Navigation Links
Experts propose 'cyber war' on cancer
Date:9/4/2012

HOUSTON -- (Sept. 4, 2012) -- In the face of mounting evidence that cancer cells communicate, cooperate and even engage in collective decision-making, biophysicists and cancer researchers at Rice University, Tel Aviv University and Johns Hopkins University are suggesting a new strategy for outsmarting cancer through its own social intelligence.

"We need to get beyond the notion that cancer is a random collection of cells running amok," said Herbert Levine, co-director of Rice's Center for Theoretical Biological Physics (CTBP) and co-author of the cover article in this week's Trends in Microbiology that pulls together dozens of recent discoveries about the social behavior of cancer cells. "These cells lead sophisticated social lives."

Article co-author Eshel Ben-Jacob, a senior investigator at CTBP, said, "Cancer is a sophisticated enemy. There's growing evidence that cancer cells use advanced communications to work together to enslave normal cells, create metastases, resist drugs and decoy the body's immune system."

Ben-Jacob, Levine and Donald Coffey, a noted cancer researcher at Johns Hopkins, suggest in the article that cancer researchers act like modern generals and go after their enemy's command, control and communication capabilities. The article is in volume 20, issue 9, pages 403-410 of the journal.

"It's time to declare a cyber war on cancer," said Ben-Jacob, who, along with Coffey, is speaking today at a workshop titled "Failures in Clinical Treatment of Cancer" at Princeton University.

Ben-Jacob said cancer cells have been shown to cooperate to elude chemotherapy drugs, much like bacteria that communicate and act as a team to resist attacks from antibiotics. He said some cancers appear to sense when chemotherapy drugs are present and sound an alarm that causes cells throughout a tumor to switch into a dormant state. Similar signals are later used to sound the "all clear" and reawaken cells inside the tumor.

"If we can break the communication code, we may be able to prevent the cells from going dormant or to reawaken them for a well-timed chemotherapeutic attack," Ben-Jacob said. "This is just one example. Our extensive studies of the social lives of bacteria suggest a number of others, including sending signals that trigger the cancer cells to turn upon themselves and kill one another."

The article cites numerous examples of similarities between the behavior of bacterial colonies and cancerous tumors.

"The parallels between the communal behaviors of bacteria and cancer cells suggest that bacteria can serve as a valuable model system for studying cancer," said Coffey, professor of urology, oncology, pathology and pharmacology and molecular sciences at the Johns Hopkins University School of Medicine. "We believe this approach could be particularly valuable for investigating intractable problems like metastasis, relapse and multiple drug resistance."

Levine, Rice's Karl F. Hasselmann Professor in Bioengineering, and fellow CTBP co-director Jos Onuchic were recruited to Houston last year, thanks in part to a grant from the Cancer Prevention and Research Institute of Texas (CPRIT) that was designed to spur new thinking about cancer and foster collaborations between CTBP scientists and cancer specialists in the Texas Medical Center.

"This opinion article reflects the multidisciplinary strategy of the CTBP -- to communicate and work together with researchers across disciplines for solving the biomedical challenges of our time," said Onuchic, Rice's Harry C. and Olga K. Wiess Professor of Physics and Astronomy and professor of chemistry.

Ben-Jacob, the Maguy-Glass Chair in Physics of Complex Systems and professor of physics and astronomy at Tel Aviv University, worked previously with Levine and Onuchic on a number of groundbreaking studies about the underlying biophysics of bacterial social behavior. He joined Rice University this summer as senior investigator of the CTBP and adjunct professor of chemistry and cell biology.


'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Related biology news :

1. Major migration of bird experts flock to Vancouver
2. World experts meet in Edinburgh to consider how life experiences impact on our genes
3. Divide the Antarctic to protect native species, propose experts
4. Coral reef experts to present latest coral reef science during July symposium
5. Smell and taste experts to discuss new discoveries
6. Worlds leading coral experts to gather in Australia
7. Updated DHS report on risks of proposed Kansas biocontainment lab
8. Jim Demitrieus, CEO of EyeLock, Invited to White House Cyber Security Event
9. Velvet spiders emerge from underground in new cybertaxonomic monograph
10. New study shows promise in using RNA nanotechnology to treat cancers and viral infections
11. U of M researchers: Newly discovered genetic markers could signal colon cancer development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Experts propose 'cyber war' on cancer
(Date:1/22/2016)... , January 22, 2016 /PRNewswire/ ... announced the addition of the  "Global ... their offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ...
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
(Date:1/11/2016)... 2016 Synaptics Incorporated (NASDAQ: SYNA ), ... that its ClearPad ® TouchView ™ 4300 ... separate categories in the 8 th Annual Mobile ... Breakthrough. The Synaptics ® TDDI solution enables faster ... thinner devices, brighter displays and borderless designs. ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... February 11, 2016 ... or "Company") (OTCQB: PSID), a life sciences company ... its Thermomedics subsidiary, which markets the Caregiver® FDA-cleared ... plan in January 2016, including entering into agreements ... monthly sales growth, and establishing several near-term pipeline ...
(Date:2/10/2016)... Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... announce that Mitsui & Co. Ltd., its partner in ... plant, is investing an additional CDN$25 million in the ... stake from 30% to 40%.  Mitsui will also play ... produced in Sarnia , providing dedicated ...
(Date:2/10/2016)... York (PRWEB) , ... February ... ... (NASDAQ: REGN) today announced that it has joined the Human Vaccines Project, ... for infectious diseases and cancer. , The Human Vaccines Project brings ...
(Date:2/10/2016)... ... 2016 , ... HOLLOWAY AMERICA, a leading custom stainless steel ... Chapter 21st Annual Vendor Exhibition on Thursday, February 18, 2016. The Rocky Mountain ... annual event, which will run from 3:00 p.m. - 8:30 p.m. at The ...
Breaking Biology Technology: