Navigation Links
Faster, cheaper way to find disease genes in human genome passes initial test
Date:8/17/2009

University of Washington (UW) researchers have successfully developed a novel genome-analysis strategy for more rapid, lower cost discovery of possible gene-disease links. By saving time and lowering expenses, the approach makes it feasible for scientists to search for disease-causing genes in people with the same inherited disorder but without any family ties to each other.

The strategy also might be extended to common medical conditions with complex genetics by making it more cost-effective and efficient to study the genomes of large groups of people.

Such large-scale research hasn't been undertaken because it has been prohibitively expensive, cumbersome, and time-consuming to sequence, compare and interpret entire human genomes.

The study, published today in Nature by lead author Sarah B. Ng, a graduate student in the UW Department of Genome Sciences, was conducted as a proof-of-concept to see if a more targeted analysis and newer technology could identify candidate genes for Mendelian disorders. These are diseases like cystic fibrosis or sickle cell anemia that are caused by a mutation in a single gene and are passed along through generations in a simple inheritance pattern. In this study, the rare Mendelian disorder picked to evaluate the strategy in unrelated, affected individuals was Freeman-Sheldon syndrome.

The study's senior author is Jay Shendure, UW assistant professor of genome sciences. In addition to the Shendure lab, the UW labs of Deborah Nickerson, Genome Sciences; Michael Bamshad, Pediatrics; and Evan Eichler, Genome Sciences, played key roles in the collaborative study.

To make progress in disease genetics, new strategies such as this are vital. Shendure gave an example: "The genetics of thousands of rare diseases remains unsolved because sufficient numbers of families with individuals affected by those disorders are not easily available. Even with such families, mapping and identifyin
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Faster, more cost-effective DNA test for crime scenes, disease diagnosis
2. TGen investigators devise faster, cheaper way of analyzing the human genome
3. Tires made from trees -- better, cheaper, more fuel efficient
4. A quicker, cheaper SARS virus detector -- one easily customizable for other targets
5. New cheaper method for mapping disease genes
6. Pharmaceutical breakthrough may make a range of drugs cheaper and more available
7. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
8. Cheaper drugs now closer to realization with new DropArray technology
9. The power of multiples: Connecting wind farms can make a more reliable - and cheaper - power source
10. Mothers immune system may block fetal treatments for blood diseases
11. Carnegie Mellon develops innovative method to detect genetic causes of complex diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Faster, cheaper way to find disease genes in human genome passes initial test
(Date:9/29/2014)... 2014 -- Plants have a symbiotic relationship with ... extract nutrients and defend against invaders an ... and vegetables. Now, scientist have discovered that plants ... thus ensuring that sprouting plants are colonized from ... Notre Dame, presented their findings today at the ...
(Date:9/29/2014)... from 2009, "human activities in this area of the world ... is increasingly grown for use as a cooking oil and ... has become the most widely produced edible oil in the ... that of soybean oil. , The environmental effects of such ... grow the crop, and the preferred method is fire. The ...
(Date:9/29/2014)... home should use ventilation when cooking with a gas ... a new study showed an association between gas kitchen ... , "In homes where a gas stove was used ... higher than in homes where a gas stove was ... in the College of Public Health and Human Sciences ...
Breaking Biology News(10 mins):Plants prepackage beneficial microbes in their seeds 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... previously developed to measure a toxin found in tobacco ... in people suffering from spinal cord injuries and multiple ... The toxin, called acrolein, is produced in the body ... biochemical events thought to worsen the injury,s severity. Acrolein ...
... structure called "the microtubule network" is a crucial part ... system within nerve cells, carrying essential proteins and enabling ... and Parkinson,s, this network breaks down, hindering motor abilities ... of Tel Aviv University,s Sackler Faculty of Medicine has ...
... PHILADELPHIA (June 13, 2013)Twenty-two of the nation,s most ... Biomedical Sciences by The Pew Charitable Trusts today. ... researching the basis of perplexing health problems such ... new scholars join a prestigious community of researchers ...
Cached Biology News:Testing method promising for spinal cord injuries, multiple sclerosis 2Testing method promising for spinal cord injuries, multiple sclerosis 3A peptide to protect brain function 2From autism to diabetes to Parkinson's disease 2From autism to diabetes to Parkinson's disease 3
(Date:9/29/2014)... 29, 2014 Burnham Securities Inc. ("Burnham"), ... ("TCG"), a leader in healthcare venture development and ... alliance to expand the range of services each ... alliance, Burnham Securities will be supported by a ... and management in healthcare industry to build a ...
(Date:9/29/2014)... ZIONA, Israel , September 29, ... stage company developing novel immunomodulators for severe infections, today ... ( BARDA ) has awarded Atox Bio with a ... for the development of AB103 to treat Necrotizing Soft ... and public health threats that end in sepsis. ...
(Date:9/29/2014)... 2014 Westbridge Agricultural Products announced ... a highly effective new tool for organic growers. ... spectrum contact herbicide for post-emergent, non-selective weed control ... crops. The formulation is an emulsifiable concentrate that ... Institute (OMRI) for use in organic food production. ...
(Date:9/27/2014)... interdisciplinary team of University of Pennsylvania researchers has ... sequencing toward measuring other nanoscopic structures. By passing ... in a membrane, the team was able to ... , Their findings suggest new ways of using ... objects at the smallest scale. , The ...
Breaking Biology Technology:Burnham Securities Inc. and The Channel Group Form Healthcare Alliance 2Burnham Securities Inc. and The Channel Group Form Healthcare Alliance 3Atox Bio Awarded Contract Worth up to $24 Million for the Development of AB103 by the Biomedical Advanced Research and Development Authority (BARDA) 2Westbridge Receives EPA Approval for Its New SUPPRESS™ Herbicide EC 2Penn team studies nanocrystals by passing them through tiny pores 2Penn team studies nanocrystals by passing them through tiny pores 3Penn team studies nanocrystals by passing them through tiny pores 4
... ... Processing Leader Applies For Microfluidics Reaction Technology™ (MRT) Patent in Japan , ... Newton, MA ... along with its exclusive Japanese distributor, POWREX Corporation, it has introduced Microfluidics Reaction ...
... ... ... offer a live, interactive Webinar on the benefits and value of implementing MODA-EM™, on Tuesday, ... will feature Marvin Thompson, Manager, Quality Operations at Talecris, and Bob Toal, Vice President at ...
... ... takes a giant step forward with two industry leading companies creating an integration ... ... 19, 2010 -- The world-class preclinical software developer PDS Pathology Data System (PDS) ...
Cached Biology Technology:Microfluidics and POWREX Launch Revolutionary Continuous Pharmaceutical Manufacturing Technology in Japan 2Microfluidics and POWREX Launch Revolutionary Continuous Pharmaceutical Manufacturing Technology in Japan 3Live Webinar: Paperless QC Micro Implemented by Talecris Biotherapeutics 2Live Webinar: Paperless QC Micro Implemented by Talecris Biotherapeutics 3Mettler Toledo and PDS Pathology Data Systems Integrate Powerful Solutions for Faster and More Accurate Preclinical Studies 2Mettler Toledo and PDS Pathology Data Systems Integrate Powerful Solutions for Faster and More Accurate Preclinical Studies 3