Navigation Links
FSU researcher using computers to hone cancer-fighting strategies
Date:7/2/2008

TALLAHASSEE, Fla. -- A Florida State University faculty member who uses computational techniques to evaluate a new class of cancer-killing drugs is attracting worldwide attention from other researchers.

Kevin C. Chen, an assistant professor of chemical and biomedical engineering at the Florida A&M University-Florida State University College of Engineering, is using high-powered computers to determine how substances known as recombinant immunotoxins can best be modified in order to attack and kill malignant tumors while doing minimal harm to a patient's healthy cells.

"Cancer is a disease of tremendous complexity, so the analysis and interpretation of data demands sophisticated, specialized computational methods," Chen said of his research.

Recombinant immunotoxins, Chen explained, are new drugs that are being tested in clinical trials for certain types of cancer therapy. They consist of tiny fragments of antibody proteins that are fused at the genetic level to toxins produced by certain types of bacteria, fungi or plants.

"Once injected into the body, the antibody portion of the immunotoxin targets specific proteins, called antigens, that are massively expressed on the surface of cancer cells," Chen said. "These cells are subsequently killed by the accompanying toxins. Normal, healthy cells, meanwhile, are not recognized and thus are spared."

That is the theory, at least. In practice, Chen acknowledges that numerous factors can decrease the immunotoxins' effectiveness. Among them:

*The large size of some immunotoxin molecules can hinder their ability to move to the targeted location to bind readily with cancer cell proteins, leading to efforts to reduce their size.

*The immunotoxin molecules' stability in the bloodstream and in the extracellular matrix can affect their length of time in circulation and in tumor tissues, respectively, thereby determining their effectiveness at killing the opt
'/>"/>

Contact: Kevin C. Chen
kevinchen@eng.fsu.edu
850-410-6684
Florida State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Texas A&M researchers develop tool to study complex clusters of genes
2. Weekends slow weight loss, researchers find
3. Researchers coat titanium with polymer to improve integration of joint replacements
4. Researchers link early stem cell mutation to autism
5. Montreal Heart Institute and Mount Sinai Hospital researchers contribute to Crohns disease study
6. Salk researchers reprogram adult stem cells in their natural environment
7. UIC researchers make promising finding in severe lung disease
8. Montana State researchers release guide to noninvasive carnivore research
9. Growth hormones link to starvation may be clue to increasing life span, researchers find
10. Researchers explain nitrogen paradox in forests
11. UC Davis researcher leads climate-change discovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
FSU researcher using computers to hone cancer-fighting strategies
(Date:7/29/2014)... the first to show that while the impact of ... negative effects may be reduced by maintaining a healthy ... participants who exercised, slept well and ate well had ... healthy lifestyles, even when they had similar levels of ... in the department of psychiatry at UCSF. "It,s very ...
(Date:7/28/2014)... the United States have a circulatory problem of the ... and may even require surgery in serious cases. This ... in turn, limb amputation. , At The University of ... scientists tested a non-surgical preventative treatment in a mouse ... increased blood circulation. Their proof-of-concept study appears in ...
(Date:7/28/2014)... The genome of Solanum pennellii , a wild ... an international group of researchers including the labs headed ... UC Davis Department of Plant Biology. The new genome ... , The work, published July 27 in the journal ... and colleagues at Aachen University in Germany. The UC ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2
... farmers who grow genetically engineered (GE) crops are realizing ... production costs, fewer pest problems, reduced use of pesticides, ... a new report from the National Research Council. ... a main component in Roundup and other commercial weed ...
... levels in crop lands is a key factor that ... according to a paper published in the International ... Current global issues include carbon footprints, water resources and ... growth is often overlooked in the global context. ...
... WASHINGTON, D.C. Scientific breakthroughs in molecular targeting, translational cancer ... than 17,000 scientists from around the world gather at the ... 101st Annual Meeting 2010. "We are now entering ... will have the ability to control this disease in the ...
Cached Biology News:Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective 2Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective 3Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective 4Calculating agriculture's phosphorus footprint 2American Association for Cancer Research hosts 101st Annual Meeting 2010 in Washington, D.C. 2
(Date:7/29/2014)...   Sequenom, Inc. (NASDAQ: SQNM ... analysis solutions, and Mayo Medical Laboratories (MML), ... the United States , have announced a ... "We have great appreciation for Mayo Clinic,s ... welcome the opportunity to partner with the organization,s leading ...
(Date:7/29/2014)... Tough, ultralight foam of atom-thick sheets can be made ... invented at Rice University. , In microscopic images, ... with floors and walls that reinforce each other. The ... and walls of graphene oxide that self-assemble with the ... researchers say the foam could find use in structural ...
(Date:7/29/2014)... 29, 2014  Pomerantz LLP is investigating claims on ... the "Company") (NASDAQ: IPXL).  Such investors are advised to ... or 888-476-6529, ext. 237. The investigation ... directors have violated Sections 10(b) and 20(a) of the ... July 29, 2014, Impax Laboratories, Inc. (the "Company") issued ...
(Date:7/29/2014)... Pa. , July 29, 2014  Discovery ... dedicated to advancing a new standard of respiratory ... results on August 5, 2014 before the open ... The Company will host a live teleconference and ... During the conference call, Discovery Labs, management will ...
Breaking Biology Technology:Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4Tough foam from tiny sheets 2SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Impax Laboratories, Inc. - IPXL 2Discovery Labs to Report 2014 Second Quarter Financial Results and Hold Conference Call on Tuesday, August 5, 2014 at 9:00 a.m. Eastern Time 2
... Dec. 21, 2011  BioStorage Technologies, a global provider of ... logistics for the bioscience industry, is pleased to announce ... fundraising campaign to the Susan G. Komen for the ... Cancer Center. The $1,000 donation was presented to the ...
... 2011 Neogen Corporation (NASDAQ: NEOG ) announces ... Results Webcast When:  Thursday, December 22, 2011 @ ... How:  Live over the Internet -- Simply log ... Contact:  Terry Maynard of Neogen Corporation, +1-800-234-5333. ...
... 21, 2011 Acumen Pharmaceuticals announces today the ... Merck & Co., Inc.) of a 2003 agreement, ... exclusive worldwide rights to develop and commercialize anti-ADDL ... Merck,s decision to discontinue this anti-ADDL ...
Cached Biology Technology:BioStorage Technologies Partners with Susan G. Komen for the Cure Tissue Bank at IU Simon Cancer Center to Raise Money and Awareness for Breast Cancer Research 2BioStorage Technologies Partners with Susan G. Komen for the Cure Tissue Bank at IU Simon Cancer Center to Raise Money and Awareness for Breast Cancer Research 3Acumen Pharmaceuticals Regains Worldwide Rights to Anti-ADDL Antibody Therapeutics and Diagnostics for Alzheimer's Disease From Merck 2
... pump series combines Harvard Apparatuss best pump mechanism, ... wide range of configuration options. A lookup table ... syringes from all the major manufacturers. A bright, ... pertinent information from across the lab. All models ...
... This CLS number is a new product ... number. If showing no availability yet, please ... or contact customer service for assistance. ... Comp Dim: surface area 21 cm 2 ...
... ultimate tool for investigating dynamic events in ... have been limited at wavelengths longer than ... transmit in the deep UV. HORIBA Jobin ... a filter-based confocal system (the DynaMic) to ...
... protein crystallography involves using many of the ... The liquid handling requirements are similar to ... crystallography plates have 24 or 48 wells ... For higher throughput, the number of wells ...
Biology Products: