Navigation Links
Eye cells believed to be retinal stem cells are misidentified
Date:3/30/2009

al, and retinal progenitor cells, in particular, are not pigmented. Nevertheless, the previous finding was met with a tremendous amount of enthusiasm because of the promise of introducing these cells into the eye to regenerate photoreceptors lost to blindness."

In their studies, Dyer and his colleagues analyzed the sphere-forming cells in detail to determine whether they were really retinal stem cells. Painstaking microscopy studies of each cell in the spheres revealed all were pigmented and had features of ciliary epithelial cells. The researchers also compared the structure of the sphere-forming cells with those of confirmed stem cells and other immature cells in the developing retina called progenitor cells. That comparison revealed fundamental differences between the sphere-forming cells and established stem or progenitor cells.

The researchers also found that simply culturing the sphere-forming cells in the same growth medium as is used for stem cells caused them to activate genes characteristic of stem cells, yet remain adult ciliary epithelial cells.

Dyer said that a particularly promising alternative is the possibility of taking samples of adult cellssuch as fibroblasts that form connective tissuefrom a patient with retinal degeneration and exposing them to genetic cues that induce them to revert to stem cells. Those induced pluripotent stem cells could then be manipulated to develop into light-sensing photoreceptor cells that could then be transplanted into the patient's eyes to restore vision.

"This approach would solve many problems of developing cell-based therapy for blindness," Dyer said. "First, these cells are immortal, so they can be grown indefinitely to produce large amounts of cells for treatment. And secondly, they would be immunologically matched to the patient, so there would be no danger of rejection. And thanks to some excellent research during the past 15 years, we know a lot about how to reprogram such
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle
2. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
3. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
4. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
5. Human adult testes cells can become embryonic-like
6. Lab-on-a-chip homes in on how cancer cells break free
7. A sticky business -- how cancer cells become more gloopy as they die
8. Researchers identify new way the malaria parasite and red blood cells interact
9. Twin nanoparticle shown effective at targeting, killing breast cancer cells
10. Seeing stem cells helps in fight against peripheral arterial disease
11. Stem cells replace stroke-damaged tissue in rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 15, 2014 Research and ... the addition of the "Samsung Galaxy S5 ... report to their offering. ... a totally different sensing technology than the iPhone ... fingerprint sensor in its product. The ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... obesity has nearly tripled in the past three decades, and ... were classified as obese. If actions against childhood obesity do ... be the first generation in over a century to experience ... childhood obesity which leads to complications in later life. While ...
... is developing virtual models of human knee joints to ... to heavy loads virtual models that someday can ... aging process or by debilitating diseases, such as osteoarthritis. ... leveraging the powerful computing systems of the Ohio Supercomputer ...
... in immune system cells and epithelial cells (such as skin ... these peptides, human neutrophil peptide 1, under certain circumstances hinders ... HIV entry into mature T-helper cells (cells essential ... to specific targets on T-helper cells, uptake of the virus, ...
Cached Biology News:To understand childhood obesity, researchers look to inactive, fat rats 2To understand childhood obesity, researchers look to inactive, fat rats 3Researchers study knee stress at tissue, cellular levels 2Under the right conditions, peptide blocks HIV infection at multiple points along the way 2
(Date:12/24/2014)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ... clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), ... Meeting of Stockholders on May 4, 2015 (the "Annual ... Annual Meeting represents a change of more than 30 ...
(Date:12/24/2014)... BOSTON, MA (PRWEB) December 23, 2014 ... generation webinar series is designed to introduce ... and inform users and partners of platform ... features and benefits; empowering users in their ... and powerful tools. , According to SoundConnect’s ...
(Date:12/24/2014)... 2014 Nashville Fertility Center announced that ... for the American Society for Reproductive Medicine (ASRM), a ... in reproductive medicine. In his new role as ... executive board and will have a voice in furthering ... actively supported ASRM since 1984 when he joined while ...
(Date:12/24/2014)... 23, 2014 Vermillion, Inc. (Nasdaq:   ... disease, announced today that investors including Oracle Investment ... LLC and several Vermillion directors have agreed to ... Vermillion,s common stock and warrants to purchase unregistered ... placement.  Under the terms of ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... SAN FRANCISCO, Calif., Feb. 28 ,Exelixis, Inc. (Nasdaq: ... director of investor relations, will present at the,Susquehanna SIGnificant ... a.m. PT on Tuesday, March 4, 2008., The ... the Event,Calendar page under Investors on the Exelixis website ...
... /PRNewswire-FirstCall/ - Aeterna Zentaris Inc.,(NASDAQ: AEZS , ... therapy and oncology, will announce its fourth quarter ... open on,Wednesday, March 5, 2008. The Company will ... results later that same day at 10:00 a.m., ...
... InterMune, Inc.,(Nasdaq: ITMN ) today announced ... InterMune, will present at Susquehanna,s Second Annual,SIGnificant Options ... 5, 2008,at 2:30 p.m. EST., To access ... and other,interested parties may log on to the ...
Cached Biology Technology:InterMune to Present at the SIGnificant Options in Healthcare Conference 2
Contains 0.2 g/L EDTA4Na in phosphate-buffered saline....
... ,5-Bromo-4-chloro-3-indoxyl-beta-D-galactopyranoside C 14 H 15 ... ,M.W.= 408.63 ,Assay: Greater than ... DMF) ,Biological Activity: Blue color with ... Agrees with theoretical values ,Thin Layer ...
MHC Volumes 1 & 2...
BD IMagnet 1 each...
Biology Products: