Navigation Links
Faster, more accurate, more sensitive
Date:12/25/2011

Lightning fast and yet highly sensitive: HHblits is a new software tool for protein research which promises to significantly improve the functional analysis of proteins. A team of computational biologists led by Dr. Johannes Sding of LMU's Genzentrum has developed a new sequence search method to identify proteins with similar sequences in databases that is faster and can discover twice as many evolutionarily related proteins as previous methods. From the functional and structural properties of the identified proteins conclusions can then be drawn on the properties of the protein to be analysed. "Our method will expand the scope and power of sequence analysis, which will in turn facilitate the experimental elucidation of the structure and function of many proteins", says Sding, who is also a member of the Center for Integrated Protein Science Munich (CiPSM). (Nature Methods, 25.12.2011)

Proteins are involved in nearly all biochemical processes of life. The functions that a protein performs largely depend on the sequence of the 20 amino acid building blocks and on the three-dimensional spatial structure into which this sequence of amino acids folds. From the similarity of protein sequences, bioinformatic methods can predict their evolutionary relatedness, which in turn implies similar structure and functions. Therefore, proteins to be studied are standardly subjected to a sequence search, in which their sequence is compared with millions of sequences in public databases with annotated structures and functions. The properties of the protein of interest can then be inferred from the properties of the proteins with similar sequences, including its structure and functions. The general relationship between sequence and function makes it possible to predict the structure and function of a given protein by comparing its sequence with those of proteins of known structure/function. Publicly accessible databases exist in which the sequences of known prote
'/>"/>

Contact: Simon Kirner
simon.kirner@lmu.de
49-892-180-3174
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UBC megapixel DNA replication technology promises faster, more precise diagnostics
2. ASU scientists develop universal DNA reader to advance faster, cheaper sequencing efforts
3. Boston University reseachers develop faster, cheaper DNA sequencing method
4. Faster, cheaper way to find disease genes in human genome passes initial test
5. Faster, more cost-effective DNA test for crime scenes, disease diagnosis
6. Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
7. Orca ears inspire Stanford researchers to develop ultrasensitive undersea microphone
8. Oceans harmful low-oxygen zones growing, are sensitive to small changes in climate
9. LSUHSC study IDs proteins regulating water retention in salt-sensitive hypertension
10. Globalized economy more sensitive to recessions
11. New artificial skin could make prosthetic limbs and robots more sensitive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , Kina, 31. juli 2015 Den 10. ... afholdt af BGI fra den 22. - 25. oktober i ... Konferencen fejrer sin 10-års fødselsdag i år. Siden starten ... indflydelsesrige årlige møder på ,omik,-feltet, og er en af ... ICG-10 fokuserer på nylige gennembrud og fremskridt ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale ... von BGI veranstaltet und findet vom 22. bis ... , statt. Die Konferenz ... ihrem Start 2006 ist die ICG weltweit zu ... geworden. Sie ist eines der dynamischsten, enthusiastischsten und ...
(Date:7/27/2015)... 2015   Zynx Health ™, the market ... solutions, today announced that its ZynxCarebook ™ ... Android smartphones and tablets. With this expansion, care ... use ZynxCarebook to securely exchange messages and share ... transitions to other care settings, and improve clinical ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... long speculated that high diabetes rates among Native Americans may ... ancient hunter-gatherers store fat for survival during famine may contribute ... a new analysis of fossil feces from an Arizona cave ... do with famine and much more to do with the ...
... FRANCISCO, July 24, 2012 -- The San Francisco State ... a deadly fly parasite want people across the United ... their own backyards. Today SF State Professor of ... Department of Biology and the Center for Computing for ...
... diabetes study at the University of Leicester has discovered that ... origin) have higher levels of blood sugar than white Europeans ... The study of 4,688 white Europeans and 1,352 South Asians ... of Leicester, Department of Cardiovascular Sciences, and was published in ...
Cached Biology News:Feces fossils yield new insights into ancient diets and 'thrifty genes' 2Feces fossils yield new insights into ancient diets and 'thrifty genes' 3Citizen scientists needed for SF State's 'ZomBee Watch' 2
(Date:8/3/2015)... 2015  Halozyme Therapeutics, Inc. (NASDAQ: HALO ) ... second quarter 2015 on Monday, August 10, 2015 at ... , president and chief executive officer, will lead the ... financial results for the second quarter 2015. ... section of Halozyme,s corporate website and a recording will ...
(Date:8/3/2015)... Aug. 3, 2015  ArroGen Group, an integrated ... Fingerprint Molecular Identification™ (FMID) technology Aug. 2-8 at ... Sacramento, Calif. ... enable law enforcement agents, district attorneys and government ... suspects. By analyzing chemical residues on ...
(Date:8/3/2015)... , August 3, 2015 ... Portland Hospital waved the shortfall of ... could stand normally for the first time. ... (Photo: http://photos.prnewswire.com/prnh/20150803/254229 ) The Selective ... legs allowing him to carry out his wish to ...
(Date:8/3/2015)... Aug. 3, 2015  MiMedx Group, Inc. (NASDAQ: ... amniotic tissue and patent-protected processes to develop and market ... Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental sectors of ... 35 th Annual Canaccord|Genuity Growth Conference in ... Chairman and CEO, William C. Taylor , President ...
Breaking Biology Technology:Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2ArroGen Previews New Fingerprint Molecular Identification Technology 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2
... CAMBRIDGE, Mass., April 10 Biopure,Corporation (Nasdaq: ... Vitale,Caturano & Company, Ltd as its independent auditor., ... directors made its selection,after a review of audit ... size and requirements., Based in Boston, Massachusetts, ...
... systemic lupus erythematosus and lupus-like disorders ... ... DENVER, April 10 Corgenix Medical Corporation,(OTC Bulletin Board: CONX) ... Drug Administration (FDA) for the Company,s IgG,Anti-AtherOx(R) Test Kit. This ...
... been proposed for regenerative medicine and tissue replacement after ... to efficiently develop into the desired specific cell type ... neurons now limits the potential clinical utility of ... within aggregates of embryonic stem cells via biodegradable microspheres ...
Cached Biology Technology:Corgenix Announces FDA Clearance for IgG Anti-AtherOx(R) Test Kit 2Corgenix Announces FDA Clearance for IgG Anti-AtherOx(R) Test Kit 3Method to deliver molecules within embryonic stem cells improves differentiation 2Method to deliver molecules within embryonic stem cells improves differentiation 3
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (F1676) or contact customer s...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (E6027) or contact customer s...
... refractive index chromatography system, uses the highly ... Data processing is provided by the CE 4900 ... high pressure CE 4100 dual piston pump. ... The system can be upgraded to provide ...
capacity 250 mL...
Biology Products: