Navigation Links
Fail-safe system may lead to cures for inherited disorders
Date:9/15/2011

Scientists at the University of California, San Diego School of Medicine have uncovered a previously unknown fail-safe (compensatory) pathway that potentially protects the brain and other organs from genetic and environmental threats. The discovery could provide new ways to diminish the negative consequences of genetic mutations and environmental toxins that cause neurological diseases and other maladies.

The findings are published in the Sept. 16 issue of the journal Molecular Cell.

Messenger ribonucleic acid (mRNA) is an essential molecule that "reads" genetic information contained within the human genome, and based on this information, generates proteins essential for life. A key inherent feature of mRNA is its "stop signal," which tells cellular machinery to stop reading the mRNA because it has produced a full-length protein. Importantly, in some aberrant mRNAs, the stop signal is displayed too early, resulting in the production of a shorter-than-normal protein. Some of these short proteins can be highly toxic to cells. To avoid their production, cells use a quality control pathway called nonsense-mediated mRNA decay or NMD, which rapidly degrades "bad" mRNAs with early stop signals.

In research published earlier this year, Miles Wilkinson, PhD, professor of reproductive medicine and a member of the UCSD Institute for Genomic Medicine, and colleagues, revealed that NMD is important for the normal development of the brain and the nervous system. Jozef Gecz, PhD, professor of pediatrics at the University of Adelaide, showed that when NMD doesn't work correctly, neurological conditions arise, ranging from mental retardation and attention-deficit disorder to schizophrenia and autism. These conditions are likely due to the production and accumulation of short proteins in the brain.

Like all components of the body, the NMD pathway is vulnerable to insults, such as environmental toxins or gene mutations. "If s
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The battle of the morphogens: How to get ahead in the nervous system
2. Database of water, wastewater pipeline infrastructure systems to be launched Sept. 1
3. Researchers on the trail of a treatment for cancer of the immune system
4. A mold on which to create new parts of the puzzle that is the nervous system
5. National Center for Systems Biology to be established at Medical College
6. Scientists explore the role of aeroecology in bat conservation and ecosystem health
7. Most plant species important in various and varying ecosystems: ISU research
8. Trauma drama: K-State professor researches drama queen of immune system
9. Guam researcher studies Mount Pinatubo ecosystem recovery
10. GTSI Wins Department of Defense Contract to Provide Biometric Automated Toolset Systems for U.S. Army
11. IOF urges systematic osteoporosis management after vertebral fracture augmentation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... Ark. , Feb. 25, 2015  ABC ... and billing in the Health and Fitness Industry, ... well as to MYiCLUBonline.  The latest upgrade includes ... the inclusion of cardless check-in via Identity One ... the first time through interactive displays at the ...
(Date:2/19/2015)... , Feb .19, 2015 Research and ... the addition of the "Military Electro-Optical / ... Sensor Technology, by Platform - Forecast to 2020" ... The military electro-optical/infrared systems market is expected to ... CAGR of 7.71%. This report segments ...
(Date:2/11/2015)... , February 11, 2015 ... research report "Access Control Market by Product (Cards and ... Residential, Military and Defense, Government, Industrial, Healthcare, Education) and ... published by MarketsandMarkets, the Access Control Market ... 2020, growing at a CAGR of 10.6% ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... Just three months of daily, vigorous physical activity in ... risk, researchers say. Studies of about 200 overweight, ... exercise program reduces body fat and improves bone density. ... them into lean, healthy kids? No. They are still ...
... strains seem to be more effective in a semi-urban population ... according to an article in the Journal of Infectious Diseases, ... the Infectious Diseases Society of America. The study is ... from the National Institutes of Health on October 22, 2007 ...
... An international team of researchers led by ... discovered two genes linked to a disabling form ... progressive disease in which some or all of ... validated the association of two genes implicated in ...
Cached Biology News:Exercise improves thinking, reduces diabetes risk in overweight children 2Exercise improves thinking, reduces diabetes risk in overweight children 3Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas 2Study reveals 2 genes linked to disabling arthritis 2Study reveals 2 genes linked to disabling arthritis 3
(Date:3/5/2015)... (PRWEB) March 05, 2015 The next ... have received the CE mark (European) approval. The CE ... Free Trade Association (EFTA) and the European Union. Following ... now been granted to implants supplied by the Turkey-based ... conditions. , Osimplant's Cervical Expandable Bladed HA PEEK ...
(Date:3/4/2015)... 2015 The UPMC Center for Health Security ... the Emerging Leaders in Biosecurity Initiative (ELBI). As part ... field of biosecurity, UPMC has selected 28 US and ... of backgrounds, including biological science, medicine, policy, the military, ... "With the vision and support of the Defense Threat ...
(Date:3/4/2015)... DUBLIN , Mar. 04, 2015 Research ... announced the addition of the "Global Biologics ... their offering. , The Global ... professional and in-depth study on the current state ... The report provides a basic overview of the ...
(Date:3/4/2015)... , March 4, 2015 AcelRx ... specialty pharmaceutical company focused on the development and ... acute and breakthrough pain, today announced that it ... results after market close on Monday, March 9th, ... call at 4:30 p.m. Eastern Time (1:30 p.m. ...
Breaking Biology Technology:Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 2Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 3UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3Global Biologics and Biosimilars Industry Report 2015-2020 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3
... , June 21 Reportlinker.com announces that a ... , , ... Molecular Diagnostics Market: DNA Probes and Biochips -- New Product ... Suppliers , , ...
... June 21 Every nine and a half minutes, someone in the ... these individuals doesn,t know it. To help stem the spread of this disease, the ... will allow patients to be diagnosed earlier than ever before. , ... Abbott,s ARCHITEC T HIV Ag/Ab Combo assay ...
... June 21, 2010 Sosei Group Corporation,("Sosei"; TSE Mothers Index: 4565), announced today that it ... Chiba, Japan . , , , ... as a spin-off from DIC,Corporation (TSE Section 1 Index: 4631). , ... Strategic Rationale , , , ...
Cached Biology Technology:Reportlinker Adds Molecular Diagnostics Market: DNA Probes and Biochips -- New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers 2Reportlinker Adds Molecular Diagnostics Market: DNA Probes and Biochips -- New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers 3Reportlinker Adds Molecular Diagnostics Market: DNA Probes and Biochips -- New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers 4Reportlinker Adds Molecular Diagnostics Market: DNA Probes and Biochips -- New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers 5Reportlinker Adds Molecular Diagnostics Market: DNA Probes and Biochips -- New Product Development Opportunities and Business Expansion Strategies for Instrument and Reagent Suppliers 6FDA Approves First-of-Its-Kind HIV Test Which Can Detect HIV Days Earlier Than Current U.S. Tests 2FDA Approves First-of-Its-Kind HIV Test Which Can Detect HIV Days Earlier Than Current U.S. Tests 3FDA Approves First-of-Its-Kind HIV Test Which Can Detect HIV Days Earlier Than Current U.S. Tests 4FDA Approves First-of-Its-Kind HIV Test Which Can Detect HIV Days Earlier Than Current U.S. Tests 5Sosei to Acquire Activus Pharma 2Sosei to Acquire Activus Pharma 3Sosei to Acquire Activus Pharma 4
...
... DEPC-treated Water is suitable for ... prepared by incubating with 0.1% ... to remove the DEPC.DNase/RNase-Free Distilled ... use in all molecular biology ...
IHC detection kit for BrdU in cells and tissues...
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: