Navigation Links
Fast synthesis could boost drug development
Date:3/18/2014

CAMBRIDGE, MA -- Small protein fragments, also called peptides, are promising as drugs because they can be designed for very specific functions inside living cells. Insulin and the HIV drug Fuzeon are some of the earliest successful examples, and peptide drugs are expected to become a $25 billion market by 2018.

However, a major bottleneck has prevented peptide drugs from reaching their full potential: Manufacturing the peptides takes several weeks, making it difficult to obtain large quantities, and to rapidly test their effectiveness.

That bottleneck may soon disappear: A team of MIT chemists and chemical engineers has designed a way to manufacture peptides in mere hours. The new system, described in the March 21st issue of journal ChemBioChem, could have a major impact on peptide drug development, says Bradley Pentelute, an assistant professor of chemistry and leader of the research team.

"Peptides are ubiquitous. They're used in therapeutics, they're found in hydrogels, and they're used to control drug delivery. They're also used as biological probes to image cancer and to study processes inside cells," Pentelute says. "Because you can get these really fast now, you can start to do things you couldn't do before."

The lead author of the paper is Mark Simon, a graduate student in Pentelute's lab. Other authors include Klavs Jensen, head of MIT's Department of Chemical Engineering, and Andrea Adamo, a research associate in chemical engineering.

Accelerated manufacturing

Therapeutic peptides usually consist of a chain of 30 to 40 amino acids, the building blocks of proteins. Many universities, including MIT, have facilities to manufacture these peptides, but the process usually takes two to six weeks, using machines developed about 20 years ago.

These machines require about an hour to perform the chemical reactions needed to add one amino acid to a chain. To speed up the process, the M
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The genome of sesame sheds new lights on oil biosynthesis
2. New research indicates causal link between vitamin D, serotonin synthesis and autism
3. Substance in photosynthesis was at work in ancient, methane-producing microbes
4. Protein synthesis and chance
5. Quantum mechanics explains efficiency of photosynthesis
6. Targeted synthesis of natural products with light
7. Rensselaer researchers to map step-by-step mechanism of photosynthesis
8. In plant photosynthesis, scientists see clues for improving solar energy cells
9. Photosynthesis: Membranes in tight corners
10. UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis
11. Science synthesis to help guide land management of nations forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... release is available in German . ... players in the natural nitrogen cycle on Earth and ... bacteria were thought to depend on nitrite as their ... by Holger Daims, a microbiologist at the University of ... hydrogen as an alternative source of energy. The oxidation ...
(Date:8/29/2014)... twist them, fold them: modern materials that are light, ... as artificial skin or electronic paper. , Making such ... but a new way of working with copper nanowires ... , Previous success in the field of ultra-lightweight ... precious gold and silver nanowires. , By turning ...
(Date:8/28/2014)... handful of bacterial culprits that may drive inflammatory bowel ... using patients, own intestinal immune responses as a guide. ... journal Cell . , Trillions of bacteria exist ... role in the development and progression of IBD. Yet ... species affect a person,s susceptibility to IBD and its ...
Breaking Biology News(10 mins):Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Copper shines as flexible conductor 2Yale study identifies possible bacterial drivers of IBD 2
... A team of Howard Hughes Medical Institute (HHMI) scientists has ... able to turn off genes selectively to control critical events ... molecular images of the structure of Dicer, an enzyme that ... which is reported in the January 13, 2005, issue of ...
... geochemists from the University of Southern California and Rice ... that could power spy drones that fit in the ... long been interested in micro-scale air vehicles ?some as ... the lack of a suitable, compact power source. With ...
... regenerative medicine, researchers at Rice University have discovered a new ... that the cells themselves produce a growth matrix that is ... appears online this week in the Proceedings of the National ... science ?researchers found they could coax bone cells into produce ...
Cached Biology News:Molecule does more than slice and dice RNA 2Molecule does more than slice and dice RNA 3Molecule does more than slice and dice RNA 4USC, Rice to develop bacteria-powered fuel cells 2Findings advance use of adult stem cells for replacement bone 2
(Date:8/28/2014)... New York, NY (PRWEB) August 28, 2014 ... has renewed its long term partnership with PTI ... to provide clients with state of the art leak ... state of the art instruments currently available. As part ... a new High Voltage Leak Detection Instrument ...
(Date:8/27/2014)... Austin, TX (PRWEB) August 27, 2014 ... $6 million in Series B funding and secured Otter ... and investment capital will accelerate commercialization of GGI’s Agriplier™ ... multiple crop types. , “Since our first meeting, ... commitment to the biological product space,” said Alan Sobba, ...
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
(Date:8/27/2014)... Aug. 27, 2014   MSC , a healthcare ... today announced the appointment of Mary Beth Loesch ... 28 years of experience preparing companies for rapid growth ... Executive Vice President of Corporate Development and Healthcare. In ... business , as well as corporate strategy and marketing. ...
Breaking Biology Technology:Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3MSC names Mary Beth Loesch President and CEO 2
... Force, a web based CTMS (Clinical Trial Management ... selected and deployed Clinical Force to manage worldwide ... Regulatory/Ethics Management, CRF Tracking, Visit Reports, and Site ... Future phases of our project will include integration ...
... Inc. (Nasdaq: IDIX ) announced today that management ... programs at the Canaccord Adams Hepatitis C Conference on Tuesday, ... Barclay New York Hotel in New York City.The live and ... of Events" in the Idenix Investor Center at ...
... YORK, April 3 /PRNewswire-Asia-FirstCall/ -- China Agri-Business, Inc.,(OTC ... products through its operating company in China, announced ... , Revenue for the ... of 3.8% as compared to $3,037,414 for the ...
Cached Biology Technology:Gemin X Pharmaceuticals Selects and Deploys Clinical Force CTMS 2Gemin X Pharmaceuticals Selects and Deploys Clinical Force CTMS 3China Agri-Business Announces 2008 Operating Results 2China Agri-Business Announces 2008 Operating Results 3China Agri-Business Announces 2008 Operating Results 4China Agri-Business Announces 2008 Operating Results 5
... a chemically modified form of AmpliTaq® DNA ... to the enzyme, the enzyme is inactive. ... thermal cycling (when the reaction is going ... inactive. The result is that mis-primed primers ...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
Ps-Aeruginosa (IgG) -Ab EIA Sample Size: 100 l...
Ps-Aeruginosa (IgA) -Ab EIA Sample Size: 100 l...
Biology Products: