Navigation Links
Fat serves as cells' built-in pH sensor: UBC research
Date:8/26/2010

A specific type of fat present in cell membranes also serves as a cellular pH sensor, a team of University of British Columbia researchers has discovered.

pH is a measure of acidity or basicity. Cells need to maintain pH in order to perform their normal cellular functions. However, the mechanisms by which cells monitor pH were unknown.

"Scientists have known that specific proteins can detect changes in pH under certain circumstances," says Chris Loewen, an assistant professor in the Department of Cellular and Physiological Sciences in the UBC Faculty of Medicine and a member of the UBC Life Sciences Institute. "But we found that a specific phospholipid, or fat, called phosphatidic acid, which is present in all cells, is actually responsible for detecting pH."

The findings are published today in the journal Science.

"Using brewer's yeast as a model, we found that, when deprived of nutrients, the resulting decrease in cellular pH affected the chemical state of phosphatidic acid. This in turn altered gene expression and cellular metabolism," says Dr. Loewen, who is also a member of the Brain Research Centre at UBC and Vancouver Coastal Health Research Institute.

The new findings have important implications for understanding human metabolism and disease because lipid structure and function are very similar amongst all organisms. Further work is needed to explore the implications of this discovery for other areas, such as tumour progression because both phosphatidic acid and pH play important roles in this process and brain research because brain cells dynamically change their cellular pH, implying they, too, use a pH sensor.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Most panda habitat is outside nature reserves according to joint MSU-Chinese research
2. IEEE-USA pleased that Supreme Courts ruling preserves software patents
3. Scientists find community involvement, not only enforcement, drives success of marine reserves
4. Inflammation on switch also serves as off switch
5. Studies show marine reserves can be an effective tool for managing fisheries
6. El Paso County serves as a model for obesity prevention, according to UT School of Public Health study
7. Sugar on bacteria surface serves as base for a web of resistance
8. In troubled economic times, BioSquare 2009 successfully serves as business and innovation starter
9. SUNY Downstate researchers find that memory storage molecule preserves complex memories
10. Macrophages: The defense cells that help throughout the body
11. MIT researchers develop a better way to grow stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... April 25, 2017 , ... ... Metrology Partners.     , Covalent’s Analytical Services unit provides high-quality data to ... measured within 24 hours of receipt. There are no price premiums, and customers ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... ... from thermal denaturation in a cellular milieu; however, the broad application of this ... of simple platforms with sensitive quantitative readouts. Cell-based thermal stabilization assays are valuable ...
(Date:4/21/2017)... DENVER, COLORADO (PRWEB) , ... April 21, 2017 ... ... Manufacturing. Awards recognized outstanding manufactures in 10 categories with over 30 nominees and ... Women in Manufacturing presented the new award and the event was hosted by ...
(Date:4/21/2017)... ... April 21, 2017 , ... The University of ... round funding to three startups through the UConn Innovation Fund. The $1.5 million ... startups affiliated with UConn. , The UConn Innovation Fund provides investments of up ...
Breaking Biology Technology: