Navigation Links
Faster, more accurate, more sensitive
Date:12/25/2011

Lightning fast and yet highly sensitive: HHblits is a new software tool for protein research which promises to significantly improve the functional analysis of proteins. A team of computational biologists led by Dr. Johannes Sding of LMU's Genzentrum has developed a new sequence search method to identify proteins with similar sequences in databases that is faster and can discover twice as many evolutionarily related proteins as previous methods. From the functional and structural properties of the identified proteins conclusions can then be drawn on the properties of the protein to be analysed. "Our method will expand the scope and power of sequence analysis, which will in turn facilitate the experimental elucidation of the structure and function of many proteins", says Sding, who is also a member of the Center for Integrated Protein Science Munich (CiPSM). (Nature Methods, 25.12.2011)

Proteins are involved in nearly all biochemical processes of life. The functions that a protein performs largely depend on the sequence of the 20 amino acid building blocks and on the three-dimensional spatial structure into which this sequence of amino acids folds. From the similarity of protein sequences, bioinformatic methods can predict their evolutionary relatedness, which in turn implies similar structure and functions. Therefore, proteins to be studied are standardly subjected to a sequence search, in which their sequence is compared with millions of sequences in public databases with annotated structures and functions. The properties of the protein of interest can then be inferred from the properties of the proteins with similar sequences, including its structure and functions. The general relationship between sequence and function makes it possible to predict the structure and function of a given protein by comparing its sequence with those of proteins of known structure/function. Publicly accessible databases exist in which the sequences of known prote
'/>"/>

Contact: Simon Kirner
simon.kirner@lmu.de
49-892-180-3174
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UBC megapixel DNA replication technology promises faster, more precise diagnostics
2. ASU scientists develop universal DNA reader to advance faster, cheaper sequencing efforts
3. Boston University reseachers develop faster, cheaper DNA sequencing method
4. Faster, cheaper way to find disease genes in human genome passes initial test
5. Faster, more cost-effective DNA test for crime scenes, disease diagnosis
6. Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
7. Orca ears inspire Stanford researchers to develop ultrasensitive undersea microphone
8. Oceans harmful low-oxygen zones growing, are sensitive to small changes in climate
9. LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension
10. Globalized economy more sensitive to recessions
11. New artificial skin could make prosthetic limbs and robots more sensitive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... found in forests has created a thriving habitat for ... new University of Georgia study has found. , Japanese ... the early 1900s, is one of the most pervasive ... dozen states in the past century, particularly in the ... can survive in widely diverse ecosystems and has been ...
(Date:8/27/2014)... The IEEE Engineering in Medicine and Biology Society (EMBS) ... (EMBC,14), this year being held at the Sheraton Chicago ... , from Tuesday, August 26 through Saturday, August 30. ... in science, medicine, and engineering are registered to attend. ... This year,s conference theme is Discovering, Innovating, ...
(Date:8/27/2014)... puts into doubt the long-standing belief that a deficiency ... plays a central role in depression. In the ... mice lacking the ability to make serotonin in their ... wisdom) did not show depression-like symptoms. , Donald ... Medical Center and Wayne State University School of Medicine ...
Breaking Biology News(10 mins):More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3New study throws into question long-held belief about depression 2
... receive the Albert Maucher Prize by the Deutsche Forschungsgemeinschaft ... research findings. The prize will be awarded on 8 ... of Biogeochemistry and Marine Chemistry at the University of ... anaerobic methane oxidation, and Dr. David Dolejs from the ...
... Parasites can decimate amphibian populations, but one University of ... spurring the evolution of new and sometimes bizarre breeding strategies. ... of Ecology Savannah River Ecology Lab, explains that most amphibians ... and then make their way onto land as adults and ...
... with Fingerprint Sensor Recognized in the ... Enabling Technologies Product Category, ... SYNA ), a leading developer of human interface solutions ... SecurePad(TM) solution has been selected as a CES Innovations ...
Cached Biology News:2007 Albert Maucher Prize for Outstanding Young Geoscientists 2Parasites might spur evolution of strange amphibian breeding habits 2Synaptics SecurePad(TM) Selected as CES Innovations 2008 Design and Engineering Award Honoree 2Synaptics SecurePad(TM) Selected as CES Innovations 2008 Design and Engineering Award Honoree 3
(Date:8/27/2014)... , Aug. 27, 2014 Tris Pharma, a ... technologies, today announced that it has been selected as ... Industry Association,s 2014 Awards for Excellence competition ... an independent panel of judges from SCORE (Counselors to ... winners will be honored at a gala event to ...
(Date:8/27/2014)... August 27, 2014 BIOEQUA, an innovative ... the use of a handheld spray, has made its ... States. , The brand began with an unexpected ... were surprised to learn that the application of nanospray ... small and delivered directly to skin's basal layer. This ...
(Date:8/27/2014)... City, OR (PRWEB) August 27, 2014 ... Report, “Consolidation continues to reshape the look and feel ... nutrition. Consumer demand for higher-quality ingredients will push for ... North American market have experienced strong market growth in ... ethical attributes in their food and cosmetics to fit ...
(Date:8/27/2014)... WriteResult, LLC – a premier provider of ... superiority when it comes to meeting the needs of ... of their most recent study closeout on-time and with ... digital writing platform to collect Patient Reported Outcomes electronically ... drew data from a number of assessments including the ...
Breaking Biology Technology:Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2
... by thought, brain-powered wheelchairs, and neuro-prosthetic limbs. But powering ... prevents the technology from being of much use to ... Milln and his team at the Ecole Polytechnique Fdrale ... the system so that it learns about its user, ...
... COLUMBIA, Md., Feb. 17, 2011 Martek Biosciences Corporation ... innovation, development, production and sales of high-value products from microbial ... today that it has been inducted into the inaugural ... program under the U.S. Small Business Administration. Martek Biosciences ...
... NEW YORK, Feb. 17, 2011 AMDeC, LLC ... Program to include services offered by BioStorage Technologies, ... biomaterial storage, and cold chain logistics.  This partnership ... preferred pricing on biomaterial storage and relocation services ...
Cached Biology Technology:Taking brain-computer interfaces to the next phase 2Martek Biosciences Inducted into Small Business Innovation Research (SBIR) Hall of Fame 2Martek Biosciences Inducted into Small Business Innovation Research (SBIR) Hall of Fame 3AMDeC's Vendor Program Expands Focus with Addition of BioStorage Technologies, Offering Preferred Pricing on Tissue Storage and Cold Chain Logistics Services 2AMDeC's Vendor Program Expands Focus with Addition of BioStorage Technologies, Offering Preferred Pricing on Tissue Storage and Cold Chain Logistics Services 3AMDeC's Vendor Program Expands Focus with Addition of BioStorage Technologies, Offering Preferred Pricing on Tissue Storage and Cold Chain Logistics Services 4