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FASEB SRC announces conference: Matricellular Proteins in Development, Health, and Disease
Date:2/4/2013

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Matricellular Proteins in Development, Health, and Disease.

Interactions between cells and their surrounding extracellular matrix (ECM) are the basis for multi-cellular life and essential for cell and tissue organization in all metazoan organisms. Structural ECM components such as collagens, fibronectin, and laminins, are secreted by cells and assembled extracellularly into organized sheets (basement membranes) or three-dimensional fibrils and networks (connective tissue matrix). ECM also contains less abundant, but highly regulated, components that play important roles in controlling cell behavior and matrix remodeling. Because of their distinctive localizations and functional attributes in the ECM, these proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, osteopontin, periostin, fibulin, and SPARC families.

The purpose of this conference is to focus on these matricellular proteins and to examine their structure-function relationships and their impact on signaling networks that play key roles in disease, homeostasis, repair, and development. The conference format includes lectures and poster sessions and short talks selected from submitted abstracts and late breaking work. The program covers both mechanistic scientific perspectives (Sessions 1-3) and disease specific emphases (Sessions 4-9). Mechanistic sessions will discuss novel regulatory mechanisms of the matricellular proteins and their receptors (Session 1) and the complex roles of matricellular proteins in regulation of multiple growth factors in disease (Session 3), which is an important function of these proteins in homeostasis and disease.

For the first time, we will have a session to highlight mammalian and non-mammalian model systems (Session 2). The lo
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Contact: Robin Crawford
src@faseb.org
301-634-7010
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

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