Navigation Links
Fat and obesity gene also affects hip fracture
Date:9/24/2013

Australian researchers have demonstrated a strong association between the FTO (fat and obesity) gene and hip fracture in women. While the gene is already well known to affect diabetes and obesity, this is the first study to show that its high-risk variant can increase the risk of hip fracture by as much as 82%.

The study, undertaken by Dr Bich Tran and Professor Tuan Nguyen from Sydney's Garvan Institute of Medical Research, examined six gene variants (single nucleotide polymorphisms, or SNPs) of the FTO gene, taken from the DNA of 943 women in the Dubbo Osteoporosis Epidemiology Study (DOES). The women were all over 60, and their bone health was followed between 1989 and 2007. During that period, 102 women had hip fractures.

On average, the risk of fracture is about 11%. The study showed that if a woman has a low-risk genotype, or gene variant, the risk of fracture is 10%. If she has a high-risk genotype, it is 16%.

Now published online in Clinical Endocrinology, the authors believe that the findings have the potential to improve prediction of hip fracture. Known risk factors, also to be taken into account, include advancing age, falls, history of fracture, low bone mineral density, low body mass index (BMI) and genetic make-up.

"We found that for a woman of the same age and same clinical risk factors, those with the high-risk genotype have an increased risk of hip fracture of 82% - a strong effect in genetic terms," said Professor Tuan Nguyen.

"A genome-wide association study published in 2007 suggested that genetic variants in the FTO gene were associated with variation in BMI. This led us to hypothesise that they might also be associated with variation in hip fracture risk, because BMI is a strong predictor of fracture."

"The present study tested our hypothesis by examining the association between common variants in the FTO gene and hip fracture."

"Our results showed a strong associatio
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-434-071-326
Garvan Institute of Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Education protects women from the obesity associated with urban living
2. Rich or poor in gut bacteria brings new vision for obesity treatment
3. Vigorous physical activity linked to lower incidence of obesity in young African-American women
4. Obesity and mortality association differs between individuals with and without diabetes
5. New IOM report lays out plan to determine effectiveness of obesity prevention efforts
6. Offspring of mothers stressed during pregnancy with a passive stress coping style more prone to obesity
7. The new frontier: Creating and marketing food products that prevent disease and obesity
8. Obese dads pass on predisposition to obesity and metabolic disorders to their kids
9. New data support community-wide approach to addressing child obesity
10. CNIO researchers discover a new gene involved in obesity
11. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)...  BellBrook Labs, a leader in high throughput screening ... a TR-FRET (time resolved Forster resonance energy transfer) ... high throughput screening assay for glycosyltransferases and other ... sensitive detection of hundreds of human and microbial ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... including technology and tech stocks, releases video from the CES ... and security consultant Apollo Robbins . Apollo ... the Wocket™ biometric smart wallet, a product of NXT-ID, Inc. ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... of the "Global Wearable Technologies Market and ... Overview, Trends and Forecast 2014-2020" report to ... are smart devices that can be worn on ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... School of Medicine have found evidence that a hormone ... functions of spatial learning and memory development, and further ... stomach. , Published in the February 19 online issue ... institutes, the study showed that the hormone ghrelin, produced ...
... cartilage offers the first hope of replacing the ... The technique, developed at Rice University's Musculoskeletal Bioengineering ... the journal Tissue Engineering. , "This has significant ... for the first time, about the potential treatment ...
... led by a University of Minnesota researcher has found a ... kinds and sizes and that may also offer a key ... be known precisely in order to construct valid models of ... occur in both plants and animals through the process of ...
Cached Biology News:Learning and memory stimulated by gut hormone 2Rice bioengineers pioneer techniques for knee repair 2Of mice, men, trees and the global carbon cycle 2Of mice, men, trees and the global carbon cycle 3
(Date:12/24/2014)... 2014 SoundConnect’s 2015 ... cutting edge communication technology, provide continued education and ... webinar series demonstrates online communication features and benefits; ... conferencing’s most innovative and powerful tools. , According ...
(Date:12/24/2014)... York (PRWEB) December 23, 2014 According to ... Long Island Affiliate of ITRA Global, the national office market ... steady recovery. This is evidenced by the third quarter’s ... stock market. Low energy costs have held inflation down ...
(Date:12/24/2014)... December 23, 2014 Nashville Fertility Center announced ... for the American Society for Reproductive Medicine (ASRM), a leading ... medicine. In his new role as treasurer, Dr. Hill ... have a voice in furthering the mission of ASRM. ...
(Date:12/24/2014)... Pipette.com announces their Holiday in the ... #HolidayInTheLab pictures for a chance to win pipette-themed gifts for ... think of a holiday gift for their beloved lab mates, ... holiday presents. The #HolidayInTheLab Contest encourages Pipette.com Twitter followers ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... project between the University of Wisconsin-Madison and ... has shown that thousands of sleeping computers can unravel ... , a program first developed at Technion for identifying ... affected families, has since grown to operate on 200 ...
... Information Exchange has been awarded an eHealth initiative ... calendar year 2006. , ,The funds will allow ... to develop its governance structure and administrative staff. To ... through sharp increases in emergency room traffic, the contract ...
... - Metavante Corp ., the banking and ... ., is in the final stages of acquiring ... payment processing software. , ,VICOR is being pursued, in ... solutions to its client financial institutions so they can ...
Cached Biology Technology:UW links with Israeli school to locate genes 2UW links with Israeli school to locate genes 3WHIE receives state eHealth Initiative contract 2
...
Auto/Zyme Reagent...
HistoScan HRP Kit Universal Goat Kit...
Interact with both DNA and RNA; fluorescence green (Em=525 nm) bound to DNA; and fluorescence red (Em=~650 nm) bound to RNA....
Biology Products: