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Fast synthesis could boost drug development
Date:3/18/2014

CAMBRIDGE, MA -- Small protein fragments, also called peptides, are promising as drugs because they can be designed for very specific functions inside living cells. Insulin and the HIV drug Fuzeon are some of the earliest successful examples, and peptide drugs are expected to become a $25 billion market by 2018.

However, a major bottleneck has prevented peptide drugs from reaching their full potential: Manufacturing the peptides takes several weeks, making it difficult to obtain large quantities, and to rapidly test their effectiveness.

That bottleneck may soon disappear: A team of MIT chemists and chemical engineers has designed a way to manufacture peptides in mere hours. The new system, described in the March 21st issue of journal ChemBioChem, could have a major impact on peptide drug development, says Bradley Pentelute, an assistant professor of chemistry and leader of the research team.

"Peptides are ubiquitous. They're used in therapeutics, they're found in hydrogels, and they're used to control drug delivery. They're also used as biological probes to image cancer and to study processes inside cells," Pentelute says. "Because you can get these really fast now, you can start to do things you couldn't do before."

The lead author of the paper is Mark Simon, a graduate student in Pentelute's lab. Other authors include Klavs Jensen, head of MIT's Department of Chemical Engineering, and Andrea Adamo, a research associate in chemical engineering.

Accelerated manufacturing

Therapeutic peptides usually consist of a chain of 30 to 40 amino acids, the building blocks of proteins. Many universities, including MIT, have facilities to manufacture these peptides, but the process usually takes two to six weeks, using machines developed about 20 years ago.

These machines require about an hour to perform the chemical reactions needed to add one amino acid to a chain. To speed up the process, the M
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Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

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