Navigation Links
Fat cells in abdomen fuel spread of ovarian cancer
Date:10/30/2011

A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011.

Ovarian cancer, the fifth leading cause of cancer deaths in women, tends to spread within the abdominal cavity as opposed to distant organs. In 80 percent of women, by the time ovarian cancer is diagnosed, it has spread to the pad of fat cells, called the omentum. Often, cancer growth in the omentum exceeds the growth of the original ovarian cancer.

"This fatty tissue, which is extraordinarily rich in energy-dense lipids, acts as a launching pad and energy source for the likely lethal spread of ovarian cancer," said study author Ernst Lengyel, MD, PhD, professor of obstetrics and gynecology at the University of Chicago. "The cells that make up the omentum contain the biological equivalent of jet fuel. They feed the cancer cells, enabling them to multiply rapidly. Gaining a better understanding of this process could help us learn how to disrupt it."

The researchers performed a series of experiments to identify the role of these fat cells as major mediators of ovarian cancer metastasis. The first step was to understand the biological signals that attract ovarian cancer cells to the omentum and use it for rapid growth.

The spread of ovarian cancer cells to the omentum can happen quickly. Ovarian cancer cells injected into the abdomen of healthy mice find their way to the omentum within 20 minutes. The researchers found that protein signals emitted by the omentum can attract the tumor cells. Inhibitors which disturbed these signals reduced this attraction by at least 50 percent.

Once ovarian cancer cells reach the omentum, they quickly develop the tools to devour the sustenance provided by this fatty tissue, reprogramming their metabo
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Evidence for spinal membrane as a source of stem cells may advance spinal cord treatment
2. Lung stem cells offer therapeutic clues
3. Students coax yeast cells to add vitamins to bread
4. Space debris, more efficient LEDs, and thinner, cheaper solar cells
5. Dormant malaria parsites in red blood cells may contribute to treatment failure
6. New discoveries on the state of hemoglobin in living red blood cells
7. Cells are crawling all over our bodies, but how?
8. Simple nerve cells regulate swimming depth of marine plankton
9. Regenerating eyes using cells from hair: Stem Cells awards research into stem cell deficiency
10. Water channels in the body help cells remain in balance
11. Light can detect pre-cancerous colon cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fat cells in abdomen fuel spread of ovarian cancer
(Date:1/22/2015)... ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform its shareholders ... Washington,s Department of Licensing, in the United States, awarded ... for driver,s licenses and identification cards to its subsidiary, Valid ... start in January 2015, with enrollment and card production starting ...
(Date:1/22/2015)... man-made form of insulin delivered by nasal spray may ... with mild cognitive impairment and Alzheimer,s disease dementia, according ... Forest Baptist Medical Center. The study,s subjects ... (MCI) or mild to moderate Alzheimer,s dementia (AD). Those ...
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and ... the addition of the "Global Wearable Technologies ... Growth, Share, Overview, Trends and Forecast 2014-2020" ... Wearable Technologies are smart devices that can be ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... Central,s open access journal Journal of Neuroinflammation ... develop Alzheimer,s disease. To date it has ... in Alzheimer,s disease (AD), especially because trials of NSAIDs ... Alzheimer`s Disease Anti-inflammatory Prevention Trial) trial was stopped early, ...
... director of the Centre for Sports Engineering at Sheffield Hallam ... sprint will be one event not to miss this summer. ... uses very simple physics to compare the relative improvement of ... The model shows that the performance-improvement index in the ...
... "next-gen" technology in genome sequencing has gotten a major boost. ... Harbor Laboratory (CSHL) and collaborators today published results of experiments ... recently introduced but whose use has so far been limited ... Assistant Professor Michael Schatz and Adam Phillippy and Sergey Koren ...
Cached Biology News:Physics confirms sprinters are performing better than ever before 2An error-eliminating fix overcomes big problem in '3rd-gen' genome sequencing 2An error-eliminating fix overcomes big problem in '3rd-gen' genome sequencing 3
(Date:12/24/2014)... GMO corn cases filed across the United States, ... of being consolidated in a Kansas federal court for pretrial ... 162 Corn Litigation, MDL No. 2591 in the U.S. District ... Syngenta GMO corn multidistrict litigation (MDL) has been handed over ...
(Date:12/24/2014)... 2014 SoundConnect’s 2015 ... cutting edge communication technology, provide continued education and ... webinar series demonstrates online communication features and benefits; ... conferencing’s most innovative and powerful tools. , According ...
(Date:12/24/2014)... According to Ross Selinger, President of ... Global, the national office market continues to be strong, driven ... evidenced by the third quarter’s surprising 3.9% GDP, unemployment decreasing ... costs have held inflation down and the Fed is keeping ...
(Date:12/24/2014)... 23, 2014 Nashville Fertility Center announced that ... the American Society for Reproductive Medicine (ASRM), a leading professional ... In his new role as treasurer, Dr. Hill also ... a voice in furthering the mission of ASRM. , ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... with a background in city and state government is ... to attract federal grant money for start-up bioscience and ... Hamilton Consulting Group has added Henry Sanders, ... new government relations venture, hamilton.gsp, which was created in ...
... Wis. - The notion of improving business processes with ... believes the relatively slow pace of adoption means that reluctant ... need for a tutorial can hardly be attributed to a ... summary article, "What is Web 2.0? " bloggers like ...
... what I want any old time. Lyrics from I'm ... hearing this old Rolling Stones standard from the Sixties as ... financial services targeted at Boomers with bloated bank balances (regretably ... aimed at helping people achieve their retirement dreams, it also ...
Cached Biology Technology:Businesses are slow to adopt Web 2.0 concepts 2Businesses are slow to adopt Web 2.0 concepts 3Businesses are slow to adopt Web 2.0 concepts 4Can a talent market work inside organizations? 2Can a talent market work inside organizations? 3Can a talent market work inside organizations? 4Can a talent market work inside organizations? 5Can a talent market work inside organizations? 6
... of Japan, also named Sendai virus) Envelope ... of molecules by means of membrane fusion. ... Protein, Oligo, cDNA, Antibodies, Vector, and Biomolecule ... EX has a high fusing capability in ...
... Dithiothreitol DTT ... INERT GAS. Purity: ≥99% ... metals: Absorbance: (100 ... Soluble in EtOH or H ...
... Dithiothreitol DTT White solid.. PACKAGED ... to thiols, so reaction is "driven" to completion. ... contain waxy surfactant found in many other preparations. ... Purity: ≥97% by titration. Contaminants: ...
... highest precision, more user-friendliness and absolute reliability ... the definition of the Mastercycler ep system. ... research has been developing dynamically. The same ... Systems. To keep pace with these ...
Biology Products: