Navigation Links
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
Date:11/10/2013

, the research team identified more than 2,600 HARs. Then, they created a program called EnhancerFinder to whittle down that list to just the HARs were likely to be enhancers.

"EnhancerFinder is a machine-learning algorithm that takes in basic genetic informationa HAR sequence, known evolutionary patterns, other functional genomics dataand returns a prediction of that HAR's function," explained Tony Capra, PhD, the study's lead author. "Using this approach, we predicted that nearly eight hundred HARs act as enhancers at a specific point during embryonic development. Confirming this prediction for several dozen HARs, our next goal was to see whether any of these HARs enhanced patterns of gene activation that were uniquely human."

Additional analyses revealed five such HARs, which were active in both human and chimpanzee genomes, but which activated genes in different embryonic regions. For example, the human versions of HARs 2xHAR.164 and 2xHAR.170 are active in a region of the brain between the midbrain and hindbrain, while the chimp versions are not. This so-called "gain of function" of these two HARs in human embryos may point to differences in the development of key brain regions such as the cerebellum, which is known to regulate not only motor control but may also regulate higher cognitive functions, such as language, fear and pleasure.

"These results, while preliminary, offer an unprecedented glimpse into how very recent changes to the human genome have modified the genetic programs that control embryonic development to potentially yield different results," said Dr. Capra. "We anticipate that if we were to look at the activity of HARs that are enhancers during later developmental stages, we would see even more differences between humans and chimpanzees."

"It's been 10 years since the Human Genome Project was declared 'complete,' but the amount of genomic knowledge we've gleaned since thenin large part due to advances in bioi
'/>"/>

Contact: Anne Holden
anne.holden@gladstone.ucsf.edu
415-734-2534
Gladstone Institutes
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Long-term research reveals causes and consequences of environmental change
2. New approach to spell checking gene sequences
3. Revolutionary project will obtain entire genome sequences in fight against Alzheimers
4. Research reveals contrasting consequences of a warmer Earth
5. DNA sequences need quality time too - guidelines for quality control published
6. Computers taught to ID regulating gene sequences
7. Global warming may have severe consequences for rare Haleakalā silverswords
8. Global warming may have severe consequences for rare Haleakalā silverswords
9. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
10. College kids who dont drink milk could face serious consequences
11. Saving the parrots: Texas A&M team sequences genome of endangered macaw birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
(Date:11/4/2014)... University of Utah engineers developed the first room-temperature fuel ... electricity without needing to ignite the fuel. These new ... off-grid power and sensors. , A study of the ... Society journal ACS Catalysis . , Fuel cells ... a fuel and an oxygen-rich source such as air. ...
(Date:11/4/2014)... 2014   3D ... Fuel3D , a developer of 3D scanning ... totaling $6.4 million (£4 million). This funding builds on the ... year and paves the way for the commercial launch of ... funding round was led by Chimera Partners and will be ...
(Date:11/3/2014)...  NeuroSigma ® , Inc. (NeuroSigma), a ... on commercialization of its non-invasive Monarch ... neurological and neuropsychiatric disorders, announced today that the ... Notice of Allowance for Mexican Patent Application No. ... and the Regents of the University of California ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... the zebra finch genome, a new resource has been ... series published by BioMed Central, the open access publisher, ... part of the series, a study published in ... to steroid receptors and estrogen biosynthesis. Researchers writing in ...
... The "cradle" of new neurons in the adult brain is ... a tissue structure lining the lateral ventricles. This is where ... generating new neurons if needed. For many years now, the ... specific malignant brain tumors called gliomas, the most deadly type ...
... the Siberian arctic to get water and sediment samples, ... Tahoe or digging quagga mussels out of Lake Mead ... assistant professor of limnology and conservation ecology at the ... in Nevada lakes, including his prolific record of publication ...
Cached Biology News:Brain tumors: Tissue stem cell turning into tumor stem cell 2University of Nevada, Reno, professor receives exclusive American Fisheries Award of Excellence 2University of Nevada, Reno, professor receives exclusive American Fisheries Award of Excellence 3
(Date:11/26/2014)... YORK, NOVEMBER 21, 2014 (PRWEB) November 26, 2014 ... largest health-oriented communications network, today announced the organization has ... Annual Rx Club Awards. Digitas Health LifeBrands was honored ... while four other PHCG agencies received eight Awards of ... the creative aspects of pharmaceutical advertising and promotion. The ...
(Date:11/26/2014)... 26, 2014 The North America ... the market for detailed analysis of the growth ... to reach $616.3 million by 2018, growing at ... , Browse through the TOC of the North ... an idea of the in-depth analysis and industry ...
(Date:11/26/2014)... , Nov. 26, 2014 Space is one ... of space requires astronauts to maintain consistently high levels ... and prevent potential errors and accidents. Despite the importance ... about how cognition is affected by prolonged spaceflight, and ... Now, Penn Medicine researchers are poised to help the ...
(Date:11/26/2014)... The ETC (Emerging Technology Centers) ... announced today that applications for AccelerateBaltimore™ (AB) 2015 ... you have a big idea?,” asked ETC’s President ... about it. AccelerateBaltimore helps you and your big ... 13 weeks.” Interested game changers with “big ...
Breaking Biology Technology:Publicis Healthcare Wins 20 Rx Club Awards 2Publicis Healthcare Wins 20 Rx Club Awards 3The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
...  Generex Biotechnology Corporation (OTCBB: GNBT) announced today that it has ... This funding is structured as term loans of one year ... on the loans is payable monthly at the rate of ... will permit the Company to advance its redevelopment plans, and ...
... Calif. A research team led by physicists at the ... graphene" (BLG) that the researchers say is analogous to finding ... elastic material, is a one-atom thick sheet of carbon atoms ... and chicken wire-like structure, sheets of it lend themselves well ...
... MENLO PARK, Calif., Jan. 24, 2012 SRI International ... decrease the time required for researchers to construct genome-scale ... set of metabolic and physical processes that determine the ... are used to predict cell growth rate, combinations of ...
Cached Biology Technology:Generex Secures Commitments for $3.6M Capital Raise 2Generex Secures Commitments for $3.6M Capital Raise 3Bilayer graphene works as an insulator 2Bilayer graphene works as an insulator 3New Software from SRI Speeds Development of Genome-Scale Models for Drug and Fuel Research 2
... Chromatograph/Mass Spectrometer, utilizing many of the ... offers high throughput and excellent productivity, ... ratio. Like the GCMS-QP2010 Plus, the ... for optimum separation, 20 temperature ramps, ...
... XS uniquely combines a single-channel sample processing ... 8-channel bulk reagent dispenser all in one ... using disposable pipette tips, the Precision XS ... dispenser is available for transferring larger volumes. ...
... As the world of discovery races ever faster, ... on the fast track. So our constant focus ... accelerate your research. Thats why our Biomek 3000 ... thats as advanced as it is flexible. By ...
... MaxArray Rabbit Tissue Arrays contain 60 rabbit tissue ... package contains 4 unstained slides and 1 hematoxylin ... Each slide contains 15 different tissues from 4 ... samples per slide. Each tissue sample (or core) ...
Biology Products: