Navigation Links
Experts from Stevens, Merck, publish joint paper, 'Biosynthetic Studies of Platensimycin'
Date:12/6/2007

HOBOKEN, N.J. Stevens Institute of Technologys Professor Athule B. Attygalle and his doctoral student Kithsiri B. Herath have collaborated with Merck Pharmaceuticals Dr. Sheo B. Singh on a study whose findings have been published in the Journal of the American Chemical Society, in a paper titled Biosynthetic Studies of Platensimycin (Herath, K. B.; Attygalle, A. B.; Singh, S. B. J. Am. Chem. Soc.; [Communication]; 2007; ASAP Article; DOI: 10.1021/ja0758943from academia and industry).

It reports biosynthesis of a novel antibiotic, said Attygalle. It is the product of a rewarding research effort done with Merck, with Dr. Singhs participation.

Platensimycin (1) and platencin (2), two novel antibiotics, were recently isolated from several strains of Streptomyces platensis.

They impart their potent Gram-positive antibacterial activity, including that against drug-resistant organisms (e.g., MRSA, VRE), by uniquely inhibiting acyl enzyme intermediates of the condensing enzymes FabF and FabF/FabH, respectively, vital for fatty acid biosynthesis.

Both compounds are highly efficacious in vivo when administered by continuous infusion; however, the efficacy is reduced when administered by conventional routes. This phenomenon is attributed to their poor pharmacokinetic properties which could potentially be improved by chemical modification of the natural product, via total synthesis and through combinatorial biosynthesis.

Understanding biosynthetic pathways leading to the biosynthesis of both compounds is a prerequisite for combinatorial biosynthesis and is also helpful for improvement of the titer of these compounds in the producing organism. The report details the resultsof biosynthetic studies of platensimycin by stable-isotope precursor incorporation experiments.


'/>"/>

Contact: Patrick A. Berzinski
pberzins@stevens.edu
201-216-5687
Stevens Institute of Technology
Source:Eurekalert

Page: 1

Related biology news :

1. Leading experts cite poor health and nutrition as major barrier to education in developing world
2. Improving science, technology in Africa is aim as G-8, African, UN experts convene in Berlin
3. Less Arctic ice means higher risks, experts warn
4. Soil, conservation experts to reflect on Hurricane Katrina disaster
5. Now is Africas turn for a green revolution, global experts say
6. Agriculture experts meet in Beijing to examine impacts of food prices and climate change on farmers
7. First individual genome sequence published
8. Springer increases publishing activities in South Korea
9. Springer will publish Journal of Coastal Conservation
10. Institution of Chemical Engineers chooses Elsevier as publishing partner
11. New tarpon, bonefish compendium published
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access ... 15.1% over the next decade to reach approximately $1,580 million by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second ... a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, ... from US2020. , US2020’s mission is to change the trajectory of STEM education ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology: