Navigation Links
Exploding chromosomes fuel research about evolution of genetic storage
Date:8/21/2008

dense?" Levi-Setti asked. "Most biology books do not tell you."

Other scientists had already identified positively charged atoms called cations as neutralizing factors. They found that dinoflagellate chromosomes explode upon the removal of calcium and magnesium cations.

Levi-Setti has produced the first images of the distribution of these cations in dinoflagellate chromosomes. These images verify that cations, mainly of calcium and magnesium, neutralize DNA's enormous negative charge, and further suggest a critical role in folding the protein as well.

The finding raises questions about the evolution of chromosomes, Rizzo said. "Did dinoflagellates once have histones and then lost them? Or did dinoflagellates never have histones and just 'figured out' a different way to fold large amounts of DNA into chromosomes?" Rizzo asked.

The images were produced using a high-resolution scanning ion microprobe, an instrument that Levi-Setti developed in the 1980s jointly with Hughes Research Laboratories in Malibu, Calif. For the last 15 years, Levi-Setti has collaborated with associates of pioneering chromosome researcher Janet Rowley, the Blum-Riese Distinguished Service Professor in Medicine, Molecular Genetics & Cell Biology and Human Genetics at the University of Chicago.

In 2001, the collaboration demonstrated that cations play an important role in compacting mammalian DNA and helping chromosomes maintain their structure. "Chromosomes would fall apart when calcium and magnesium were removed," Levi-Setti said.

Wondering if there could be a fundamental evolutionary process at work, Levi-Setti extended his research to the fruit fly. Like mammals, fruit flies belong to the pantheon of eukaryotes. In contrast to prokaryotes like bacteria, eukaryotes pack their genetic material in a cellular nucleus. Prokaryotes lack a nucleus.

"Cations play a very important role in the folding and charge neutralization of DNA in all
'/>"/>

Contact: Steve Koppes
s-koppes@uchicago.edu
773-702-8366
University of Chicago
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant supports study of abnormal ring-shaped chromosomes
2. Fungi can tell us about the origin of sex chromosomes
3. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
4. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
5. Research shows skeleton to be endocrine organ
6. Newly created cancer stem cells could aid breast cancer research
7. Dominant cholesterol-metabolism ideas challenged by new research
8. Researchers identify proteins involved in new neurodegenerative syndrome
9. Texas researchers and educators head for Antarctica
10. MGH researchers describe new way to identify, evolve novel enzymes
11. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Exploding chromosomes fuel research about evolution of genetic storage
(Date:5/20/2015)... , May 20, 2015 NXT-ID, Inc. (NASDAQ: ... its wholly owned subsidiary, 3D-ID LLC, a company engaged ... Battelle for the biometrics technology portion of the recently ... from the Department of the Army. 3D-ID ... developed for government, law enforcement and security agencies. ...
(Date:5/19/2015)... -- Technology is rapidly advancing, outpacing enterprises, ability to secure ... and their management are soon to be rendered obsolete ... as those developed by the FIDO Alliance™. With the ... BYOD, COPE, IoT, and mobile payments, the interconnected online ... In response to the call for seamless, secure, ...
(Date:5/18/2015)... May 18, 2015 Fingerprint Cards (FPC) ... FPC1025, FPC1145, FPC1155 and FPC1035 from one if its module ... and including Q3 2015 and the sensors will be used ... order values for 2015 hereby amount to 740 MSEK to ... of 140 MSEK and a number of smaller orders not ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... unexpected discovery in marine biomedical laboratories at Scripps Institution ... new, key information about the fundamental biological processes inside ... being tested to treat cancer in humans. The finding ... in treating human diseases. A research team led ...
... raw ingredients into food since prehistoric times. But ... food taste better and survive longer. Presenting ... and European Cooperation in the field of Scientific and ... technologies are changing European diets. , The industrial revolution ...
... overweight and obese Americans continues to grow rapidly. Today, 50 ... are obese. While the number of overweight/obese children is at ... -- individuals under 11 months old -- is alarming. ... overweight/obese are more likely to give birth to heavier babies, ...
Cached Biology News:Researchers uncover key trigger for potent cancer-fighting marine product 2Food for thought: delivering the promise of food processing 2Mom's obesity during conception phase may set the stage for offspring's obesity risk 2Mom's obesity during conception phase may set the stage for offspring's obesity risk 3Mom's obesity during conception phase may set the stage for offspring's obesity risk 4
(Date:5/28/2015)... May 28, 2015  GenVec, Inc. (Nasdaq: GNVC ... Douglas J. Swirsky , will present a company overview ... a.m. EDT on Thursday, June 4, 2015. ... presentation will be available at the following link:  ... GenVec,s website.  To access, visit www.genvec.com , click ...
(Date:5/28/2015)... Whitehouse Laboratories is excited to announce that ... with PTI Inspection Systems. Whitehouse Labs and PTI will ... method development and validation programs using the most ... includes a more formal program that facilitates cross training ... enables a more effective team approach, especially as it ...
(Date:5/28/2015)... 2015 In two different WPC ... M.D., Ph.D., will present the company’s unique approach to ... conference talk, he will describe Asymmetrex ’s innovation ... computer simulation to produce the first-ever technology for quantitative ... over time in culture. When leading an interactive ...
(Date:5/27/2015)... 2015 Research and Markets ( ... Jain PharmaBiotech,s new report "Molecular Diagnostics ... their offering. This report describes ... will play an important role in practice ... and biological warfare in the 21st century. ...
Breaking Biology Technology:GenVec To Present At The Jefferies Healthcare Conference 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 2Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 3
... Feb. 19 National Stem,Cell Holding, Inc. (OTC: ... Securities, Inc. ("BMA Securities") to provide advisory and,investment ... the,company with a current capital raise of $3,500,000., ... service brokerage firm. BMA,Securities offers a wide array ...
... 19 Inverseon, Inc.,( http://www.inverseon.com ) announces ... research led by Professor Richard Bond of,the ... the March,article by Nguyen, et. al., in ... Biology 2008; 38: 256-262, entitled, "Chronic Exposure ...
... Stem Cell Therapy in SMA,will begin in early 2008, ... Atrophy (FSMA); a stem cell scientist at University of,California, ... pleased,to announce a partnership to advance a potential stem ... set of animal studies planned, which,will be conducted in ...
Cached Biology Technology:National Stem Cell Holding, Inc. Has Engaged BMA Securities to Assist and Advise the Company With Its Current Capital Raise of $3,500,000 2Drug Reduces Airway Mucus in Preclinical Asthma Model 2Families of Spinal Muscular Atrophy; University of California, Irvine Stem Cell Scientist; and California Stem Cell Announce Collaboration for Safety Studies for Stem Cell Therapy in Spinal Muscular Atrophy 2Families of Spinal Muscular Atrophy; University of California, Irvine Stem Cell Scientist; and California Stem Cell Announce Collaboration for Safety Studies for Stem Cell Therapy in Spinal Muscular Atrophy 3
... Fixed clamp trays and universal trays ... Magnetic drive Shaking speed: ... 25 mm amplitude Clamps ... 2000 ml, including Fernbach flasks ...
... is a fluorescent microscopy-based imaging system that ... and automatically calculates cell viability, in a ... function, the variability associated with the subjective ... Using the EasyCount ViaSure Kit, up to ...
... faster than western blotting. Get results sooner and ... on gel detection. Eliminates the need for a ... All reagents are ready-to-use. No reagents to ... Only 2 reagents required. Guarantees a simple to ...
... variable angle system, 220-240 V, is used to ... DNA fragments by pulsed field gel electrophoresis (PFGE). ... variable-speed pump, 14 x 13 cm casting stand ... mm thick comb, screened cap, disposable plug molds, ...
Biology Products: