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FSU researcher using computers to hone cancer-fighting strategies
Date:7/2/2008

imal number of cancer cells.

*The rate at which immunotoxins bind with malignant cells and the relative amount of antigens expressed on the cell surface are especially critical factors, because an imbalance in those two factors may result in over-bombardment of a single cancer cell with excessive numbers of immunotoxins, leaving many other cancer cells unharmed. The opposite scenario also is possible: If not enough immunotoxins bind with malignant cells, too few cells will be killed with each dose.

"Because the level of anticancer drug doses that can be given to any patient is limited by immunogenicity -- the immune response that results -- it is essential to explore how the efficacy of recombinant immunotoxins can be enhanced without resorting to escalating doses," Chen said. "Our computational research has enabled us to quantify and develop models describing many of the factors that influence immunotoxins' behavior in the body. This is essential knowledge that cancer researchers and doctors must have in order to take the next steps forward in developing immunotoxin drugs that might one day be approved as a standard treatment for cancer patients."


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Contact: Kevin C. Chen
kevinchen@eng.fsu.edu
850-410-6684
Florida State University
Source:Eurekalert  

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