Navigation Links
FDA funds pediatric trial testing genetically reprogrammed HSV to treat cancer
Date:10/12/2010

to attack cancer cells in other ways such as activating certain types of chemotherapies in a one-two punch or destroying blood vessels that feed tumors. Research in mouse models of human cancer by Cripe's laboratory has shown oncolytic HSV agents to be effective at shrinking a variety of modeled tumor types, suggesting a possible approach for treating human disease.

"Our goal in the current HSV1716 trial is to light a fire to the cancer so that the virus replicates and spreads to the cancer cells," Dr. Cripe explained. "We have to take this one step at a time and the initial phase of the trial focuses on making sure the virus doesn't cause adverse side effects. It has been tested in Europe in adults with brain cancer, squamous cell carcinoma and melanoma and shown in those trials to be safe."

HSV1716 has also been tested extensively for safety in animal models at Cincinnati Children's Hospital by Dr. Cripe and in Europe prior to it being tested in people.

The Phase I trial will include up to 18 patients and is expected to last three years. The optimum safe dosing for this virus is unknown, so the study will sequentially increase dosing levels in small groups of patients and observe for side effects as the trial proceeds. This earliest phase tests the lowest dose on older children and young adults with solid tumor cancers who have limited or no standard therapy options available.

The researchers plan to add younger patients with earlier stages of cancer as the trial proceeds. They will not be able to determine if the safety trial is successful until all patients have received treatment and the results analyzed. As with all clinical trials of new anticancer therapies in patients, many factors can influence the risk for severe side effects and anticancer activity. Even though HSV1716 may cause tumor shrinkage in mouse models of pediatric cancer, it may not have antitumor effect in patients.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. NIH funds Center of Excellence for Molecular Hematology at Cincinnati Childrens
2. $1.5M grant funds research aimed at reducing strokes in children with sickle cell disease
3. NIH funds center at Arizona State to battle infectious diseases
4. French national research agency funds PREDIMOL project
5. NHGRI funds development of third generation DNA sequencing technologies
6. $22.5 million grant funds international study of membrane proteins
7. NSF funds innovative approach to biomimetic nanofiber bone regeneration
8. Gulf oil spill: NSF funds research on impacts to Florida Everglades
9. NSF funds Virginia Tech program to train researchers at intersection of engineering, biology
10. NIH funds multicenter glue grant to study enzyme function
11. California funds UCI basic research on stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... While previous studies have shown that marine noise can ... scientists from the Universities of Bristol and Exeter and ... France have demonstrated that boat noise stops embryonic development ... hares, (specifically the sea slug Stylocheilus striatus ... to swim away and later feed on toxic alga ...
(Date:7/30/2014)... Lewis Carroll,s Through the Looking Glass, collaborators from ... Singapore improved a 35-year-old ecology model to better ... of years. , The new model, called a ... Queen Effect," an evolutionary hypothesis introduced by Lee ... organisms must constantly increase their fitness (or ability ...
(Date:7/30/2014)... Everybody knows the shortest distance between two points is ... that sperm have been taking the familiar axiom to ... usually thought to be intense, with each racing for ... in some species, sperm form cooperative groups that allow ... , A new study, conducted by Heidi Fisher, ...
Breaking Biology News(10 mins):Boat noise impacts development and survival of sea hares 2Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3When cooperation counts 2When cooperation counts 3
... USA - Geology doesn,t stop at borders. Mexico, the ... face similar environmental and resource problems. In an effort ... countries, the Center of Geoscience and the Institute of ... Nacional Autnoma de Mxico; UNAM) are hosting the 108th ...
... use comes from wells drilled using polycrystalline diamond compact ... lower the cost of geothermal drilling. Sandia and the ... geothermal drillers might use the original PDC technology, incorporating ... industry. Sandia and the Navy,s Geothermal Program Office ...
... are accumulations of fluid into the intra- or extracellular ... several factors such as stroke or head trauma, among ... neurology. While in other organs swelling does not lead ... to coma and death. Although there are therapeutic solutions ...
Cached Biology News:Geological Society of America Cordilleran section meets in the heart of Mexico 2Geological Society of America Cordilleran section meets in the heart of Mexico 3Geological Society of America Cordilleran section meets in the heart of Mexico 4Polycrystalline diamond drill bits open up options for geothermal energy 2Polycrystalline diamond drill bits open up options for geothermal energy 3Polycrystalline diamond drill bits open up options for geothermal energy 4Step forward in research into new treatments for brain edema 2
(Date:7/31/2014)... Alan Turing, the British mathematician (1912-1954), is famous for ... the 20th century. In 1936 he published a paper, ... first formal concept of a computer algorithm. He next ... designing the machines which cracked the German military codes, ... crucial battles. And in the late 1940,s he turned ...
(Date:7/31/2014)... 2014 The SNIS Foundation recognized its ... fund a translational research project.  The first award ... was presented at the Society of NeuroInterventional Surgery ... Colorado Springs, CO. ... neurovascular conditions, SNIS formed the SNIS Foundation, in ...
(Date:7/31/2014)... July 31, 2014 North Shore Towers, a ... partnered with GI Energy, one of the nation’s leading combined ... million upgrade of its 43-year-old CHP system. The original CHP ... an effort to extend the life of the plant, GI ... associated electrical and heat recovery equipment, while maintaining continuous operation ...
(Date:7/31/2014)... Senomyx , Inc. (NASDAQ: ... taste science technologies to discover, develop, and commercialize ... ingredient supply industries, today reported financial results for ... second quarter with $33.6 million in cash and ... past quarter Senomyx achieved another important milestone with ...
Breaking Biology Technology:A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3North Shore Towers Partners with GI Energy to Install Turnkey Natural Gas-Fired Combined Heat and Power Plant 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16
... NEW YORK, Sept. 9 Future Pharmaceuticals ... General Manager of Informatics at Thermo Fisher Scientific, and Thor-Gunnar ... and Biobank, about data integration: the benefits of data, instrument ... , , "One of the ...
... , , WATERTOWN, Mass., Sept. 9 ... as senior vice president and chief financial officer. DiPalma ... analysis, accounting and operations. , , "EnVivo ... CFO position to help better manage our broad pipeline and ...
... , PRINCETON, N.J., Sept. 9 ... development services to innovative pharmaceutical, biotechnology, generic drug and ... paid down its Convertible Senior Notes that were due ... used for general corporate purposes. , , ...
Cached Biology Technology:Don't Wait to Innovate: Future Pharmaceuticals Magazine Releases Its Issue on Innovation in IT, Cell-Based Therapy and Supply Chains 2EnVivo Pharmaceuticals Names Stephen DiPalma Chief Financial Officer 2PharmaNet Development Group Provides Financial Update and Announces Geographic Expansion 2