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Fat and obesity gene also affects hip fracture
Date:9/24/2013

n with hip fracture, with some gene variants doubling the risk of fracture. Interestingly, this effect was independent of both the bone density and BMI of the women we studied."

"We also found that the FTO gene expresses in bone cells, and may have something to do with bone turnover, or remodelling, although its exact mechanisms are unclear."

"It's important to emphasise that, while promising, our finding is a first step. It will need to be replicated in other studies, and its mechanisms clearly understood before it is useful in drug development."

"At Garvan, we developed a Fracture Risk Calculator several years ago, http://www.fractureriskcalculator.com, using data from the Dubbo study. The calculator, which is fairly accurate and easy to use, is very popular with patients and doctors."

"In the future, I would anticipate that genetic risk factors including this finding would be programmed into the calculator, making it an even more finely tuned predictive tool."


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Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research
Source:Eurekalert

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