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Family genetic research reveals the speed of human mutation
Date:6/12/2011

This press release is available in French.

MONTREAL, June 12, 2011 A team of researchers have discovered that, on average, thirty mutations are transmitted from each parent to their child, revising previous estimations and revolutionizing the timescale we use to calculate the number of generations separating us from other species. "Your genome, or genetic code, is made up of six billion pieces of information, called nucleotides," explained co-lead author Philip Awadalla of the University of Montreal's Faculty of Medicine and Director of CARTaGENE. "Three billion come from each parent, and based on indirect evolutionary studies, we had previously estimated that parents would contribute an average of 100-200 mistakes in these pieces of information to their child. Our genetic study, the first of its kind, shows that actually much fewer mistakes or mutations are made." Awadalla published the study with co-author Matt Hurles of the Wellcome Trust Sanger Institute in Nature Genetics on June 12, 2011.

As mutations play a key role in the evolutionary process, geneticists will now revise the number of generations separating us from genetic relatives such as apes. "In principle, evolution is happening a third as slowly as previously thought," Awadalla said. The researchers made the discovery by looking at the complete genomes of two families a mother, father and their child. In another first, the findings enabled the team to determine whether men contribute more mutations to their offspring than women. The theory is that because mistakes are made during cell division and DNA replication, and males produces many millions more gametes (sperm) than women (eggs), more mutations would come from men compared to women. In one of their families, men contributed six times as many genetic errors to their children.

However, the research also showed a wide variation b
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Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

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