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Fatty acid metabolite shows promise against cancer in mice
Date:4/2/2013

wound healing, while the EDPs block the growth and metastasis of solid tumors.

"Our results designate EDPs and EETs as unique mediators of an angiogenic switch to regulate tumorigenesis," Ferrara said. "They also implicate a novel mechanistic linkage between omega-3 and omega-6 fatty acids and cancers."

UC Davis scientists determined that EDP starves tumors by inhibiting vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2)-induced angiogenesis in mice. In laboratory cultures, EDP also suppresses the endothelial cell migration needed for new blood vessels.

Thus, EDP-based angiogenesis inhibitors offer an advantage over angiogenesis inhibitors that target the VEGF-VEGFR2 pathway. The drugs that target the VEGF-VEFGFR2 pathway increase patients' risk for high blood pressure.

Because EDPs widen the blood vessels, a medication based on the UC Davis researchers' discovery should not increase the patient's risk for high blood pressure.

Harvard researchers Mark Kieran and Dipak Panigrahy conducted the metastasis studies. The in vivo imaging work that allowed the scientists to monitor tumors in living mice was done in Ferrara's UC Davis laboratory.


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Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

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