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Extremely high estrogen levels may underlie complications of single-birth IVF pregnancies
Date:2/25/2013

ing the procedure until a future IVF cycle or proceeding with egg retrieval and fertilization but freezing the embryos for implantation in a later cycle to allow time for the ovary to recover.

The team's January Fertility and Sterility report compared the outcomes of 20 patients who choose to have their embryos frozen and implanted later because of their risk of OHSS with those of 32 patients with pre-retrieval estrogen levels over 3,450 pg/mL who proceeded with fresh embryo transfer. Only 10 percent of the infants of mothers who choose embryo freezing and transfer in a subsequent cycle were small for their gestational age, compared with 35 percent of the infants of mothers who had fresh embryo transfer. While the incidence of preeclampsia after fresh embryo transfer was almost 22 percent, none of the patients who chose embryo freezing with later implantation developed preeclampsia.

"Our center takes a very individualized and conservative approach to ovarian stimulation, so fewer than 10 percent of our patients had extremely high estrogen levels of greater than 3,450 pg/mL," says Imudia, who is an instructor in Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. "If other centers validate our findings by following the same approach and achieving similar outcomes, we would recommend that each patient's hormonal dosage be adjusted to try and keep her estrogen levels below 3,000 pg/mL. If the estrogen level exceeds this threshold, the patient could be counseled regarding freezing all embryos for transfer in subsequent cycles, when her hormone levels are closer to that of a natural cycle."


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Contact: Colleen Marshall
cmarshall3@partners.org
617-726-0275
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

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