Navigation Links
Family history of liver cancer increases risk of developing the disease
Date:4/24/2012

A family history of liver cancer is reported to increase risk of developing hepatocellular carcinomas (HCC), independent of hepatitis according to findings published in the May issue of Hepatology, a journal of the American Association for the Study of Liver Diseases. The study also shows 70-fold elevated risk of HCC in those with liver cancer in the family and markers for hepatitis B (HBV) or hepatitis C (HCV).

Liver cancer ranks sixth in incidence and the third cause of mortality worldwide. According to the World Health Organization (WHO) liver cancer was responsible for 700,000 deaths in 2008, with HBV and HCV accounting for 78% of all cases of HCC. A vaccine for HBV has been available since 1982; however prior studies have shown familial clustering of HCC in East Asia where HBV is common. While medical evidence reports family history to be related to HCC risk, little is known of this relationship in non-Asian populations.

"There is a high incidence of liver cancer in southern Italy which is likely a result of a higher frequency of HCV in this area," explains Professor Carlo La Vecchia from the Istituto di Ricerche Farmacologiche ''Mario Negri" and the University of Milan in Italy. "Our study investigated the relationship between family history and liver cancer in a Western population."

The case-control study was carried out between January 1999 and July 2002, and included 229 cases of HCC and 431 hospital controls. HCC patients ranged in age from 43 to 84 years, providing survey information and blood samples. The control group included patients admitted to hospital for conditions not related to tumors. Analysis of data on family history and liver cancer updated to April 2011 was also performed.

Results show that 75% of the cases and 11% of controls showed evidence of HBV and HCV infection. Family history of liver cancer was associated to HCC risk after adjusting for chronic HBV and HCV. Compared to subjects without family history of liver cancer and no chronic HBV and HCV, researchers reported an odds ratio of 73 for those with both risk factors, indicating a 70-fold increased risk of developing HCC.

"Our findings confirm that individuals with a positive family history of liver cancer have three times higher risk of developing HCC," notes Professor La Vecchia. "Monitoring individuals with family history, particularly those with hepatitis markers, could help to identify HCC at an earlier stage, and hence potentially reduce mortality from HCC."


'/>"/>
Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. Merkin Family Foundation to fund next generation of Broad Institute scientists
2. New miniature grasshopper-like insect is first member of its family from Belize
3. Close family ties keep microbial cheaters in check, study finds
4. Do plants perform best with family or strangers? Researchers consider social interactions
5. Scientists determine family tree for most-endangered bird family in the world
6. Long bone shape: A family affair
7. Researchers at Cruces Hospital describe new syndrome of slight family intellectual disability
8. The risk of suffering from insomnia is 67 percent higher if a family member is insomniac
9. Highlights of upcoming conference on aldosterone & the ENaC/Degenerin family of ion channels
10. BUSM professor authors book on how knowledge about genes and family history can save lives
11. Methyl magnet genes can cause family cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... , March 15, 2016 ... report published by Transparency Market Research "Digital Door Lock Systems ... Forecast 2015 - 2023," the global digital door lock systems ... Mn in 2014 and is forecast to grow at a ... of micro, small and medium enterprises (MSMEs) across the world ...
(Date:3/11/2016)... Germany , March 11, 2016 http://www.apimages.com ... - Cross reference: Picture is available at AP Images ( http://www.apimages.com ... from DERMALOG will be used to produce the new refugee identity ... other biometric innovations, at CeBIT in Hanover ... scanner from DERMALOG will be used to produce the new refugee ...
(Date:3/9/2016)... NEW YORK , March 9, 2016 ... current and future states of the RNA Sequencing (RNA ... in segments such as instruments, tools and reagents, data ... Analyze various segments of the RNA-Sequencing market such ... RNA-Sequencing services Identify the main factors affecting each segment ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... May 27, 2016 At present, the ... in this space know that volatility is what makes this ... on ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: SNTA ), ... (NASDAQ: LPTN ), and Heat Biologics Inc. (NASDAQ: ... to the technical alerts for these stocks at: ...
(Date:5/26/2016)... and READING, England , ... ( http://www.indegene.com ), a leading global provider of ... pharmaceutical and healthcare organisations and TranScrip ( http://www.transcrip-partners.com ... support throughout the product lifecycle, today announced the ... of IntraScience.      (Logo: http://photos.prnewswire.com/prnh/20141208/720248 ...
(Date:5/26/2016)... May 26, 2016 Despite the volatility ... in this space. Today,s pre-market research on ActiveWallSt.com directs the ... Inc. (NASDAQ: RDUS ), Cerus Corp. (NASDAQ: ... ), and Five Prime Therapeutics Inc. (NASDAQ: FPRX ... at: http://www.activewallst.com/ On Wednesday, ...
(Date:5/26/2016)... CA (PRWEB) , ... May 26, 2016 , ... ... and manufacturing company, today announced several positive developments that position the Company for ... a result of the transaction, Craig F. Kinghorn has been appointed Chairman of ...
Breaking Biology Technology: