Navigation Links
Fat stem cells safe for breast reconstruction when cancer is dormant, says Pitt team
Date:9/16/2010

PITTSBURGH, Sept. 15 Fat-derived stem cells can be safely used to aid reconstruction of breast tissue after mastectomy as long as there is no evidence of active cancer, according to researchers at the University of Pittsburgh School of Medicine. Their findings are available in Tissue Engineering Part A.

Plastic surgeons have long moved fat from one part of the body into the breasts for reconstruction, but with some complications and a varying success rate, explained senior author Vera S. Donnenberg, Ph.D., assistant professor of surgery, Pitt School of Medicine. More recently, they have considered adding stem cells derived from adipose, or fat, tissue (ADSC) or the bone marrow to the transferred fat with the aim of supporting graft integration by enhancing new blood vessel formation.

"But it has not been clear whether these stem cells are safe for breast cancer patients because they could send growth signals that promote tumor reactivation or provide new blood vessels for the tumor," Dr. Donnenberg said. "Our research suggests that this risk is real if the patient still has active tumor cells, but is safe when the cells are inactive or resting."

For the study, the researchers collected adipose tissue that would have been discarded during "tummy tuck" procedures performed by study co-author J. Peter Rubin, M.D., associate professor of surgery, Pitt School of Medicine, whose team has several federally funded projects underway to develop fat grafting and stem cell therapies for reconstruction of a variety of tissues.

The researchers isolated ADSC from normal fat and mixed them with human breast cancer cells obtained directly from patients. After two weeks in culture they found that ADSC greatly encouraged the growth of tumor cells. In a followup experiment, the researchers injected small numbers of highly purified active or resting tumor cells under the skin of mice either with ADSC or with previously irradiated tumor ce
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. How cells manage their genes focus of $1.4 million NSF grant to Florida State
2. First US trial of bone-marrow stem cells for heart attack patients proves safe
3. A smart use for wisdom teeth: Making stem cells
4. Brain cells determine obesity -- not lack of willpower: Study
5. These cells will self-destruct in 5...4...
6. With HMGB1s help, cells dine in
7. Researchers identify how bone-marrow stem cells hold their breath in low-oxygen environments
8. Co-conspirator cells could hold key to melanoma prediction, prevention
9. Microfluidic device allows collection, analysis of hard-to-handle immune cells
10. Fat serves as cells built-in pH sensor: UBC research
11. Macrophages: The defense cells that help throughout the body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... new study from UC San Francisco is the first ... accumulate overtime and accelerate cellular aging, these negative effects ... and sleeping well. , "The study participants who ... shortening than the ones who didn,t maintain healthy lifestyles, ... lead author Eli Puterman, PhD, assistant professor in the ...
(Date:7/28/2014)... the South Pole in 1911, but new research shows ... , Using data from 16 ice cores collected from ... South Pole, a group led by Joe McConnell of ... the most accurate and precise reconstruction to date of ... described in an article published today in the online ...
(Date:7/28/2014)... TEMPE, Ariz. - Reactions among minerals and organic compounds ... deep carbon cycle, they provide energy for the deep ... life. However, very little is known about how minerals ... Arizona State University have demonstrated how a common mineral ... negating the need for toxic solvents or expensive ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3
... University] Researchers from Brown University and the University of ... in breast cancers are related to environmental risk factors and ... disease. The study is published in today,s edition of ... of tumors had a direct association with diet, alcohol, and ...
... have high accumulations of the material beta-amyloid, which appear ... plaques are believed to be the underlying cause of ... in memory that characterize Alzheimer,s disease. The main aim ... formation of beta-amyloid. Since beta-amyloid is cleaved from the ...
... This release is available in German . ... and Marine Research in the Helmholtz Association for the first ... mission at about 79 North. The four-metre-long, torpedo shaped underwater ... pack ice. The vehicle was subsequently recovered by helicopter. ...
Cached Biology News:Study finds diet and alcohol alter epigenetics of breast cancer 2New approach to Alzheimer's therapy 2Highlight of the Polarstern expedition 2
(Date:7/29/2014)... HILLS, Calif. , July 29, 2014 /PRNewswire/ ... specializing in personalized medicine, treatment of infectious diseases ... strategies of prognosis and prevention of pathologies like ... of August 1, 2014, ImmunoClin Corporation will complete ... Washington, D.C. , a key ...
(Date:7/29/2014)... Philadelphia, PA (PRWEB) July 29, 2014 Philadelphia’s ... to help businesses get their start. The Innovation Center ... and the University City Science Center to help ... its doors on Monday, July 28. , ... corner of 34th and Market Streets, is the new home ...
(Date:7/29/2014)... South Carolina (PRWEB) July 29, 2014 DisasterTalk ... teams of people where cell phone masts or other transmitters ... up to 100 feet away without the need for any ... target longer ranges. , The new app has launched as ... US homes are at very high risk of being affected ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 G-CON Manufacturing ... modular cleanrooms, today announced a new leadership appointment designed ... United States and abroad. , Maik Jornitz, Chief ... the company’s President charged with leading the pioneering company ... we enter this stage of development and look forward ...
Breaking Biology Technology:ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2G-CON Manufacturing, Inc. Announces Maik Jornitz as President 2
... receive funding for technology development projects from the ... Grant program. , ,The TAG program provides grants ... companies to offset the cost of professional services. ... Automated Notification Systems, Inc. , Eau Claire; Micrablate, ...
... the balkanization of information technology in healthcare will take ... Digital Healthcare Conference 2006 . And vendors aren't necessarily ... customers. , ,Providers are facing that common IT problem: ... of vendors and systems with challenges agreeing to standards, ...
... a gathering of health professionals attending the eHealth Summit ... first state to have a fully integrated electronic medical ... barriers. , ,Speaking before a group of healthcare executives, ... state's eHealth Initiative, Doyle said those barriers include organizational ...
Cached Biology Technology:Being proactive with vendors helps healthcare improve IT 2Doyle asks health professionals to overcome barriers 2Doyle asks health professionals to overcome barriers 3
Request Info...
Prepared in distilled water....
... white. The extinction coefficient , E(1%) at ... phosphate-buffered saline, pH 7.4, containing ... 50% glycerol. Avidin (from egg white) is conjugated ... molecular sieving and is completely ...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
Biology Products: