Navigation Links
Fat cells in abdomen fuel spread of ovarian cancer
Date:10/30/2011

lism to thrive on lipids acquired from fat cells. Ovarian cancer can rapidly convert the entire omentum, a soft fat pad, into a solid mass of cancer cells.

"This mechanism may not be limited to ovarian cancer cells," the authors note. Fat metabolism may also contribute to cancer development in other environments where fat cells are abundant, such as breast cancer.

A protein known as fatty acid binding protein (FABP4), a fat carrier, may be crucial to this process and could be a target for treatment.

When the researchers compared primary ovarian cancer tissue with ovarian cancer tissue which had spread to the omentum, they found that tumor cells next to omental fat cells produced high levels of FABP4. Cancer cells distant from the fat cells did not produce FABP4.

When they inhibited FABP4, the transfer of nutrients from fat cells to cancer cells was drastically reduced. Inhibition of FABP4 also reduced tumor growth and the ability of tumors to generate new blood vessels.

"Therefore," the authors wrote, "FABP4 emerges as an excellent target in the treatment of intra-abdominally disseminating tumors, which preferentially metastasize to adipose tissue such as ovarian, gastric, and colon cancers."


'/>"/>
Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Evidence for spinal membrane as a source of stem cells may advance spinal cord treatment
2. Lung stem cells offer therapeutic clues
3. Students coax yeast cells to add vitamins to bread
4. Space debris, more efficient LEDs, and thinner, cheaper solar cells
5. Dormant malaria parsites in red blood cells may contribute to treatment failure
6. New discoveries on the state of hemoglobin in living red blood cells
7. Cells are crawling all over our bodies, but how?
8. Simple nerve cells regulate swimming depth of marine plankton
9. Regenerating eyes using cells from hair: Stem Cells awards research into stem cell deficiency
10. Water channels in the body help cells remain in balance
11. Light can detect pre-cancerous colon cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat cells in abdomen fuel spread of ovarian cancer
(Date:5/18/2013)... today at Digestive Disease Week (DDW) explores new discoveries ... of coffee on autoimmune disease and palliative care for ... been associated with reduced risk of fibrosis, a new ... java each month also correlate with lower risk for ... Clinic, Rochester, MN, linked coffee consumption with reduced risk ...
(Date:5/17/2013)... 18, 2013) The AGA Research Foundation announced a ... relationship between the gut microbiota, one of today,s most ... , The AGA Research Awards Panel selected Andrew ... General Hospital and Harvard Medical School, Boston, as the ... Chan will receive $25,000 of funding, commencing in July ...
(Date:5/17/2013)... the science and technology of the region and ... inaugural Atlanta Science Festival, March 22-29, 2014. With ... K-12 schools and universities, the festival will host ... adults at venues across the city. Learn more ... Atlanta Science Festival is a collaboration of scientific, ...
Breaking Biology News(10 mins):Coffee consumption associated with reduced risk of autoimmune liver disease 2New gut microbiome research to explore red meat -- colorectal cancer pathway 2First Atlanta Science Festival set for 2014 2
... ever found in Canada is revealing how plants struggled to ... -- buried by a landslide and exquisitely preserved 2 to ... today,s Arctic will respond to global warming. They also ... America as Arctic ice continues to melt. As the wood ...
... of Oceanography at UC San Diego have provided the ... light produced by a little-known sea snail. Dimitri ... now at the Australian Museum in Sydney) studied a ... found in tight clusters or groups at rocky shorelines. ...
... They say it,s the little things that count, and that ... which are small enough to allow ions or molecules of ... objects. Artificial fluidic nanochannels that mimic the capabilities of transmembrane ... However, it has been difficult to make individual artificial channels ...
Cached Biology News:Ancient forest emerges mummified from the Arctic 2Ancient forest emerges mummified from the Arctic 3Scripps scientists see the light in bizarre bioluminescent snail 2Tiny channels carry big information 2Tiny channels carry big information 3
(Date:5/20/2013)... 20, 2013 Oven Industries Inc. announces ... capabilities. The 5R6-900 benchtop controller has many outstanding user-friendly ... be plugged into the wall as a self-contained temperature ... distinctive detail makes the device unique, as well as ... temperature controller can also be used universally, which allows ...
(Date:5/20/2013)... ANGELES , May 20, 2013 Today, ... San Francisco , James McGough ... Clinical Psychiatry at the Semel Institute for Neuroscience and ... of Medicine at the University of California Los ... both Child and Adolescent Psychopharmacology and ADHD at UCLA, ...
(Date:5/20/2013)... -- Dr. Gerald Zon , noted scientist ... a new blog in conjunction with TriLink BioTechnologies. The ... on what,s trending in the field of nucleic acids. ... of research presented at conferences and meetings, reviews of ... (PhD Princeton University 1971) developed automated synthesis of DNA ...
(Date:5/20/2013)... With bed bugs' presence come problems in various terms. ... to be eliminated, one must make sure that the bed ... so to help bed bug sufferers get that done, it ... bugs without using harmful pesticides. In it, the company ... Bug Bully. , According to My Cleaning Products, contrary to ...
Breaking Biology Technology:New Laboratory Temperature Controller by Oven Industries 2Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 2Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 3Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 4Positive Results Reported for Phase I Clinical Trial at UCLA for the Treatment of ADHD in Children Using External Trigeminal Nerve Stimulation (eTNS) 5Dr. Gerald 'Jerry' Zon Launches New Blog for TriLink BioTechnologies 2New Non Pesticide Discovery on How to Get Rid of Bed Bugs Tipped by My Cleaning Products 2
... ExonHit Therapeutics, a,drug and diagnostic discovery company, ... disease test. The company expects to have,this test ... in its GLP (Good,Laboratory Practices) compliant laboratories to ... initial ExonHit test aims to identify patients suffering ...
... WALTHAM, Mass., Nov. 8 Inverness Medical,Innovations, Inc. (Amex: ... to sell,subject to market and other conditions, 7,000,000 shares ... statement in an,underwritten public offering. Certain selling stockholders of ... shares of common stock in the,offering. The Company expects ...
... Navy, The Citadel Are Among The Organizations Advocating Use ... Cleansers With CHG for Ongoing Prevention and Protection, ... Staphylococcus aureus) deadlier than AIDS, and the media continue,to ... most extreme cases,student deaths due to this drug-resistant staph ...
Cached Biology Technology:ExonHit Completes a Prototype to Detect Alzheimer's Disease From Blood 2ExonHit Completes a Prototype to Detect Alzheimer's Disease From Blood 3ExonHit Completes a Prototype to Detect Alzheimer's Disease From Blood 4Inverness Medical Innovations Announces Proposed Public Offering of Common Stock 2Inverness Medical Innovations Announces Proposed Public Offering of Common Stock 3Soap and Water May not be Enough to Fight MRSA Superbug 2Soap and Water May not be Enough to Fight MRSA Superbug 3
Bovine Brain Microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
... adapter allows the Thermo-Fast® ... AB-1000) PCR plates to ... ABI PRISM® 3700 capillary ... for information on the ...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
Spectrolyse (pL) PAI kit is a two-stage indirect enzymatic assay for the quantitative determination of Plasminogen Activator Inhibitor (PAI-1) activity in plasma. Sample Type: plasma...
Biology Products: