult technical datasheet for details....
ANTI 5-HYDROXYTRYPTOPHAN CONJ....
Biology Products: