Navigation Links
FANTOM findings boost for biologists
Date:4/20/2009

Genomic regulatory blocks have unique features that may explain their ability to respond to regulatory inputs from very long distances, according to a special thematic series of companion articles from the FANTOM4 consortium. This research, to be published across a number of BioMed Central's open access journals, including Genome Biology and BMC Bioinformatics, provide further insight into HCNE (highly conserved non-coding element) mediated long-range gene regulation at the core of animal multicellularity regulation.

Now at its fourth stage, FANTOM4, prominently led by OSC's Yoshihide Hayashizaki, has culminated after over three years of research. The center joined forces with scientists from research centers and universities in Australia, Switzerland, Norway, South Africa, Sweden, Canada, Denmark, Italy, Germany, Singapore, UK and the United States to publish three milestone papers in the journal Nature Genetics, along side the companion articles in BioMed Central, that challenge current notions of how genes are controlled in mammals.

In one Genome Biology article, researchers have created a novel database and set of interfaces to interpret biological networks and compare large high-throughput expression datasets. For more details please access the database (http://fantom.gsc.riken.jp/4/edgeexpress/)

Another study helps address major challenges in genomics including unravelling the orchestration of correct gene expression. FANTOM researchers have developed a suite of computer programs to identify chromatin conformation signatures, which could provide a completely novel class of human disease biomarkers. Further details of the software are available online at http://dostielab.biochem.mcgill.ca/

The international FANTOM4 research collaboration yielded a wide range of genome-scale data, including 24 million mRNA 5'-reads (CAGE tags) and microarray expression profiles along a differentiation time course of the human THP-1 cell line and data regarding chromatin status. These data are detailed in a new article from Genome Biology, and are also available as an integrated web resource (http://fantom.gsc.riken.jp/4/).

Further research published in BMC Bioinformatics highlights two new data-driven normalization methods for quantitative reverse transcriptase polymerase chain reaction (qPCR) experiments with larger data sets. Another study published in Genome Biology includes the first genome-wide analysis of EGR-1 binding sites implicated in cell differentiation in human monoblastoma THP-1 cells.

Dr. Harukazu Suzuki, the scientific coordinator said, "We are proud that we have created groundbreaking research in understanding more about how genes regulate cells at the molecular level and we want to acknowledge all consortium members for their great contribution to the research effort."

These are the first papers to be published from the consortium using BioMed Central's new cross-journal thematic series ability. And there are more to follow - a full list is available from the FANTOM4 series homepage (http://www.biomedcentral.com/series/FANTOM4)


'/>"/>

Contact: Charlotte Webber
charlotte.webber@biomedcentral.com
44-203-192-2216
BioMed Central
Source:Eurekalert

Related biology news :

1. Findings show insulin -- not genes -- linked to obesity
2. International climate change researchers meet, review latest findings
3. Therapeutic cloning gets a boost with new research findings
4. New research findings may enable earlier diagnosis of uterine cancer
5. Nearly a century later, new findings support Warburg theory of cancer
6. September 2007 Sumatran earthquakes research findings
7. More findings on gene involved in childhood asthma
8. Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings
9. International conference to release new findings on smell and taste
10. New findings on immune system in amphibians
11. Study findings show infection control intervention helps keep kids in school
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2016)... , March 10, 2016   Unisys Corporation ... and Border Protection (CBP) is testing its biometric identity ... San Diego to help identify certain non-U.S. citizens ... . The test, designed to help determine the efficiency and ... began in February and will run until May 2016. ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
(Date:3/3/2016)... March 3, 2016  2016FLEX, organized by FlexTech, ... highlighting advancements in flexible, hybrid and printed electronics. ... attendance - have gathered for short courses, technical ... of electronics. The Flex Conference celebrates its 15 ... companies, R&D organizations, and universities contributing to the ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... Cambridge Semantics, the leading ... today announced that it has been named to The Silicon Review’s “20 Fastest Growing ... other markets, Cambridge Semantics serves the needs of end users facing some of the ...
(Date:4/27/2016)... VANCOUVER, British Columbia , April 27, 2016 ... "Gesellschaft" oder "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( ... sie im Anschluss an ihre Pressemitteilung vom 13. ... Inc. erhalten hat, ihre Finanzen um zusätzliche 200.000.000 ... auf 4.000.000 Kanadische Dollar zu bringen. Davon wurden ...
(Date:4/27/2016)... , ... April 27, 2016 , ... ... PhD to its Scientific Advisory Board. Dr. Lamka will assist PathSensors in expanding ... detection. , PathSensors deploys the CANARY® test platform for the detection of ...
(Date:4/27/2016)... 27, 2016 MedDay, a biotechnology company ... the appointment of Catherine Moukheibir as Chairman of its Board ... Jean Jacques Garaud , who contributed to the rapid ... immediately. Catherine started her career in strategy consulting ... London .  She held C-Suite level roles ...
Breaking Biology Technology: