Navigation Links
Faster diagnostics through cheap, ultra-portable blood testing
Date:9/1/2011

cules called aptamers to latch on to free-floating proteins in the blood. Aptamers are custom-made and commercially available short strands of nucleic acid. In some ways, they mimic the natural behavior of antibodies found in the body because they connect to one type of molecule, and only one type. Specific aptamers can be used to search for target compounds ranging from small molecules such as drugs and dyes to complex biological molecules such as enzymes, peptides, and proteins.

Aptamers, however, have advantages over antibodies in clinical testing. They are able to tolerate a wide range of pH (acid and base environments) and salt concentrations. They have high heat stability, are easily synthesized, and cost efficient.

For their demonstration, the researchers chose thrombin and thrombin-binding aptamers. Thrombin is a naturally occurring protein in humans that plays a role in clotting.

The researchers affixed the aptamers to a sensor surface, in this case a glass slide coated with a nanoscale layer of gold. As the blood sample is applied to the testing surface, the aptamer and their corresponding proteins latched together.

The next step is to actually determine if the couples pairing was successful. To make this detection, the researchers used a real-time optical sensing technique known as Surface Plasmon Resonance (SPR). A surface plasmon is a "virtual particle," created by the wave-motion of electrons on the surface of the sensor. If the protein is present and has bound to the aptamer, conditions for which resonance will occur at the gold layer will change. This resonance change is detected through a simple reflectance technique that is coupled to a linear detector.

"By monitoring these conditions, we can quantify the amount of the target protein that is present; even at very low concentrations," says Cameron. "This approach is very robust in that unique aptamers for almost any given protein can be identified. T
'/>"/>

Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Research finds Greenland glacier melting faster than expected
2. Disordered networks synchronise faster than small world networks
3. Sharper, deeper, faster
4. UBC megapixel DNA replication technology promises faster, more precise diagnostics
5. Faster 3-D nanoimaging a possibility with full color synchrotron light
6. Again, but faster! The spectacular courtship dance of a tiny bird
7. Evolution drives many plants and animals to be bigger, faster
8. Operation makes dementia patients faster and smarter
9. Faster development might have its costs
10. Study finds fisheries management makes coral reefs grow faster
11. Major advance in MRI allows much faster brain scans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Faster diagnostics through cheap, ultra-portable blood testing
(Date:7/10/2014)... COMMACK, N.Y. , July 2, 2014 ... Inc. (ABD) to announce the appointment of the world-renowned ... its Board of Directors. Dr. Ginsburg, with ... two facilities: NY Presbyterian Hospital and Good Samaritan Regional ... Breathing Pacemaker since the late 1980,s and is considered ...
(Date:7/10/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/h7h8lq/gesture ) has ... Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, ... to their offering http://photos.prnewswire.com/prnh/20130307/600769 ... Sensing Market to Grow Exponentially. Touch-less sensing applications ... companies were unable to leverage this technology due ...
(Date:7/10/2014)... 2014 Fingerprint Cards, (FPC,s) ... win (DW). An Asian OEM has selected FPC1021 for a ... in August 2014.   FPC is proud to ... a planned date for start of mass production in August ... SEK 5M, for delivery in the first half of July. ...
Breaking Biology News(10 mins):Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... This release is available in German . ... or malaria treatment could soon become easier - thanks to ... Institute of Molecular Physiology in Dortmund aim to facilitate the ... Scaffold Hunter, acts as a tool for navigating chemical space. ...
... Palo Alto, CAWith the information explosion, it,s ... interactions that proteins have with each other and ... interactive, so-called membrane proteins regulate nutrients and water ... interface with neighboring cells and within the cell. ...
... generates electricity can also remove 90 percent of salt from ... researchers from China and the U.S. Clean water for ... some parts of the world. Its availability in the future ... using either a reverse osmosis process -- one that pushes ...
Cached Biology News:Navigating in the ocean of molecules 2Navigating in the ocean of molecules 3Carnegie donates landmark clones to biology 2Wastewater produces electricity and desalinates water 2Wastewater produces electricity and desalinates water 3
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
(Date:7/10/2014)... recent study by researchers at the University of ... physical mechanisms governing the interplay of spin and ... limits of ultrafast spintronic devices for data storage ... charge as well as spin-angular momentum. In a ... there is no spin current," explained David Cahill, ...
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused ... analysis of tumor cells in the bloodstream, today announced ... decision support application powered by CollabRx, Inc. , ... test, Therapy Finder will provide breast cancer patients and ...
Breaking Biology Technology:Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3
... Accera, Inc., a biotech company specializing in ... to the Alzheimer,s Foundation of America (AFA) for sponsorship ... Alzheimer,s Disease Awareness Month.  These funds will be used ... individuals with Alzheimer,s disease (AD) and their families, especially ...
... SHELTON, Conn., Oct. 24, 2011 Modern Plastics, one ... shapes and medical-grade plastics, has become ISO 13485-2003 certified ... Tube, Film and Resin. "This is ... customer commitment to service and quality," said Bing J. ...
... Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in ... the European Medicines Agency,s (EMA) Committee for Medicinal Products ... that Glybera (alipogene tiparvovec) is not approvable at this ... recommendation of CHMP Rapporteurs, the Scientific Advisory Group (SAG), ...
Cached Biology Technology:Accera, Inc. Donates $50,000 to the Alzheimer's Foundation of America for National Memory Screening Day 2Accera, Inc. Donates $50,000 to the Alzheimer's Foundation of America for National Memory Screening Day 3Amsterdam Molecular Therapeutics Receives Opinion on Re-examination of Glybera® Marketing Authorisation Application 2Amsterdam Molecular Therapeutics Receives Opinion on Re-examination of Glybera® Marketing Authorisation Application 3
... E-PAGE Gels easier and more efficient by ... several types of pre-cut pre-assembled membrane/filter paper ... 13.5 cm E-PAGE Gels*. The available nitrocellulose ... western transfer of proteins (Figure 1 Table ...
... carbohydrate analysis standard is a lyophilized ... sugar alcohol; molecular weights range from ... provided for use with the Aminex ... kit for column testing or semiquantitative ...
... kit was tested on rat tissue extracts (liver, ... ( S. cerevisae ) extract. It was also ... and cell lines. Application: A simple and reliable ... based on the detection of the inorganic phosphate ...
... is the condition in which a lack ... and the various antioxidants. Oxidative stress ... of several diseases, including artherosclerosis, chronic inflammatory ... several antioxidant systems that are very important ...
Biology Products: