COLUMBIA, Mo. A new University of Missouri study shows that the exposure to the controversial chemical Bisphenol A (BPA) through diet has been underestimated by previous lab tests. In the study, researchers compared BPA concentrations in mice that were given a steady diet supplemented with BPA throughout the day, compared to the more common lab method of single exposure, and found an increased absorption and accumulation of BPA in the blood of mice.
This is the first study to examine concentrations of BPA in any animal models after exposure through a regular, daily diet, which is a better method to mirror the chronic and continuous exposure to BPA that occurs in animals and humans. Cheryl Rosenfeld, associate professor in biomedical sciences and Bond Life Sciences investigator, is the corresponding lead author of the study published in Environmental Health Perspectives on June 6.
The authors continuously exposed the mice to BPA through their feed, which is considered the primary route of exposure to this chemical in animals and humans. In previous studies examining the effects of BPA, mice were exposed to BPA only through a one-time administration. Following the exposure through the diet, a significantly greater increase in the active form of BPA, which is the greatest threat as it is the form that can bind to sex steroid receptors and exert adverse effects, was absorbed and accumulated in the animals.
"People are primarily and unknowingly exposed to BPA through the diet because of the various plastic and paper containers used to store our food are formulated with BPA," Rosenfeld said. "We know that the active form of BPA binds to our steroid receptors, meaning it can affect estrogen, thyroid and testosterone function. It might also cause genetic mutations. Thus, this chemical can hinder our ability to reproduce and possibly cause behavioral abnormalities that we are just beginning to understand."
The study notes tha
'/>"/>
| Contact: Steven Adams AdamsST@missouri.edu 573-882-8353 University of Missouri-Columbia Source:Eurekalert |
Related biology news :
1. New study suggests link between chronic estrogen exposure and high blood pressure
2. CDC assesses potential human exposure to prion diseases
3. Parental exposure to BPA during pregnancy associated with decreased birth weight in offspring
4. Prenatal exposure to certain pesticides may negatively impact cognitive development in children
5. Prenatal pesticide exposure tied to lower IQ in children
6. Air pollution exposure affects chances of developing premenopausal breast cancer
7. OSU chemist developing solution to nerve agent exposure
8. Antioxidant formula prior to radiation exposure may prevent DNA injury
9. Exposure to worm infection in the womb may protect against eczema, study suggests
10. Perinatal bisphenol-A exposure may affect fertility
11. Exposure of humans to cosmetic UV filters is widespread
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |