Navigation Links
FSU researcher using computers to hone cancer-fighting strategies
Date:7/2/2008

TALLAHASSEE, Fla. -- A Florida State University faculty member who uses computational techniques to evaluate a new class of cancer-killing drugs is attracting worldwide attention from other researchers.

Kevin C. Chen, an assistant professor of chemical and biomedical engineering at the Florida A&M University-Florida State University College of Engineering, is using high-powered computers to determine how substances known as recombinant immunotoxins can best be modified in order to attack and kill malignant tumors while doing minimal harm to a patient's healthy cells.

"Cancer is a disease of tremendous complexity, so the analysis and interpretation of data demands sophisticated, specialized computational methods," Chen said of his research.

Recombinant immunotoxins, Chen explained, are new drugs that are being tested in clinical trials for certain types of cancer therapy. They consist of tiny fragments of antibody proteins that are fused at the genetic level to toxins produced by certain types of bacteria, fungi or plants.

"Once injected into the body, the antibody portion of the immunotoxin targets specific proteins, called antigens, that are massively expressed on the surface of cancer cells," Chen said. "These cells are subsequently killed by the accompanying toxins. Normal, healthy cells, meanwhile, are not recognized and thus are spared."

That is the theory, at least. In practice, Chen acknowledges that numerous factors can decrease the immunotoxins' effectiveness. Among them:

*The large size of some immunotoxin molecules can hinder their ability to move to the targeted location to bind readily with cancer cell proteins, leading to efforts to reduce their size.

*The immunotoxin molecules' stability in the bloodstream and in the extracellular matrix can affect their length of time in circulation and in tumor tissues, respectively, thereby determining their effectiveness at killing the opt
'/>"/>

Contact: Kevin C. Chen
kevinchen@eng.fsu.edu
850-410-6684
Florida State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Texas A&M researchers develop tool to study complex clusters of genes
2. Weekends slow weight loss, researchers find
3. Researchers coat titanium with polymer to improve integration of joint replacements
4. Researchers link early stem cell mutation to autism
5. Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohns disease study
6. Salk researchers reprogram adult stem cells in their natural environment
7. UIC researchers make promising finding in severe lung disease
8. Montana State researchers release guide to noninvasive carnivore research
9. Growth hormones link to starvation may be clue to increasing life span, researchers find
10. Researchers explain nitrogen paradox in forests
11. UC Davis researcher leads climate-change discovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
FSU researcher using computers to hone cancer-fighting strategies
(Date:4/17/2014)... April 17, 2014The development of stem cell therapies to ... to characterize stem cell populations based on cell surface ... a new marker that is highly expressed in a ... blood, which they describe in an article in ... Ann Liebert, Inc., publishers. The article is available free ...
(Date:4/17/2014)... N.M. A credit-card-sized anthrax detection cartridge developed at ... business makes testing safer, easier, faster and cheaper. ... anthrax, is commonly found in soils all over the ... in both humans and animals. The bacteria can survive ... B. anthracis may occur through skin contact, ...
(Date:4/17/2014)... bone marrow need to produce hydrogen sulfide in order ... a new study from the Center for Craniofacial Molecular ... USC. , Professor Songtao Shi, principal investigator on the ... the cells governs the flow of calcium ions. The ... results in osteogenesis, or the creation of new bone ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... progress on their guarantee to protect global oceans from overfishing ... 15th June) in Science , the Zoological Society of ... by governments to protect the world,s oceans and shown that ... At the World Summit on Sustainable Development in ...
... A grasshopper,s change in diet to high-energy carbohydrates while ... releases carbon dioxide into the atmosphere, according to research ... . Grasshoppers like to munch on nitrogen-rich grass ... when spiders enter the picture, grasshoppers cope with the ...
... found a surprising connection between a key DNA-repair process and ... and other chronic conditions. The discovery promises to open up ... could ultimately yield novel treatments for a wide variety of ... it goes against current dogma about the role of DNA ...
Cached Biology News:A sea of broken promises 2Predators have outsized influence over habitats 2Scientists tie DNA repair to key cell signaling network 2
(Date:1/15/2014)... is the device," Nobel laureate Herbert Kroemer famously ... found at the junctures where layers of different ... the interfaces between layers of metal oxides are ... favorites as spintronics, high-temperature superconductors, ferroelectrics and multiferroics. ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Look inside ... hard-working items for the lab, from fluid handling to ... (GIS)—ready to ship when you order. , Preferred ... Pumps , from the L/S® model for precise flow ...
(Date:1/15/2014)... 15, 2014 This webinar will focus ... clinical safety assessment in biosimilars. , Regulatory frameworks are ... drug development, however the complex nature of biopharmaceuticals makes ... and efficacy extremely challenging. Based on the specific aspects ...
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
Breaking Biology Technology:A deeper look at interfaces 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... CV Therapeutics,Inc. (Nasdaq: CVTX ) announced ... the Company issued new inducement stock options to,19 ... in,connection with its commercialization efforts in the United ... aggregate 119,200 shares of,common stock and are classified ...
... SectorWatch.biz announces the,availability of MarketStats on public ... today., Investors can view all of SectorWatch.biz ... -- Click on MarketStats, Today,s MarketStats on ... (OTC Bulletin Board: CVBT), Boston,Scientific Corp. (NYSE: ...
... - Atrium Innovations Inc.,(TSX: ATB) will hold its ... time on February 29, 2008. The call will ... and full year results issued earlier that,day. Participants ... numbers:,416-644-3420, 514-807-8791 or 800-731-5774 or via the Company,s ...
Cached Biology Technology:CV Therapeutics Reports Option Grants Under Nasdaq Marketplace Rule 4350 2SectorWatch.biz Issues MarketStats on CVBT, BSX, MDT, CXM and DNA 2Atrium Innovations to Hold 2007 Fourth Quarter and Full-Year Financial Results Conference Call and Webcast on February 29 2
... use spatulas have been designed to save ... for those interested in eliminating the recycling ... spatula is individually packaged, RNase/DNase free, non-pyrogenic ... a new product number, created to easily ...
... cytopathic effect inhibition assays, also known as ... assay measures the antibody's ability to neutralize ... types include; tissue culture supernatents; serum and ... unit is defined as the quantity of ...
... Yeast nitrogen base (YNB) is a base ... yeast media. YNB contains ammonium sulfate but does ... single-use pouches are available. Each pouch contains ... for Pichia media or 1000 ml of 10X ...
... Stem Cell Identification Kit. ... a substrate for the ... that is highly expressed ... cells, making ALDH an ...
Biology Products: