Navigation Links
Fatty acid metabolite shows promise against cancer in mice
Date:4/2/2013

wound healing, while the EDPs block the growth and metastasis of solid tumors.

"Our results designate EDPs and EETs as unique mediators of an angiogenic switch to regulate tumorigenesis," Ferrara said. "They also implicate a novel mechanistic linkage between omega-3 and omega-6 fatty acids and cancers."

UC Davis scientists determined that EDP starves tumors by inhibiting vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2)-induced angiogenesis in mice. In laboratory cultures, EDP also suppresses the endothelial cell migration needed for new blood vessels.

Thus, EDP-based angiogenesis inhibitors offer an advantage over angiogenesis inhibitors that target the VEGF-VEGFR2 pathway. The drugs that target the VEGF-VEFGFR2 pathway increase patients' risk for high blood pressure.

Because EDPs widen the blood vessels, a medication based on the UC Davis researchers' discovery should not increase the patient's risk for high blood pressure.

Harvard researchers Mark Kieran and Dipak Panigrahy conducted the metastasis studies. The in vivo imaging work that allowed the scientists to monitor tumors in living mice was done in Ferrara's UC Davis laboratory.


'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cellular renewal process may underlie benefits of omega fatty acids
2. Could ending your fatty food habit cause withdrawal symptoms and depression?
3. UCSB anthropologists finds high levels of omega-3 fatty acids in breast milk of Amerindian women
4. Cellular secrets of plant fatty acid production understood
5. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
6. Researchers unravel genetic mechanism of fatty liver disease in obese children
7. Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
8. Appetite genes are key to better diets for poultry, study shows
9. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
10. UF study shows spiders, not birds, may drive evolution of some butterflies
11. Study shows how one insect got its wings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Our eyes not ... with a continuous stream of information about our own movements. ... a car the world glides by us and leaves ... our brain calculates self-motion from this "optic flow". This way, ... during our own movements. Together with biologists from the University ...
(Date:4/17/2014)... to produce hydrogen sulfide in order to properly multiply ... from the Center for Craniofacial Molecular Biology at the ... Songtao Shi, principal investigator on the project, said the ... the flow of calcium ions. The essential ions activate ... or the creation of new bone tissue, and keeps ...
(Date:4/17/2014)... Singh Thursday as a "Champion of Change" for ... in the residential, commercial and industrial sectors. , ... and Computer Engineering and director of Clemson,s Center ... leading the charge across the country to create ... driving policy changes at the local level to ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4White House honors Clemson professor as 'Champion of Change' for solar deployment 2
... international team of scientists led by King,s College London has ... (short-sightedness). Myopia is a major cause of ... cure. These findings, published today in the journal Nature ... lead to finding better treatments or ways of preventing the ...
... (NGS) technology has revolutionized biomedical research, making complete ... for a wide variety of research applications. Bioinformatics ... critical bottleneck for many researchers and organizations wishing ... DNA Sequencing Informatics provides a thorough introduction ...
... throughout Vienna it was impossible not to notice that the ... around the courtyards of the inner city nor woke tired ... no longer there. Thankfully, they gradually reappeared and a ... levels. But the sudden crash in numbers was alarming ...
Cached Biology News:New genes for short-sightedness identified 2Forensic pathology: tracing the origin of the Usutu Virus 2
(Date:1/14/2014)... WASHINGTON , Jan. 14, 2014  3D Communications, a leading provider ... scientific, regulatory, business, and media events in the United ... its former associate Virginia Cox , JD, is returning to ... Virginia Cox re-joins 3D after more than two years ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Canada (PRWEB) January 14, 2014 In ... its motives and methods in product development and promotion ... the industry. This mistrust, fueled by concerns about the ... fed by reports of spectacular fines to the world’s ...
(Date:1/14/2014)... ®, provider of RapidResponse ®, a cloud-based supply chain ... S&OP ) service, is proud to be a gold sponsor ... at the Hilton San Diego Bayfront, January 30 – 31, ... , Director of Supply Chain at Amgen, as she presents ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... New sol-gel inks developed by researchers at the University ... three-dimensional structures of metal oxides with nanoscale features. , ... nanoscale opens a new avenue to functional devices. Potential ... The researchers describe the new inks in a paper ...
... Calif., Oct. 11 CompareNetworks,Media Group, the leading ... industries, today announced the launch of Acuity Medical,Education, ... CompareNetworks. With the arrival of two key new ... Liza Frenzik as Special,Projects Director, the CompareNetworks team ...
... Fisher,Scientific Inc. (NYSE: TMO ), the world ... construct an $11 million, state-of-the-art BioCenter,for the manufacture ... the site of its existing bioprocess production business ... a response to the increasing demand for,disposable bioprocessing ...
Cached Biology Technology:Sol-gel inks produce complex shapes with nanoscale features 2CompareNetworks Media Group Delivers CME/CE Through Acuity Medical Education 2Thermo Fisher Scientific to Expand Manufacturing Operation for Single-Use Bioprocessing Containers 2Thermo Fisher Scientific to Expand Manufacturing Operation for Single-Use Bioprocessing Containers 3Thermo Fisher Scientific to Expand Manufacturing Operation for Single-Use Bioprocessing Containers 4
iEMS Thermal Microplate Holder...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... RNase H- Reverse Transcriptase (RT) is an ... RT. It is a DNA polymerase that ... RNA DNA or an RNA:DNA hybrid. This ... of point mutations rather than a deletion ...
Biology Products: