Navigation Links
FDA-approved drug restores hair in patients with Alopecia Areata
Date:8/17/2014

udy of more than 1,000 patients with the disease. That study suggested that a "danger signal" in the hair follicles of patientsnot previously linked to alopecia areataattracts the immune cells to the follicle and sparks the attack.

The current paper describes how the team first studied mice with the disease, then tracked backward from the danger signal to identify the specific set of T cells responsible for attacking the hair follicles. Further investigation of mouse and patient cells revealed how the T cells are instructed to attack and identified several key immune pathways that could be targeted by a new class of drugs, known as JAK inhibitors.

Two FDA-approved JAK inhibitors tested separately by the researchersruxolitinib and tofacitinibwere able to block these immune pathways and stop the attack on the hair follicles. In mice with extensive hair loss from the disease, both drugs completely restored the animals' hair within 12 weeks. Each drug's effect was also long-lasting, as the new hair persisted for several months after stopping treatment.

Together with Julian Mackay-Wiggan, MD, MS, director of the Clinical Research Unit in the Department of Dermatology at CUMC and a practicing dermatologist at NewYork-Presbyterian/Columbia who treats patients with multiple types of hair loss, the researchers rapidly initiated a small open-label clinical trial of ruxolitinibwhich is FDA approved for the treatment of a blood disorderin patients with moderate-to-severe alopecia areata (with more than 30 percent hair loss). In three of the trial's early participants, ruxolitinib completely restored hair growth within four to five months of starting treatment, and the attacking T cells disappeared from the scalp.

"We still need to do more testing to establish that ruxolitinib should be used in alopecia areata, but this is exciting news for patients and their physicians," Dr. Clynes said. "This disease has been completely understudiedunti
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Drug design success propels efforts to fight HIV with a combination of 2 FDA-approved drugs
2. Promising compound restores memory loss and reverses symptoms of Alzheimers
3. The nose knows: Gene therapy restores sense of smell in mice
4. Gene network restores CF protein function
5. NSAIDs benefit overweight breast cancer patients, study finds
6. Many older emergency department patients are malnourished
7. Discovery of new form of dystrophin protein could lead to therapy for some DMD patients
8. Patients with autism spectrum disorder are not sensitive to being imitated
9. Patients with hypoventilation may need supplemental oxygen on-board flights
10. Acupuncture at Waiguan improves activation of functional brain areas of stroke patients
11. Test increases odds of correct surgery for thyroid cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
FDA-approved drug restores hair in patients with Alopecia Areata
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... , November 18, 2014 ... Systems Market by Systems (Video, RFID, Access Control, Intrusion ... Factories, Hotels, Banks, Government), Component Service Geography - Global ... Systems Market is projected to be around $25 Billion ... by 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... development of the mammalian brain, the cerebral cortex undergoes ... which is accommodated by folding of the tissue in ... Researchers have now identified a key regulator of this ... are devoted to the performance of specific tasks. This ...
... has won a grant from the Melanoma Research Alliance ... for patients with the disease., Navin Varadarajan, an assistant ... Rahr-MRA Young Investigator Award. The grant gives him $225,000 ... helped melanoma patients who aren,t responding to any other ...
... Amsterdam, The Netherlands, Friday 26 April 2013: New data ... Liver Congress 2013 demonstrate substantial improvements in the detection ... diagnostic urine tests. HCC is common throughout the ... of chronic viral hepatitis or cirrhosis of any cause. ...
Cached Biology News:Developmental neurobiology: How the brain folds to fit 2University of Houston engineering professor awarded grant to study melanoma treatment 2University of Houston engineering professor awarded grant to study melanoma treatment 3Novel screening tests for liver cancer 2Novel screening tests for liver cancer 3
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
(Date:12/22/2014)... & Brussels (PRWEB) December 22, 2014 ... (CfPIE), the global leader of technical training across the ... for Clinical Data Management (SCDM) to provide the ... certification programs —providing access to the more than ... extends SCDM members with 10% off when registering for ...
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that its ... M1 in raw commingled milk is the first lateral ... peer reviewed report of the validation by Technology and ... Fisheries Research (ILVO-T&V) has been published by the Taylor ... toxic aflatoxin and a known carcinogen, can be passed ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... breakthrough on Alzheimer's disease, UW-Madison researcher Jeff Johnson has ... drug. , ,Johnson and fellow researcher Thor Stein led ... asking a simple question: Why don't mouse neurons die ... kill human neurons in early onset Alzheimer's patients? From ...
... business attire these days, it seems hard to imagine that ... , ,(In the spirit of full disclosure, I have to ... other way while a software engineering manager at Digital ... of a construction crew working at our building.) , ,If ...
... and gone, the University of Wisconsin-Madison still has ... Fluffy Bunnies , a team of three computer programming students ... 3 to 7 to compete in the world finals of ... . The team entered the finals by taking first place ...
Cached Biology Technology:Madison-based Mithridion seeks to capitalize on Alzheimer's breakthrough 2Madison-based Mithridion seeks to capitalize on Alzheimer's breakthrough 3Madison-based Mithridion seeks to capitalize on Alzheimer's breakthrough 4Dressing information technology in business clothes 2Dressing information technology in business clothes 3'Fluffy Bunnies' ready for Shanghai programming competition 2'Fluffy Bunnies' ready for Shanghai programming competition 3
Goat polyclonal to Centaurin alpha 2**...
Mouse Anti-Human Killer Cell Immunoglobulin-like Receptor, Two Domains, Long Cytoplasmic Tail, 2 (KIR2DL2 (KIR2DL3 Monoclonal Antibody Family: Immunoglobulin Sub-Family: not assigned-Immunogl...
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Recognizes a full-length CLC-2 voltage-gated Cl- protein and not with other known proteins tested so far....
Biology Products: