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Experts from NYU Langone present new research at American College of Rheumatology 2013 Annual Meeting
Date:10/30/2013

ccounting For Parental Load and Identification of Multiple Risk Variants for Anti-Ro Congenital Heart Block Through High-Density Genotyping Of Immune-Related Loci

Presenter: Robert Clancy, PhD; Co-authors: Jill P. Buyon, MD; Nathalie Costedoat-Chalumeau, MD, PhD; Antonio Brucato, MD; Kateri Levesque, FRCP(C), FRCPC, MD; Vronique Ramoni, MD; Miranda C. Marion, MA; Mary Comeau, MA; Satria Sajuthi, MS; Paula S. Ramos, PhD; Robert P. Kimberly, MD; Timothy D. Howard, PhD; Carl D. Langefeld, PhD
Abstract: #2861
Wednesday, October 30, 2013 at 11:15A PDT

Fetuses of mothers who are otherwise healthy, or suffer from a rheumatic disease but have autoantibodies to SSA/Ro, are at risk for having permanent heart damage which may be fatal or require lifelong pacing. Prior genetic studies, as well as bench research, highlight injury secondary to an excessive immune response. The goal of this study was to determine the role of the genetic composition of the fetus while accounting for the maternal autoimmune disease load. An immunochip platform and association study were performed using subjects from an international cohort of US, France and Italy. The results yielded a panel of confirmed and newly identified risk genes. These genetic building blocks represent important milestones towards clarifying the mechanism by which these autoantibodies cause cardiac scarring a critical component to treatment/prevention strategies.

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For more information on abstracts, presentations and seminars, visit American College of Rheumatology Sessions 2013.


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Contact: Craig Andrews
craig.andrews@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

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