Navigation Links
Faulty proteins may prove significant in identifying new treatments for ovarian cancer
Date:1/13/2012

PORTLAND, Ore. -- A constellation of defective proteins suspected in causing a malfunction in the body's ability to repair its own DNA could be the link scientists need to prove a new class of drugs will be effective in treating a broad range of ovarian cancer patients, an Oregon Health & Science University Knight Cancer Institute study found.

These research results, published this week in PLoS ONE, have prompted additional exploration into whether the patient population included in clinical trials for drugs that target the enzyme poly ADP ribose polymerase (PARP) should be expanded. Several forms of cancer are more dependent on PARP for their growth than regular cells, which means that targeting these enzymes when they go haywire is a potentially effective way to treat ovarian cancer. Currently PARP inhibitors are being tested with patients who have two types of malfunctioning proteins, BRCA1 or BRCA2. But, the OHSU Knight Cancer Institute study of additional proteins, beyond BRCA proteins, suggests that they too are playing a role in driving ovarian cancer.

Tapping into the potential of PARP inhibitors could change the dynamics of ovarian cancer treatment. There has not been a substantial increase in treatment options for ovarian cancer in the past two decades, said Tanja Pejovic, M.D., Ph.D., gynecologic oncologist at the OHSU Knight Cancer Institute. Pejovic, who led the study of these additional defective proteins, added that the results provide evidence that further research into the role of multiple proteins is warranted.

Only about 10 to 15 percent of women with ovarian cancer have BRCA 1 or BRCA 2 mutations.

Pejovic's study of 186 patients with nonhereditary cancer found that 41 percent who had an early recurrence of the disease also had abnormal levels of the other proteins tracked. In contrast, only 19.5 percent of patients who hadn't yet had a recurrence of the disease in three years had abnormal levels of these proteins.

"If we are able to identify the proteins that differentiate these patients at risk for early recurrence, this would open up a new direction in ovarian cancer treatment," Pejovic said.
'/>"/>

Contact: Elisa Williams
willieli@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Related biology news :

1. Faulty molecular switch can cause infertility or miscarriage
2. Faulty gene linked to disorders of sexual development
3. Faulty clean-up process may be key event in Huntingtons disease
4. Penn scientists pioneer new method for watching proteins fold
5. Lets do the twist: Spiral proteins are efficient gene delivery agents
6. Control by the matrix: RUB researchers decipher the role of proteins in the cell environment
7. Cellular processing of proteins found in Congolese child birthing tea now revealed
8. Targeted antibacterial proteins may offer antibiotic alternative
9. New technique enables study of challenging proteins
10. So many proteins, so much promise
11. Exercise before and during early pregnancy increases two beneficial proteins for mothers-to-be
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... , June 22, 2016   StockNewsNow.com , The ... Interview with Dr. Nader Pourhassan , President & ... focused on the clinical development and potential commercialization of ... HIV infection, according to the company,s website (see here: ... Tuesday, June 7 th , 2016, at the LD ...
(Date:6/22/2016)... , June 22, 2016   ViaCyte, Inc. ... pluripotent stem cell-derived islet replacement therapy for the treatment ... at ISSCR 2016 Annual Meeting.  ISSCR 2016, the Global ... 25th at Moscone West in San Francisco.  ... the presentations are as follows:Event: , Focus Session: Tools ...
(Date:6/22/2016)... ... 2016 , ... The Immigrant Journey Awards , an ... North Texas and the nation, recently held its annual luncheon program. Awards ... and economic vitality of North Texas. Proceeds from the event are used to ...
(Date:6/22/2016)... and ALBANY, N.Y. , ... (Teewinot) and Albany Molecular Research, Inc. (NASDAQ: ... licensed Teewinot,s technology to produce and sell the ... The CBCA analytical standard is manufactured using Teewinot,s ... expression of cannabinoid biosynthetic genes in microorganisms for ...
Breaking Biology Technology: