Navigation Links
Exposure to antibiotics linked to severity of allergic asthma: UBC research
Date:3/16/2012

Widely used antibiotics may increase incidence and severity of allergic asthma in early life, according to a University of British Columbia study.

The study, published today in the journal EMBO reports, shows that certain antibiotics that affect intestinal bacteria also had a profound impact on allergic asthma.

"It has long been suspected that kids exposed to more antibiotics like those in developed countries are more prone to allergic asthma," says the study's author, UBC microbiologist Brett Finlay. "Our study is the first experimental proof that shows how."

Finlay's team at UBC's Dept. of Microbiology and Immunology and Michael Smith Laboratories examined how two widely used antibiotics streptomycin and vancomycin affected the bacterial "ecosystem" in the gut. They found that vancomycin profoundly alters the bacterial communities in the intestine and increases severity of asthma in mouse models.

The same antibiotics do not impact adult mice's susceptibility to asthma, indicating that early life is a critical period of establishing a healthy immune system.

Allergic asthma affects more than 100 million people worldwide and its prevalence is increasing on average by 50 per cent every decade, particularly among children in industrialized countries. According to the Asthma Society of Canada, asthma affects at least 12 per cent of Canadian children.

The human gut is colonized by approximately 100 trillion bacteria, and contains upwards of 1,000 bacterial species. While not fully understood, these micro-organisms, known as "gut flora," perform a host of useful functions, says Finlay.

"Modern societal practices, such as improved sanitation methods and widespread antibiotic use, are causing the disappearance of ancestral species of bacteria in our gut that may be critical to a healthy immune system," says Finlay.

"Our study shows this is the case with certain antibiotics and allergic asthma, and the gut-lung connection is also consistent with observations that incidence of asthma has not increased significantly in developing countries where antibiotic use is less prevalent and in turn, the gut flora is permitted to fully develop."

The study is funded by the Canadian Institutes of Health Research (CIHR) through the Canadian Microbiome Initiative, in partnership with Genome BC and the Allergy, Genes and Environment Network (AllerGen NCE).

Marc Ouellette, Scientific Director of CIHR's Institute of Infection and Immunity, noted the importance of the team's results: "It has been recognized that microbes play an important role in human health and we are discovering that a disruption of these bugs is associated with a number of chronic health conditions. The important results from Prof. Finlay's team confirm that giving antibiotics to young children, which disturb their normal bacterial flora, should not be taken lightly."


'/>"/>
Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related biology news :

1. Study: Bird diversity lessens human exposure to West Nile Virus
2. Birth control has long-term effect on hormone exposure
3. Major source of radon exposure overlooked at former Ohio uranium-processing plant
4. Household exposure to toxic chemicals lurks unrecognized, researchers find
5. Study reveals effects of unconscious exposure to advertisements
6. Benefits of breastfeeding outweigh risk of infant exposure to environmental chemicals in breastmilk
7. Novel technique changes lymph node biopsy, reduces radiaiton exposure
8. Novel technique changes lymph node biopsy, reduces radiation exposure
9. Swimmers at public beaches show increased risk of exposure to contagious staph bacteria
10. How increased UV exposure impacts plants
11. Exposure to insecticide may play role in obesity epidemic among some women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... AUSTIN, Texas , Dec. 1, 2016 /PRNewswire/ ... provider, today announced BioLock , an electrocardiogram ... and health monitoring, a key IoT asset. The ... embedded into a vehicle,s steering wheel and mobile ... a simple touch. As vehicle technology ...
(Date:11/29/2016)... , Nov. 29, 2016 BioDirection, a privately ... products for the objective detection of concussion and other ... has successfully completed a meeting with the U.S. Food ... blood test Pre-Submission Package. During the meeting company representatives ... as a precursor to commencement of a planned pilot ...
(Date:11/28/2016)... "The biometric system market projected to ... system market is in the growth stage and is ... biometric system market is expected to be valued at ... 16.79% between 2016 and 2022. Government initiative in adoption ... rising use of biometric technology in financial institutes and ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... Research and Markets has announced the addition of Jain ... Companies" to their offering. ... , , ... development of sequencing technologies, and their applications. Current large and ... Various applications of sequencing are described including those for genetics, ...
(Date:12/4/2016)... CAMBRIDGE, Mass. and ... 2016 SystemOne, a company focused on ... for the developing world, and Daktari Diagnostics, a ... with its portable and ultrasensitive immunoassay-based CarePlatform™, today ... and license agreement to integrate Daktari,s technology platform ...
(Date:12/2/2016)... CytRx Corporation (NASDAQ: CYTR ), ... today announced the appointment of Earl Warren Brien ... private healthcare investor, to its Board of Directors. ... and strategic experience at the highest level," said ... one of the world,s leading orthopedic surgeons, Dr. Brien ...
(Date:12/2/2016)... , ... December 01, 2016 , ... ... Science Symposium (CSS) and the popularity of US Single Day Events (SDE) to ... in early Summer 2018, in Raleigh, NC. Topics of the pharmaceutical and life ...
Breaking Biology Technology: