Navigation Links
Factor in naked mole rat's cells enhances protein integrity
Date:8/29/2014

SAN ANTONIO (Aug. 29, 2014) Scientists at the Barshop Institute for Longevity and Aging Studies, part of the School of Medicine at the UT Health Science Center at San Antonio, have found another secret of longevity in the tissues of the longest-lived rodent, the naked mole rat.

They reported that a factor in the cells of naked mole rats protects and alters the activity of the proteasome, a garbage disposer for damaged and obsolete proteins.

The factor also protects proteasome function in human, mouse and yeast cells when challenged with various proteasome poisons, studies showed. These proteasomes usually rapidly stop functioning, leading to the accumulation of damaged proteins that further impair cell function, contributing to the vicious cycle that leads to cell death.

"I think this factor is part of an overall process or mechanism by which naked mole rats maintain their protein quality," study first author Karl Rodriguez, Ph.D., said.

Generally, as an organism ages, not only are there more damaged proteins in need of disposal, but the proteasome itself becomes damaged and less efficient in clearing out the damaged proteins.

As a result, protein quality declines and this contributes to the functional declines seen during aging. Enhancement of protein quality, meanwhile, leads to longer life in yeast, worms, fruit flies and naked mole rats, Dr. Rodriguez said.

Dr. Rodriguez, a San Antonio native who completed both his master's and doctoral degrees at the Health Science Center, is a postdoctoral fellow in the laboratory of Rochelle Buffenstein, Ph.D., professor of physiology at the Barshop Institute. For this study, the Buffenstein lab also collaborated with Pawel Osmulski, Ph.D., assistant professor of molecular medicine; Susan Weintraub, Ph.D., professor of biochemistry; and Maria Gaczynska, Ph.D., associate professor of molecular medicine.

Naked mole rats, which burrow through underground
'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Environmental factors in Tiny Tims near fatal illness
2. Soy-based S-equol supplement reduces metabolic syndrome risk factors
3. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
4. Impaired recovery of Atlantic cod -- forage fish or other factors?
5. Longer sleep times may counteract genetic factors related to weight gain
6. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
7. Time, place and how wood is used are factors in carbon emissions from deforestation
8. SRI Sarnoffs Iris on the Move® N-Glance™ Identification System Receives Lenel Factory Certification
9. Growth factor in stem cells may spur recovery from MS
10. Some factors that impact islet transplantation explored in Cell Transplantation papers
11. Some factors that impact islet transplantation explored in Cell Transplantation papers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Factor in naked mole rat's cells enhances protein integrity
(Date:9/30/2014)... Mediterranean each year, but its deep-blue waters host ... 1,000 alien species, including fish, crustaceans, and algae ... activities. In the open-access journal Frontiers in ... analyzed data from a new information system developed ... introduction of alien species has changed the native ...
(Date:9/30/2014)... watermelon, salmon, and strawberries all have in common? ... of chromosomes and are diploid, these organisms are all ... chromosomesseedless watermelon and salmon have 3 and 4 sets ... this might seem surprising, in fact most plant species ... over a century ago, but only recently, with the ...
(Date:9/30/2014)... Prenatal exposure to tetrachloroethylene (PCE) in drinking water ... abruption, according to a new study led by ... , The study, published in the journal ... 1,019 unexposed pregnancies among 1,766 women in Cape ... late 1960s to the early 1980s by the ...
Breaking Biology News(10 mins):Biodiversity in the Mediterranean is threatened by alien species 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Contaminated water linked to pregnancy complications, BU study finds 2
... an odd-looking mouse discovered through a U.S. government breeding program in ... set of ribs in its neck and nobody knew why. ... of California, San Francisco has now spilled the genetic secrets of ... new wrinkle in the genetic code an entirely unrecognized way ...
... to announce BIOLOGY OPEN (BiO), a new online only, ... of the biological sciences including cell science, developmental biology ... rapid publication for peer reviewed, scientifically sound observations and ... will address some big issues in publishing and is ...
... Two groups of small fish, one from a Caribbean island and ... fastest rates of evolution known in any organism, according to a ... found from Massachusetts to Venezuela -- and they are all pretty ... Davis graduate student working with Peter Wainwright, a professor of evolution ...
Cached Biology News:Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 2Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists 3Announcing BIOLOGY OPEN from the Company of Biologists 2'Explosive' evolution in pupfish 2
(Date:9/30/2014)... AMHERST, Mass. Using a bio-mimicking analog of ... of grass, an international research team led by ... has taken a major step in developing long-sought ... to electricity for use in electronic devices. ... UMass Amherst and others at Stanford University and ...
(Date:9/30/2014)... Shimadzu Scientific Instruments has released the DSES-1000 ... tool for measuring displacement in rubber and other ... movement distance, the DSES-1000 can measure elongations up ... 10 mm. In addition, it achieves +/- 0.2 ... within +/- 100 µm below 50-mm stroke. , ...
(Date:9/30/2014)... Proove Biosciences , the commercial and research leader ... genetic test built upon research from their published P.A.I.N. ... provide physicians with an objective way to understand theirs ... between individuals. With this new test, physicians will be ... predisposition that will affect their pain tolerance. , The ...
(Date:9/30/2014)... CORD:USE Cord Blood Bank – www.corduse.com ... entered into an Equity and Exclusive Services Agreement with ... of patented technologies for the isolation of human cord ... is performing Phase I/II clinical trials in ... using Tianhe,s Stem Cell Educator Therapy showing that the ...
Breaking Biology Technology:Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... Virent , a University of Wisconsin-Madison spinoff working ... from the Department of Energy for continued research. , ,The ... and sugar in a one-step process as part of a ... of the problems of storing hydrogen, a highly explosive gas. ...
... for the 21st Century Act, commonly called Check 21, ... electronic check imaging. , ,Check 21, which will come ... the efficiency of the payments system by legalizing the ... the physical documents. Using the substitute check, banks are ...
... live in interesting times. Not so long ago, we IT practitioners may ... moons on them. What we did was a mystery to the rest ... magic trick gone bad, there was a huge puff of smoke on ... for all the world to see. , ,Somewhere in all of that, ...
Cached Biology Technology:Wisconsin firms make acquisitions for Check 21 readiness 2IT leadership is not just for CIOs anymore 2
... workstation offers precise 96 and 384-well transfers ... 100ul and 200ul disposable tips, the 96 ... and precision across a volume range from ... two positions that enable indexing into 384 ...
... Rabbit Tissue Arrays contain 60 rabbit tissue samples ... contains 4 unstained slides and 1 hematoxylin and ... slide contains 15 different tissues from 4 rabbit ... per slide. Each tissue sample (or core) is ...
A univariate (peak height or area) quantitative multi-component analysis package....
... The new, upgraded micro 10 represents ... that brings many of the benefits of ... of the small benchtop dispenser. Dispensing accurate ... well, the micro 10 has unique advantages ...
Biology Products: