Navigation Links
Extracting cellular 'engines' may aid in understanding mitochondrial diseases
Date:1/6/2011

Medical researchers who crave a means of exploring the genetic culprits behind a host of neuromuscular disorders may have just had their wish granted by a team working at the National Institute of Standards and Technology (NIST), where scientists have performed surgery on single cells to extract and examine their mitochondria.

The scientists reached into these cells and extracted their "engines"the mitochondria that are in large part responsible for our metabolism. Many human cells contain hundreds of mitochondria, which were thought to be free-swimming organisms millions of years ago and which still possess their own DNA. Mutations in this mitochondrial DNA (mtDNA) are directly related to a large class of mitochondrial-based diseases, which have a range of symptoms that include early onset blindness, seizures, hearing loss, dementia, etc. In the general population, one out of every 200 people possesses a mtDNA mutation that may develop into a mitochondrial disease.

Investigating more deeply has been problematic, though, because the way mitochondria mix and spread their DNA within and among cells is poorly understood. "The trouble is that it's very difficult to extract single mitochondria from an individual cell," says NIST physicist Joseph Reiner. "For years, the best technique has been to break open a group of cells and collect the mitochondria from all of them in a kind of soup. As you might guess, it's hard to determine which mitochondria came from what cellsyet that's what we need to know."

The research team, which also includes scientists from Gettysburg College, has potentially solved this problem by realizing that several devices and techniques can be used together to extract a single mitochondrion from a cell that possesses a genetic mutation. They employed a method** previously used to extract single chromosomes from isolated rice cells where a laser pulse makes an incision in a cell's outer membrane. Another laser is us
'/>"/>

Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert

Page: 1 2

Related biology news :

1. New book highlights the cellular and molecular determinants of brain wiring
2. Some cancer drugs may block cellular cross talk but not kill cancer cells
3. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
4. Massachusetts General Hospitals Warren Triennial Prize to honor pioneers of cellular reprogramming
5. Children with autism more likely to have mitochondrial defects impacting cellular energy production
6. Scientists discover molecular switch that contributes to cellular aging process
7. The most aggressive forms of breast cancer elude cellular control mechanisms in order to expand
8. UNC scientists identify cellular communicators for cancer virus
9. NYU Courant researchers develop algebraic model to monitor cellular change
10. Novel protein critical for cellular proliferation discovered
11. Ticking of cellular clock promotes seismic changes in the chromatin landscape associated with aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
(Date:12/11/2014)... SALEM, N.C. , Dec. 10, 2014  That blood ... for quite a while. Hypertension – the medical term for ... in the early 1800s, and the inflatable cuff that,s used ... That doesn,t, however, mean there,s nothing new about hypertension, its ... some long-held beliefs about the condition and the best ways ...
(Date:12/10/2014)... 9, 2014  Valencell, a leader in performance biometric ... staggering demand from its licensees for highly accurate, clinically ... not solely coming from fitness and health sectors, but ... "A wearable is only as useful as the biometric ... ultimate driver in long-term mass consumer adoption of wearable ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... A new study by the Wildlife Conservation Society, ... that habitat fragmentation and the addition of makeshift perches ... preferred habitat for common ravens that threaten sensitive ... The study appears in the January issue of the ...
... Renewable Energy Laboratory (NREL) have discovered that an enzyme from ... the Kamchatka Peninsula in Russia in 1990 can digest cellulose ... enzyme on the market. If the enzyme continues to ... the price of making lignocellulosic fuels, from ethanol to other ...
... 2014 -- Although drugs have been developed that inhibit the ... which causes many brain disorders and nervous system diseases ... work has not yet been fully explained. Now, ... as a model, have deciphered the mode by which the ...
Cached Biology News:Might more ravens -- aided by humans -- mean 'nevermore' for sage-grouse? 2Might more ravens -- aided by humans -- mean 'nevermore' for sage-grouse? 3NREL finds a new cellulose digestion mechanism by a fast-eating enzyme 2NREL finds a new cellulose digestion mechanism by a fast-eating enzyme 3Neurotransmitters resarch can promote better drugs for brain disorders 2Neurotransmitters resarch can promote better drugs for brain disorders 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... Wyeth,Pharmaceuticals, a division of Wyeth (NYSE: WYE ... the 63rd Annual Meeting of the American Society ... 100 mg/day or,150 mg/day of desvenlafaxine, a serotonin ... in moderate to severe,vasomotor symptoms (VMS) (hot flashes ...
... Cellmark Inc.,(Nasdaq: ORCH ), a leading worldwide ... third quarter 2007 financial results on,Thursday, November 1, ... hosting a,conference call and webcast to discuss the ... Management will discuss financial results for the third ...
... Technique to be Presented at American ... Meeting -, - Improved Techniques Could Lead to ... well as PGD with In Vitro Fertilization -, ... developing high throughput technologies that enable genome-wide,analyses, and Reprogenetics, ...
Cached Biology Technology:Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo 2Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo 3Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo 4Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo 5Orchid Cellmark to Announce Third Quarter 2007 Financial Results on November 1, 2007 2Empire Genomics and Reprogenetics Join Forces to Improve Preimplantation Genetic Diagnosis (PGD) 2Empire Genomics and Reprogenetics Join Forces to Improve Preimplantation Genetic Diagnosis (PGD) 3
...
...
SphingoStripsTM contain fifteen different biologically active, nitrocellulose-immobilized lipids at 100 pmol per spot, which can be assayed for protein binding and specificity using a simple blot ove...
The Discovery Series PDQuest 2-D analysis software is used for imaging, analyzing, and databasing two-dimensional electrophoretic gels. The version upgrade allows upgrade of an established version of...
Biology Products: