Navigation Links
Fat and obesity gene also affects hip fracture
Date:9/24/2013

Australian researchers have demonstrated a strong association between the FTO (fat and obesity) gene and hip fracture in women. While the gene is already well known to affect diabetes and obesity, this is the first study to show that its high-risk variant can increase the risk of hip fracture by as much as 82%.

The study, undertaken by Dr Bich Tran and Professor Tuan Nguyen from Sydney's Garvan Institute of Medical Research, examined six gene variants (single nucleotide polymorphisms, or SNPs) of the FTO gene, taken from the DNA of 943 women in the Dubbo Osteoporosis Epidemiology Study (DOES). The women were all over 60, and their bone health was followed between 1989 and 2007. During that period, 102 women had hip fractures.

On average, the risk of fracture is about 11%. The study showed that if a woman has a low-risk genotype, or gene variant, the risk of fracture is 10%. If she has a high-risk genotype, it is 16%.

Now published online in Clinical Endocrinology, the authors believe that the findings have the potential to improve prediction of hip fracture. Known risk factors, also to be taken into account, include advancing age, falls, history of fracture, low bone mineral density, low body mass index (BMI) and genetic make-up.

"We found that for a woman of the same age and same clinical risk factors, those with the high-risk genotype have an increased risk of hip fracture of 82% - a strong effect in genetic terms," said Professor Tuan Nguyen.

"A genome-wide association study published in 2007 suggested that genetic variants in the FTO gene were associated with variation in BMI. This led us to hypothesise that they might also be associated with variation in hip fracture risk, because BMI is a strong predictor of fracture."

"The present study tested our hypothesis by examining the association between common variants in the FTO gene and hip fracture."

"Our results showed a strong associatio
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Education protects women from the obesity associated with urban living
2. Rich or poor in gut bacteria brings new vision for obesity treatment
3. Vigorous physical activity linked to lower incidence of obesity in young African-American women
4. Obesity and mortality association differs between individuals with and without diabetes
5. New IOM report lays out plan to determine effectiveness of obesity prevention efforts
6. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
7. The new frontier: Creating and marketing food products that prevent disease and obesity
8. Obese dads pass on predisposition to obesity and metabolic disorders to their kids
9. New data support community-wide approach to addressing child obesity
10. CNIO researchers discover a new gene involved in obesity
11. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... that could positively impact the global battle ... thanks to researchers in Penn State,s College ... made from the seaweed-derived food ingredient carrageenan ... provides a woman-initiated, drug-delivery vehicle that can ... infections during unprotected heterosexual intercourse, the researchers ...
(Date:8/28/2014)... for measuring and imaging how quickly blood flows in ... how drug abuse affects the brain, which may aid ... to better treatment options for recovering drug addicts. The ... Stony Brook University in New York, USA and the ... The Optical Society,s (OSA) open-access journal Biomedical ...
(Date:8/28/2014)... German . Cars, ... help of sophisticated assembly lines. Mobile assembly carriers, on to ... these assembly lines. In the case of a car body, ... in a precise spatial and chronological sequence, resulting in a ... creation of such an assembly line at molecular level has ...
Breaking Biology News(10 mins):Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3Nanoscale assembly line 2Nanoscale assembly line 3
... years, researchers have identified thousands of cell protein ... that occur within cells of various organisms ... information will be critical to understanding the basic ... these processes contribute to cancer. Unfortunately, the ...
... Scientists have discovered a new way for bacteria ... finding that raises the unsettling possibility that bacterial swapping ... common than previously imagined. , In a laboratory experiment, ... Staphylococcus aureus, a notorious bacterium that causes toxic shock ...
... Journal of the American Dietetic Association features research studies ... why sack lunches may not always meet the nutritional needs ... influences diets of young adults. Packing a Lunch ... Approximately 13 million children in the United States eat three ...
Cached Biology News:Studies offer guide as protein interaction mapping comes of age 2Studies offer guide as protein interaction mapping comes of age 3Studies offer guide as protein interaction mapping comes of age 4NYU scientists discover dangerous new method for bacterial toxin transfer 2NYU scientists discover dangerous new method for bacterial toxin transfer 3NYU scientists discover dangerous new method for bacterial toxin transfer 4News from the January 2009 Journal of the American Dietetic Association 2
(Date:8/28/2014)... Spin-charge converters are important devices in spintronics, an ... charge of electrons but also on their spin ... transformation of electric into magnetic signals and vice ... Sinova from the Institute of Physics at Johannes ... the UK, Prague, and Japan, has for the ...
(Date:8/28/2014)... 28, 2014 The ability for organizations ... that will allow individuals to perform at the highest ... for employers looking to compete in this post–recession era. ... this trend, as the sector increasingly focuses on the ... which will have real results on the organization's development ...
(Date:8/28/2014)... Aug. 28, 2014   SunTrust Robinson Humphrey ... veterans to its equity research team in biotechnology ... expansion in equity research demonstrates our commitment to ... to enhance their investment decision making," said ... "We continue to make significant investments in differentiated ...
(Date:8/28/2014)... 28, 2014  Armetheon, Inc. ( www.armetheon.com ), ... to late-stage cardiovascular drug candidates, today announced that ... round of financing. The Series A round was ... with participation from investors that included Atheneos Capital ... Larry Hsu , the founder of Impax ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3
... CARMEL, Israel, March 19 InSightec Ltd. reported,today that it ... its existing investors. , Elbit Imaging ... on March,18, 2009. Additional US$7.5M would be invested no later ... , The investment will take the ...
... Company estimates sales of pixantrone, if approved, could potentially ... Philips, President of Cell Therapeutics, Inc. (CTI) (NASDAQ and ... the 8th Annual WBBA Invest Northwest Conference on Wednesday, ... CTI,s pixantrone program for treatment of aggressive relapsed non-Hodgkin,s ...
... Team will sail to Baltic, Black and Mediterranean ... funded by local San Diego supporters Beyster Family ... and othersSAN DIEGO, March 18, The J. ... of a new Sorcerer II Expedition--the J. Robert ...
Cached Biology Technology:InSightec Ltd. Announces US$15 Million Investment Round 2InSightec Ltd. Announces US$15 Million Investment Round 3Cell Therapeutics Presents Corporate Highlights at Invest Northwest Conference 2Cell Therapeutics Presents Corporate Highlights at Invest Northwest Conference 3Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 2Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 3Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 4Venter Institute Launches the J. Robert Beyster and Life Technologies 2009-2010 Research Voyage of the Sorcerer II Expedition 5
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
... Kit contains a green fluorescent-labeled inhibitor, FAM-VAD-FMK, ... valylalanylaspartic acid (VAD) fluoromethyl ketone (FMK), a ... added to a population of cells, the ... covalently binds to a reactive cysteine residue ...
Lyophilized solid. Suitable for evaluating functional activity of human complement components and for other research requiring a high level of hemolytic activity. ...
... VersArray ChipWriter Pro system, 220-240 V, uses ... proteins, oligonucleotides, carbohydrates, lipids, and other biomolecules ... applications. This system can generate high-density arrays ... slide or greater than 57,000 spots per ...
Biology Products: