Navigation Links
Exposure to Agent Orange linked to prostate cancer in Vietnam veterans
Date:8/5/2008

(SACRAMENTO, Calif.) UC Davis Cancer Center physicians today released results of research showing that Vietnam War veterans exposed to Agent Orange have greatly increased risks of prostate cancer and even greater risks of getting the most aggressive form of the disease as compared to those who were not exposed.

The findings, which appear online now and will be published in the September 15 issue of the journal Cancer, are the first to link the herbicide with this form of cancer. The research is also the first to utilize a large population of men in their 60s and the prostate-specific antigen (PSA) test to screen for the disease.

"While others have linked Agent Orange to cancers such as soft-tissue sarcomas, Hodgkin's disease and non-Hodgkin's lymphoma, there is limited evidence so far associating it with prostate cancer," said Karim Chamie, lead author of the study and resident physician with the UC Davis Department of Urology and the VA Northern California Health Care System. "Here we report on the largest study to date of Vietnam War veterans exposed to Agent Orange and the incidence of prostate cancer."

Chamie also said that, unlike previous studies that were either too small or conducted on men who were too young, patients in the current study were entering their prime years for developing prostate cancer. There was also the added advantage that it was conducted entirely during the era of PSA screening, providing a powerful tool for early diagnosis and tracking of prostate cancer.

More than 13,000 Vietnam veterans enrolled in the VA Northern California Health Care System were stratified into two groups exposed or not exposed to Agent Orange between 1962 and 1971. Based on medical evaluations conducted between 1998 and 2006, the study revealed that twice as many men exposed to Agent Orange were identified with prostate cancer. In addition, Agent Orange-exposed men were diagnosed two-and-a-half years younger and were nearly four times more likely to present with metastatic disease. Other prostate cancer risk factors race, body-mass index and smoking were not statistically different between the two groups.

"Our country's veterans deserve the best possible health care, and this study clearly confirms that Agent Orange exposure during service in Vietnam is associated with a higher risk of prostate cancer later in life," said Ralph deVere White, UC Davis Cancer Center director and a study co-author. "Just as those with a family history of prostate cancer or who are of African-American heritage are screened more frequently, so too should men with Agent Orange exposure be given priority consideration for all the screening and diagnostic tools we have at our disposal in the hopes of early detection and treatment of this disease."

Now a banned chemical, Agent Orange is a combination of two synthetic compounds known to be contaminated with the dioxin tetrachlorodibenzo-para-dioxin (TCDD) during the manufacturing process. Named for the color of the barrel in which it was stored, Agent Orange was one of many broad-leaf defoliants used in Vietnam to destroy dense forests in order to better visualize enemy activity.

It is estimated that more than 20 million gallons of the chemicals, also known as "rainbow herbicides," were sprayed between 1962 and 1971, contaminating both ground cover and ground troops. Most of the rainbow herbicide used during this time was Agent Orange. In 1997, the International Agency for Research on Cancer reclassified TCDD as a group 1 carcinogen, a classification that includes arsenic, asbestos and gamma radiation.


'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

Related biology news :

1. Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold
2. Chronic exposure to estrogen impairs some cognitive functions
3. OSU study shows exposure to bad air raises blood pressure
4. Early exposure to common weed killer impairs amphibian development
5. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
6. Low exposure to asbestos-like mineral from Montana vermiculite may up lung disease risk
7. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
8. MIT: Prenatal arsenic exposure detected in newborns
9. Time spent in car drives up air pollution exposure
10. Nanoparticle exposures happen, says expert
11. Researchers developing device to predict proper light exposure for human health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... 6, 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... offering of €500.0 million principal amount of its 1.414% senior ... its 2.425% senior unsecured notes due 2026. ... December 13, 2016, subject to the satisfaction of customary closing conditions.  ... The Company intends to use the ...
(Date:12/2/2016)... 1, 2016 The report "Biometric ... Future Technology (Iris Recognition System), Vehicle Type (Passenger ... Forecast to 2021", published by MarketsandMarkets, the market ... 2016, and is projected to grow to USD ... 14.06%.      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/29/2016)... Nov. 29, 2016 BioDirection, a privately held ... for the objective detection of concussion and other traumatic ... successfully completed a meeting with the U.S. Food and ... test Pre-Submission Package. During the meeting company representatives reviewed ... a precursor to commencement of a planned pilot trial. ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Biotheranostics today ... the role of the Breast Cancer Index (BCI) ... breast cancer are most at-risk for disease recurrence ... include results from three studies advancing the understanding ... related to tumor biology and inform decisions related ...
(Date:12/8/2016)... , December 8, 2016 ... Unternehmen für Molekulargenetik, erweitert seine Palette an anpassbaren ... NGS Custom FH Panels, das ein schnelles und ... ermöglicht. Das Panel bietet eine Erkennung von Einzel-Nukleotid-Variationen ... (CNV) mit einem einzigen kleinen Panel und ermöglicht ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... the World Technology Awards. uBiome is one of just six company finalists in ... , In addition to uBiome, companies nominated as finalists in this year’s awards ...
(Date:12/8/2016)... N.J. , Dec. 8, 2016 ... augmentation remediation technologies and selected NewTechBio,s NT-MAX ... a microbial based beneficial bacteria, in conjunction with ... to correct deficiencies with National Pollutant Discharge Elimination ... 281-8H has experienced a steady history of elevated ...
Breaking Biology Technology: