Navigation Links
Fat and obesity gene also affects hip fracture
Date:9/24/2013

Australian researchers have demonstrated a strong association between the FTO (fat and obesity) gene and hip fracture in women. While the gene is already well known to affect diabetes and obesity, this is the first study to show that its high-risk variant can increase the risk of hip fracture by as much as 82%.

The study, undertaken by Dr Bich Tran and Professor Tuan Nguyen from Sydney's Garvan Institute of Medical Research, examined six gene variants (single nucleotide polymorphisms, or SNPs) of the FTO gene, taken from the DNA of 943 women in the Dubbo Osteoporosis Epidemiology Study (DOES). The women were all over 60, and their bone health was followed between 1989 and 2007. During that period, 102 women had hip fractures.

On average, the risk of fracture is about 11%. The study showed that if a woman has a low-risk genotype, or gene variant, the risk of fracture is 10%. If she has a high-risk genotype, it is 16%.

Now published online in Clinical Endocrinology, the authors believe that the findings have the potential to improve prediction of hip fracture. Known risk factors, also to be taken into account, include advancing age, falls, history of fracture, low bone mineral density, low body mass index (BMI) and genetic make-up.

"We found that for a woman of the same age and same clinical risk factors, those with the high-risk genotype have an increased risk of hip fracture of 82% - a strong effect in genetic terms," said Professor Tuan Nguyen.

"A genome-wide association study published in 2007 suggested that genetic variants in the FTO gene were associated with variation in BMI. This led us to hypothesise that they might also be associated with variation in hip fracture risk, because BMI is a strong predictor of fracture."

"The present study tested our hypothesis by examining the association between common variants in the FTO gene and hip fracture."

"Our results showed a strong associatio
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Education protects women from the obesity associated with urban living
2. Rich or poor in gut bacteria brings new vision for obesity treatment
3. Vigorous physical activity linked to lower incidence of obesity in young African-American women
4. Obesity and mortality association differs between individuals with and without diabetes
5. New IOM report lays out plan to determine effectiveness of obesity prevention efforts
6. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
7. The new frontier: Creating and marketing food products that prevent disease and obesity
8. Obese dads pass on predisposition to obesity and metabolic disorders to their kids
9. New data support community-wide approach to addressing child obesity
10. CNIO researchers discover a new gene involved in obesity
11. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... 44th Rosenstiel Award for Distinguished Work in Biomedical Science ... mechanisms of genomic instability and its implications for the ... alumnus to win the Rosenstiel Award; the first, Rod ... is the Charles A. Janeway Professor of Pediatrics and ... investigator at the Howard Hughes Medical Institute at Boston ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
(Date:10/14/2014)... questions is how to produce enough food to feed ... and Agriculture Organization of the United Nations predicts that ... years to feed a growing global population, and plants ... food production. Plants—grains, cereals, fruits, vegetables, and more—feed ... research must tap into our knowledge of how plants ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... Northern Arizona University and the National Center for Ecological ... circuit theory to predict gene flow across landscapes. Their ... the best spots for wildlife corridors, which are crucial ... similarities between circuit theory and ecological connectivity, said Brad ...
... and Post-It Notes Three things that started out as obscure ... will the next idea to stick with modern society look ... a humble lizard, according to a University of Calgary biologist ... to virtually any surface, including glass., Unlike most creatures, geckos ...
... University of the Basque Country (UPV/EHU), an in vitro culture ... reproduce the gene regulation that is expressed in these cancer ... patients. This in vitro culture model provides a simple tool ... factors regulating this expression, as well as a simple form ...
Cached Biology News:Model connects circuit theory to wildlife corridors 2Sticky questions tackled in gecko research 2It is important to demonstrate the influence of the microenvironment in the process of metastasis 2It is important to demonstrate the influence of the microenvironment in the process of metastasis 3
(Date:10/20/2014)... The report “Pharmacy Automation Systems ... and Labeling Systems, Table-top Counters) by End-user (Inpatient ... & Trends to 2019” analyzes and studies the ... America, Europe, Asia-Pacific, and the Rest of the ... 30 figures spread through 300 pages and in-depth ...
(Date:10/20/2014)... PARK, Calif. , Oct. 20, 2014 /PRNewswire/ ... today that the Company has signed a Notice ... of Regenerative Medicine (CIRM), effective October 1, 2014.  ... Clinical Development payments and the release of additional ... million CIRM grant award for clinical development of ...
(Date:10/20/2014)... 20, 2014  GenVec, Inc. (NASDAQ: GNVC ) ... Ph.D., from its board of directors effective on October 24, ... and served as its chairman from June 2006 to November ... and Corporate Governance and Audit Committees of the board.  ... decade of dedicated service to GenVec, and its stockholders," said ...
(Date:10/20/2014)... Earle Martin , Chief Executive ... Ellen Teplitzky, an experienced attorney specializing in business ... has joined the firm as Director of Legal ... NDA Partners provides legal services, including research, ... top law firms and their clients in cases ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... Syngenta today announced that it has acquired Georgia-based ... protection technology to the company,s portfolio. Circle One Global ... a toxin that can develop in crops such as corn ... , "The acquisition of this technology adds an important ...
... ... Biotechnology Laboratory, and support US and European power supplies. , ... Williamstown, NJ (PRWEB) June 11, 2009 -- ... box. The CS230000 and CS230001 both are new Biotechnology kits from A-WIT Technologies. Choose ...
... ... financial services offerings to further meet the needs of emerging businesses. ... on Demand - NSS partners with their clients acting as an outsourced ... Solutions team equips its clients with multiple game plans; a blue print ...
Cached Biology Technology:Syngenta Acquires Innovative Bio-Control Technology to Improve Usable Crop Yields 2Syngenta Acquires Innovative Bio-Control Technology to Improve Usable Crop Yields 3A-WIT Technologies Releases World's First Low Cost C Stamp(TM) Based Biotechnology Laboratory in a Box 2Next Stage Solutions Announces Three New Financial Services For Emerging Business 2Next Stage Solutions Announces Three New Financial Services For Emerging Business 3
Sheep polyclonal to Quinolone ( Abpromise for all tested applications). Antigen: Norfloxacin(N)conjugated to BSA...
...
...
... the 9, 10, 12, and 13 positions. It ... for the quantification of 9(S)-HODE by GC- or ... of linoleic acid in both plants and animals. ... an esterified component of membrane phospholipids and in ...
Biology Products: