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Factor in keeping 'good order' of genes discovered
Date:10/3/2011

expressing the mutant lamin, they detected abnormal retention of a muscle-specific gene array at the nuclear periphery. (The effect of the mutation was specific to muscle and had no effect on other cells.) The animals expressing the mutant lamin had selectively perturbed structure of body muscle and reduced muscle function, which resemble the situation in human patients.

One important conclusion of this study, which appears in the latest online edition of the journal Current Biology, is that lamin filaments help arrange silent genes at the nuclear periphery and during normal tissue-specific activation -- allow release of the activated normal gene.

Another conclusion is that a disease-linked local mutation in lamin can impair muscle-specific reorganization of genes during tissue-specific promoter activation in a dominant manner. This dominance and the correlated muscle dysfunction typifies, for example, Emery Dreifuss Muscular Dystrophy.


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Contact: Jerry Barach
972-258-82904
The Hebrew University of Jerusalem
Source:Eurekalert  

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