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Fate in fly sensory organ precursor cells could explain human immune disorder
Date:6/21/2009

have discovered here has a relationship to what is happening in the patients with Wiskott-Aldrich syndrome. The patients with Wiskott-Aldrich syndrome have mutations in a gene called WASp. WASp is an activator of the Arp2/3 complex. In our work we found that WASp is also required for the trafficking of Delta to the top of the actin structure," said Bellen.

Notch signaling is required for proper development, differentiation and activation of a class of immune cells called the T-cells. T-cell function is compromised in patients with Wiskott-Aldrich syndrome. Since the gene WASp is mutated in the patients with Wiskott-Aldrich syndrome, the work done by Bellen and his colleagues suggest that defects in the presentation of Delta could explain the loss and dysfunction of T-cells in patients with Wiskott-Aldrich syndrome.


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Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2 3

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