Navigation Links
Extra chromosome 21 removed from Down syndrome cell line
Date:11/9/2012

University of Washington scientists have succeeded in removing the extra copy of chromosome 21 in cell cultures derived from a person with Down's syndrome. In Down syndrome, the body's cells contain three copies of chromosome 21, rather than the usual pair.

A triplicate of any chromosome is a serious genetic abnormality called a trisomy. Trisomies account for almost one-quarter of pregnancy loss from spontaneous miscarriages, according to the research team. Besides Down syndrome (trisomy 21), some other human trisomies are extra Y or X chromosomes, and Edwards syndrome (trisomy 18) and Patau syndrome (trisomy 13), both of which have extremely high newborn fatality rates.

In their report appearing in the Nov. 2 edition of Cell Stem Cell, a team led by Dr. Li B. Li of the UW Department of Medicine described how they corrected trisomy 21 in human cell lines they grew in the lab. The senior scientists on the project were gene therapy researchers Dr. David W. Russell, professor of medicine and biochemistry, and Dr. Thalia Papayannopoulou, professor of medicine.

The targeted removal of a human trisomy, they noted, could have both clinical and research applications. In live births, Down syndrome is the most frequent trisomy. The condition has characteristic eye, facial and hand features, and can cause many medical problems, including heart defects, impaired intellect, premature aging and dementia, and certain forms of leukemia, a type of blood cancer.

"We are certainly not proposing that the method we describe would lead to a treatment for Down syndrome," Russell said. "What we are looking at is the possibility that medical scientists could create cell therapies for some of the blood-forming disorders that accompany Down syndrome."

For example, he said, someday Down syndrome leukemia patients might have stem cells derived their own cells, and have the trisomy corrected in these lab-cultured cells. They cou
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Western aspen trees commonly carry extra set of chromosomes
2. Plants fungi allies may not help store climate changes extra carbon
3. Strawberry extract protects against UVA rays
4. China Botanic Receives Patent on its Schisandra Lignin Extraction Method
5. Beehive extract shows potential as prostate cancer treatment
6. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
9. Study of fruit fly chromosomes improves understanding of evolution and fertility
10. Men can rest easy - sex chromosomes are here to stay
11. Discovery reveals chromosomes organize into yarns
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Extra chromosome 21 removed from Down syndrome cell line
(Date:7/11/2014)... the Wildlife Conservation Society shows that no-take zones ... species such as lobster, conch, and fish recover ... reef areas. , The reporttitled "Review of the ... research literature from no-take areas around the world. ... a recognized expert in marine protected areas and ...
(Date:7/11/2014)... Tenn., July 11, 2014--Researchers at the Department of ... R&D 100 awards, presented by R&D Magazine in ... , "These awards recognize the tremendous value of ... Moniz. "Research and development at the National Labs ... challenges and pursue the scientific and technological innovations ...
(Date:7/11/2014)... New South Wales, Australia when NASA,s Aqua satellite passed ... July 11 (12:35 p.m. local time/11:35 p.m. EDT on ... Wales (NSW), the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... spotted smoke (light brown) from various fires. Actively burning ... red. , The New South Wales, Australia Government website ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... than 99 percent of all modern potato varieties planted ... grew in the lowlands of south-central Chile. How Chilean ... from Europe-has been the subject of a long, contentious ... have maintained that Chilean potatoes were the first to ...
... Management and Budget evaluates R&D programs at the U.S. ... that asks about many aspects of their research, including ... answers, and an "ineffective" rating can have serious adverse ... trouble meeting OMB,s requirements to measure and demonstrate efficiency, ...
... ON. January 29, 2007 A new study sheds ... pregnantor are exposed to second-hand smokeand an increased risk ... University have found a mechanism that explains why an ... a hypoxic episodeis dramatically compromised by exposure to nicotine ...
Cached Biology News:Using DNA, scientists hunt for the roots of the modern potato 2New research explains link between smoking and SIDS 2
(Date:7/13/2014)... 2014 2014 Deep Research Report on ... and in-depth study on the current state of the ... report provides a basic overview of the industry, including ... and Chinese domestic market analysis are provided with a ... the market. A comparison between the international and Chinese ...
(Date:7/12/2014)... York (PRWEB) July 12, 2014 ... for various reagents used in the life ... driving the life science reagents market towards ... include manufacturers and providers of life science ... Market Report: http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . , The ...
(Date:7/11/2014)... PALM BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ ... variety of high-quality peptides that are used solely in ... To honor two successful years in business, Maxim Peptide, ... LLC, has just launched a new and updated website ... the research blog section has been updated with fascinating ...
(Date:7/11/2014)... , July 11, 2014 , ... part) in, into or from any jurisdiction where to do ... such jurisdiction.  Shire plc ("Shire" or the "Company") ... article this afternoon.  Shire confirms it has held a meeting ... made by Shire without the prior agreement or approval of ...
Breaking Biology Technology:2014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Shire plc - Statement re: Media Speculation 2
... that TechStar will receive a two-year grant from the ... research institutions in Milwaukee, which for years trailed their ... are aspiring to catch up. Thats good news for ... economy. , ,If Milwaukee wants to transform itself from ...
... in the field and navigating at the helm of several ... (which is located in Woodridge, Ill. across from Argonne ... advance his drug discovery company. , ,Following a six-month ... the next few weeks with financial adviser Legg Mason ...
... WI - Automating Peripherals Inc announced that the ... security standards mandated by the Health Insurance Portability ... Commission on Accreditation of Healthcare Organizations (JCAHO). SecurALL ... organizations regulate and monitor facility access throughout an ...
Cached Biology Technology:Milwaukee research institutions step up the pace for technology transfer 2Advanced Life Sciences to Hit the Road For $30 Million in Funding 2Advanced Life Sciences to Hit the Road For $30 Million in Funding 3Advanced Life Sciences to Hit the Road For $30 Million in Funding 4
...
... PlusOne Silver Staining Kit, Protein, 1. ... and Dernick (1), the kit gives ... electrophoresis systems.Silver Staining Kit, Protein provides ... proteins in polyacrylamide gels in less ...
Mouse monoclonal [IFR0104] to Salmonella enteriditis ( Abpromise for all tested applications)....
Cyno macaque plasma and serum - various quantities available...
Biology Products: