Navigation Links
FSU researcher using computers to hone cancer-fighting strategies
Date:7/2/2008

TALLAHASSEE, Fla. -- A Florida State University faculty member who uses computational techniques to evaluate a new class of cancer-killing drugs is attracting worldwide attention from other researchers.

Kevin C. Chen, an assistant professor of chemical and biomedical engineering at the Florida A&M University-Florida State University College of Engineering, is using high-powered computers to determine how substances known as recombinant immunotoxins can best be modified in order to attack and kill malignant tumors while doing minimal harm to a patient's healthy cells.

"Cancer is a disease of tremendous complexity, so the analysis and interpretation of data demands sophisticated, specialized computational methods," Chen said of his research.

Recombinant immunotoxins, Chen explained, are new drugs that are being tested in clinical trials for certain types of cancer therapy. They consist of tiny fragments of antibody proteins that are fused at the genetic level to toxins produced by certain types of bacteria, fungi or plants.

"Once injected into the body, the antibody portion of the immunotoxin targets specific proteins, called antigens, that are massively expressed on the surface of cancer cells," Chen said. "These cells are subsequently killed by the accompanying toxins. Normal, healthy cells, meanwhile, are not recognized and thus are spared."

That is the theory, at least. In practice, Chen acknowledges that numerous factors can decrease the immunotoxins' effectiveness. Among them:

*The large size of some immunotoxin molecules can hinder their ability to move to the targeted location to bind readily with cancer cell proteins, leading to efforts to reduce their size.

*The immunotoxin molecules' stability in the bloodstream and in the extracellular matrix can affect their length of time in circulation and in tumor tissues, respectively, thereby determining their effectiveness at killing the opt
'/>"/>

Contact: Kevin C. Chen
kevinchen@eng.fsu.edu
850-410-6684
Florida State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Texas A&M researchers develop tool to study complex clusters of genes
2. Weekends slow weight loss, researchers find
3. Researchers coat titanium with polymer to improve integration of joint replacements
4. Researchers link early stem cell mutation to autism
5. Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohns disease study
6. Salk researchers reprogram adult stem cells in their natural environment
7. UIC researchers make promising finding in severe lung disease
8. Montana State researchers release guide to noninvasive carnivore research
9. Growth hormones link to starvation may be clue to increasing life span, researchers find
10. Researchers explain nitrogen paradox in forests
11. UC Davis researcher leads climate-change discovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
FSU researcher using computers to hone cancer-fighting strategies
(Date:2/24/2015)... 2015 This report analyzes the worldwide markets for Face ... Biometrics, and Voice Biometrics. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific , ... , and Latin America . Annual estimates and ... seven-year historic analysis is provided for these markets. Market data and ...
(Date:2/19/2015)... Feb .19, 2015 Research and Markets ... of the "Military Electro-Optical / Infrared Systems ... by Platform - Forecast to 2020" report ... electro-optical/infrared systems market is expected to reach $16.35 ... 7.71%. This report segments the military ...
(Date:2/12/2015)... , Feb. 12, 2015   MedNet Solutions ... in clinical study management systems, has recently bolstered ... further distinguishing iMedNet as ... Organizations (CROs) and healthcare consultants.  Building on the ... customer referrals and numerous co-marketing opportunities), MedNet,s new ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2
... is uniquely a "dual" sense, in that the brain perceives ... nose rather than the mouth. In the August 18, 2005, ... of chocolate activated different brain regions according to whether the ... or through the nose. , In a joint research effort ...
... cancer melanoma, studying functional tissue rather than cell ... development, according to new research from a Howard ... School of Medicine. , Though multiple genetic alterations ... been able to establish a direct causal link ...
... a small molecule of RNA called microRNA ?a chemical cousin ... protein involved in the early development of heart muscle. , ... Nature, may aid scientists in their understanding of how a ... cell, as well as offer researchers a way to predict ...
Cached Biology News:Nose odors and mouth odors: The brain distinguishes 2Nose odors and mouth odors: The brain distinguishes 3Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack 2Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack 3MicroRNA tweaks protein that controls early heart development 2MicroRNA tweaks protein that controls early heart development 3
(Date:3/3/2015)... SAN DIEGO , March 3, 2015  Halozyme Therapeutics, ... the Barclays 2015 Global Healthcare Conference in Miami, ... ET/10:05 a.m. PT. David A. Ramsay , Chief Financial ... will be webcast through the "Investors" section of Halozyme,s corporate ... made available for 90 days following the event. To access ...
(Date:3/3/2015)... LEXINGTON, Ky. (PRWEB) March 03, 2015 ... aligning their schedules for one event: the Alltech REBELation ... USA, from May 17-20. Now in its 31st year, ... people from 70 countries, and the opportunity to join ... week, March 7 at 11:59 p.m. EST, at which ...
(Date:3/3/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rcv4lq/gene_therapy ... Therapy Market, 2015 - 2025" report to their ... report provides an extensive study on the marketed and ... carried out in this field for over a decade ... in Asian markets; one approved in the EU). There ...
(Date:3/3/2015)... March 3, 2015 /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), ... technologies and products for advanced microarray diagnostics, today ... CFE  to its Management team. In his capacity ... its transition from a development stage to a ... advance the Company,s capital market strategy and to ...
Breaking Biology Technology:Halozyme Therapeutics To Present At The Barclays 2015 Global Healthcare Conference 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3
... Sosei Group Corporation,("Sosei"; TSE Mothers Index: 4565), ... its wholly owned Japanese subsidiary, has,entered into a ... ("ASKA", TSE First Section Index: 4514) for the ... NorLevo(R) is an oral emergency contraceptive "morning after ...
... as bioethanol is to make a major contribution to our ... some tiny insect helpers, says Michael Scharf, an assistant professor ... In a review to be published in Biofuels, Bioproducts ... how the enzymes produced by both termites and the micro-organisms ...
... SAN DIEGO, Oct. 21 Cadence Pharmaceuticals,Inc. (Nasdaq: ... in-licensing,developing and commercializing proprietary product candidates principally,for use ... company,s,President and CEO Theodore Schroeder will present the ... 9:30am Pacific Time (12:30pm,Eastern Time) during the BIOCOM ...
Cached Biology Technology:Sosei Agrees Terms With ASKA for Commercialisation of SOH-075 (NorLevo(R)) 2Digesting the termite digestome -- a way to make biofuels? 2Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at the BIOCOM Investor Conference 2
MpV17 transgene, murine homolog, glomerulosclerosis...
GEL FILTRATION CAL KIT HMW, 1 EA. *Category: Gel Filtration Gels....
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and ...
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
Biology Products: