Navigation Links
Fear factor: Missing brain enzyme leads to abnormal levels of fear in mice, reveals new research
Date:7/15/2013

A little bit of learned fear is a good thing, keeping us from making risky, stupid decisions or falling over and over again into the same trap. But new research from neuroscientists and molecular biologists at USC shows that a missing brain protein may be the culprit in cases of severe over-worry, where the fear perseveres even when there's nothing of which to be afraid.

In a study appearing the week of July 15 in the Proceedings of the National Academy of Sciences, the researchers examined mice without the enzymes monoamine oxidase A and B (MAO A/B), which sit next to each other in our genetic code as well as on that of mice. Prior research has found an association between deficiencies of these enzymes in humans and developmental disabilities along the autism spectrum such as clinical perseverance the inability to change or modulate actions along with social context.

"These mice may serve as an interesting model to develop interventions to these neuropsychiatric disorders," said senior author Jean C. Shih, USC University Professor and Boyd & Elsie Welin Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy and the Keck School of Medicine of USC. "The severity of the changes in the MAO A/B knockout mice compared to MAO A knockout mice supports the idea that the severity of autistic-like features may be correlated to the amounts of monoamine levels, particularly at early developmental stages."

Shih is a world leader in understanding the neurobiological and biochemical mechanisms behind such behaviors as aggression and anxiety. In this latest study, Shih and her co-investigators including lead author Chanpreet Singh, who was a doctoral student at USC at the time of the research and is now at CalTech, and Richard Thompson, USC University Professor Emeritus and Keck Professor of Psychology and Biological Sciences at the USC Dornsife College of Letters, Arts and Sciences expand their past research on
'/>"/>

Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover a missing link in signals contributing to neurodegeneration
2. Strange phallus-shaped creature provides crucial missing link
3. Monell scientists help identify a missing link in taste perception
4. Missing polar weather systems could impact climate predictions
5. Microbial missing link discovered after man impales hand on tree branch
6. Missing link discovered in the defence mechanism of the tuberculosis pathogen
7. UCLA researchers discover missing link between stem cells and immune system
8. What we know and dont know about Earths missing biodiversity
9. Researchers discover first gene linked to missing spleen in newborns
10. Artifact suppression and analysis of brain activities with EEG signals
11. Low levels of toxic proteins linked to brain diseases, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... -- According to a new market research ... (Pen & Paper Based, Hosted, Biometrics), Service, Application (Clinical ... Vertical and Region - Global Forecast to 2020", published ... from USD 2.4 Billion in 2015 to USD 7.5 ... (CAGR) of 25.6% from 2015 to 2020. ...
(Date:8/26/2015)... 2015 The report "Multi-Factor Authentication (MFA) ... Application (Travel & Immigration, Government, Banking, Defense, Commercial Security, ... 2020", published by MarketsandMarkets, Multi-Factor Authentication Market is expected ... a CAGR of 17.7% between 2015 and 2020. ... igures spread through 169 P ages ...
(Date:8/25/2015)... BELLEVUE, Wash. , Aug. 25, 2015 ... systems, announced today it will unveil its "Guardian S" ... at the National Tactical Officers Association Conference on August ... Guardian S is the first-ever commercially available energetically autonomous ... research and in-field trials and is protected by more ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3
... old wives, tale: Sleeping too much does not make you fat. ... body mass index (BMI) in twins, which found that sleeping more ... body weight. The study looked at 1,088 pairs of ... was associated with both increased BMI and greater genetic influences on ...
... have identified a new gene that could help the development ... from Durham University, UK, and Osaka University, Japan, looking at ... the gene, which makes a protein called PDILT, enables sperm ... The team found that when the gene was ,switched ...
... In a rapid communication just published in the Canadian ... the Gulf Fisheries Centre and Robert Mohn, emeritus scientist, at ... delay in recovery of Atlantic cod on the eastern Scotian ... or other governing factors and not the effect of forage ...
Cached Biology News:Gene involved in sperm-to-egg binding is key to fertility in mammals 2
(Date:8/30/2015)... England , August 31, 2015 /PRNewswire/ ... 51-jährige Wartezeit   einer Frau   für chirurgische   ... Alter von 7-90   werden für eine ... Programm soll 1200 Frauen behandeln und die Anzahl ausgebildeter ... Astellas gab heute bekannt, dass  Action ...
(Date:8/28/2015)... , Aug. 28, 2015 ... addition of the "Global & USA BioSimilar Market ... The highly awaited US Biosimilar market will be ... filigrastim biologic, Zarxio. How will the global market react? ... reveals that biosimilars could save the US economy up ...
(Date:8/28/2015)... India , August 28, 2015 ... by Product (Media, Sera, Cryogenic Storage Systems, Thawing Equipment, ... (Therapeutic, Regenerative Medicine, Clinical Trials), End User - Global ... Market is expected to reach USD 3,731.03 Million by ... a CAGR of 11.65% between 2015 and 2020. ...
(Date:8/28/2015)... ... 2015 , ... Proove Biosciences , a commercial and ... Intervention Society’ s 23rd Annual Scientific Meeting (ASM). The ASM event took ... on evidence-based research and clinical application, the event gathered industry thought leaders to ...
Breaking Biology Technology:Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 2Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 3Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 4Über 550 Frauen, deren Leben durch "Action on Fistula" transformiert wurde 5Global & USA BioSimilar Market Analysis Report 2015-2021 2Global & USA BioSimilar Market Analysis Report 2015-2021 3Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4
... ... Safety Solutions Continues to Accelerate., , ... (PRWEB) June 22, 2010 -- iCardiac Technologies, Inc. , a ... top 20 pharmaceutical companies have recently selected iCardiac as a preferred vendor. iCardiac ...
... 21 A global research team led by scientists ... new study in the Proceedings of the National Academy of ... genome. Lead author, Ewen Kirkness , Ph.D., JCVI, directed ... of the genome was then conducted by a large international ...
... 21 Dyadic International, Inc. (Pink Sheets: DYAI), ... addresses the needs of the multi-billion dollar biofuels market ... biomass into ethanol and other forms of alternative energy, ... firm, The Abraham Group, to provide strategic advice and ...
Cached Biology Technology:Three Top 20 Pharmaceutical Companies Select iCardiac as Preferred Vendor 2Multinational Research Team Led by J. Craig Venter Institute's Ewen Kirkness Sequence Body Louse Genome 2Multinational Research Team Led by J. Craig Venter Institute's Ewen Kirkness Sequence Body Louse Genome 3Dyadic International Engages The Abraham Group as Strategic Advisor 2Dyadic International Engages The Abraham Group as Strategic Advisor 3Dyadic International Engages The Abraham Group as Strategic Advisor 4