Navigation Links
Family genetic research reveals the speed of human mutation
Date:6/12/2011

This press release is available in French.

MONTREAL, June 12, 2011 A team of researchers have discovered that, on average, thirty mutations are transmitted from each parent to their child, revising previous estimations and revolutionizing the timescale we use to calculate the number of generations separating us from other species. "Your genome, or genetic code, is made up of six billion pieces of information, called nucleotides," explained co-lead author Philip Awadalla of the University of Montreal's Faculty of Medicine and Director of CARTaGENE. "Three billion come from each parent, and based on indirect evolutionary studies, we had previously estimated that parents would contribute an average of 100-200 mistakes in these pieces of information to their child. Our genetic study, the first of its kind, shows that actually much fewer mistakes or mutations are made." Awadalla published the study with co-author Matt Hurles of the Wellcome Trust Sanger Institute in Nature Genetics on June 12, 2011.

As mutations play a key role in the evolutionary process, geneticists will now revise the number of generations separating us from genetic relatives such as apes. "In principle, evolution is happening a third as slowly as previously thought," Awadalla said. The researchers made the discovery by looking at the complete genomes of two families a mother, father and their child. In another first, the findings enabled the team to determine whether men contribute more mutations to their offspring than women. The theory is that because mistakes are made during cell division and DNA replication, and males produces many millions more gametes (sperm) than women (eggs), more mutations would come from men compared to women. In one of their families, men contributed six times as many genetic errors to their children.

However, the research also showed a wide variation between families. "We saw that the number of mutations from the male was less than the number of mutations from the female in one of the families," Awadalla explained. "This doesn't mean that we're throwing the theory out the window, it simply means that the mutation rate is extremely variable from individual to individual, or even that some people have mechanisms that reduce the likelihood of mutations." He also noted that this finding would have important implications for research that attempts to tie specific genetic mutations to diseases.

Researchers will need to undertake further studies with more families to better understand just how variable the individual mutation rate is. "We also need to be looking at other kinds of mutations, such as structural variations within our genetic code," Awadalla said.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology news :

1. China fossil shows bird, crocodile family trees split earlier than thought
2. Family-Group Names in Coleoptera (Insecta) published by Pensoft
3. Sale of sports car benefits TGen cancer fund named for Jackson family
4. Insight into parasite family planning could help target malaria
5. Seedlings thrive with distant relatives, seeds with close family
6. Scripps Research team discovers new details about medically important protein family
7. For birds, the suburbs may not be an ideal place to raise a family
8. Better brain wiring linked to family genes
9. Researchers achieve a full film frame of a family of proteins essential for cell function
10. Recipe for family mealtimes calls for 3 ingredients in the right amounts
11. Family mealtimes play a role in health of children with asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... ... journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography (sEMG) ... tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase III ...
(Date:10/7/2017)... WA (PRWEB) , ... October ... ... industry leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution ... ProxiMeta Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C metagenome ...
(Date:10/6/2017)... Mass. (PRWEB) , ... October 06, 2017 , ... ... female entrepreneurship within the healthcare and technology sector at their fourth annual Conference ... panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early stage ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the leading ... around the world, is giving back to cancer research with a month-long promotion supporting ... Now through October 31, shoppers can use promo code PinkRibbon to get 10 percent ...
Breaking Biology Technology: