Navigation Links
Fat-regenerating 'stem cells' found in mice
Date:10/10/2008

Researchers have identified stem cells with the capacity to build fat, according to a report in the October 17th issue of the journal Cell, a Cell Press publication. Although they have yet to show that the cells can renew themselves, transplants of the progenitor cells isolated from the fat tissue of normal mice can restore normal fat tissue in animals that are otherwise lacking it.

The findings may yield insight into the causes of obesity, a condition characterized by an increase in both the size and number of fat cells.

"In obesity, there is an increase in fat cell number," said Matthew Rodeheffer of The Rockefeller University. "The question is: what are the events that lead to that increase? You need to know how fat cell number is normally regulated to know what goes wrong in obesity. Identifying fat cell precursors is a first step toward understanding this process"

Earlier studies identified cells with the capacity to differentiate into fat in lab dishes. However, those cells proved unable or extremely limited in their ability to form fat in living animals.

In the new study, the research team led by Jeffrey Friedman first removed fat tissue from mice and treated the tissue with an enzyme that broke it down into individual cells. Separating the mature fat cells from the rest is a simple proposition, Rodeheffer said, because the lipid-loaded cells float.

They then sorted the remaining cells based on the expression of proteins found at their surfaces, isolating those cells bearing proteins that are known to identify other types of stem cells. Two of the cell populations they isolated could produce fat in lab dishes, they found.

Just one of these two populations had the capacity to re-grow a normal fat pad in mice, they report. The researchers made that discovery by injecting the progenitor cells into the residual fat tissue of mice with a condition known as lipodystrophy. Those animals are unable to produce fat no
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly created cancer stem cells could aid breast cancer research
2. Bursts of waves drive immune system soldiers toward invaders
3. AIDS interferes with stem cells in the brain
4. When is a stem cell not really a stem cell?
5. Human derived stem cells can repair rat hearts damaged by heart attack
6. Scientists identify embryonic stem cells by appearance alone
7. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
8. Obesity and the central nervous system -- the state of the art
9. How the plant immune system can drive the formation of new species
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. Upgraded IMG 2.3 Data Management System released by DOE JGI to eager user community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
(Date:4/22/2014)... for Experimental Biology (FASEB) has released updated factsheets ... from the National Institutes of Health (NIH) benefits each ... is pleased to make these factsheets available to help ... their state," said FASEB President, Margaret K. Offermann, MD, ... research funding, investing $29.2 billion in FY 2013 ...
(Date:4/22/2014)... of breeding bird surveys sent in by citizen scientists ... years, wildlife researchers report that most of the 40 ... higher elevation in response to climate change, but did ... previous studies of potential climate change impacts on wildlife ... have likely underestimated the effects of environmental warming, say ...
Breaking Biology News(10 mins):Wildlife response to climate change is likely underestimated, experts warn 2
... especially in intensive production. Piglets commonly become susceptible to ... to losses of 10% or more. The antibiotics used ... have now fallen out of use, mainly due to ... A radical solution has been found by using a ...
... cushy haploid environs to take up residence in a ... but Indiana University Bloomington scientists report in this week's ... plants. , "Plants that reproduce clonally or are ... mitochondrion to the nucleus," said graduate student Yaniv Brandvain, ...
... that help shape our understanding of how tool use ... chimpanzees, at least under some conditions, are capable of ... The work, reported by Jill Pruetz of Iowa State ... will appear online in the journal Current Biology on ...
Cached Biology News:A healthier start to a pig's life 2Mitochondrial genes move to the nucleus -- but it's not for the sex 2Chimpanzees found to use tools to hunt mammalian prey 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... 2014 Freeslate, Inc ., the ... that Lupin Limited, one of India’s top five pharmaceutical ... PharmD System for high throughput solid form screening. ... on a wide range of quality, affordable generic and ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... offers revolutionary orthotic prescription ... ... Technologies will,debut the new Xtremityscan System and give away a free ... at the,Disneyland Hotel., Xtremityscan is a digital shape acquisition system ...
... ... Laboratories, NEW YORK, ... that its Owlstone Nanotech Inc.,("Owlstone") subsidiary has received a purchase order ... IEE, an,innovative developer of specialized sensing systems with a global,leadership position ...
... Genaera,Corporation (Nasdaq: GENR ) today announced that Jack ... present at the BIO,Business Forum. The presentation will provide an ... San Diego Convention Center in San,Diego on Tuesday, June 17, ... will also join a panel of experts to discuss new ...
Cached Biology Technology:PAL Health Technologies Debuts Xtremityscan System at Western Podiatric Medical Congress 2Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 2Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 3Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 4Genaera Corporation to Present at BIO Business Forum 2Genaera Corporation to Present at BIO Business Forum 3
... Vybrant Apoptosis Assay Kit #4 ... that occur in the permeability of cell ... both YO-PRO-1 and propidium iodide nucleic acid ... plasma membranes of apoptotic cells and labels ...
Request Info...
Services include subcloning into an expression vector. Tagged protein will be expressed in small scale for testing yield and solubility and then in 1L culture for large scale affinity purification. E...
Request Info...
Biology Products: