Navigation Links
Experts from NYU Langone present new research at American College of Rheumatology 2013 Annual Meeting

Experts from NYU Langone's Department of Medicine, Division of Rheumatology presented new research and participated in expert panel discussions at the American College of Rheumatology 2013 Annual Meeting in San Diego, CA, October 26-30.

"We are thrilled for the opportunity to present important findings that may lead to new therapies for several autoimmune and rheumatic conditions," said Jill P. Buyon, MD, professor and director, Department of Medicine, Division of Rheumatology at NYU Langone Medical Center. "This meeting provides an opportunity to contribute to the growing body of knowledge regarding inflammatory disease while collaborating with other leaders in the field to ensure information sharing among clinicians and ultimately help enhance patient care."

Significant research presentations from NYU Langone rheumatologists will include:

First Stage of a Simon's Two-Stage Optimal Approach Supports Placental Transfer of Hydroxychloroquine and a Reduced Recurrence Rate of the Cardiac Manifestations of Neonatal Lupus

Presenter: Peter M. Izmirly, MD; Co-Authors: Nathalie Costedoat-Chalumeau, MD, PhD; Amit Saxena, MD; Amanda Zink; Zoey A. Smith; Deborah Freidman, MD; Jill P. Buyon, MD
Abstract: #2830
Wednesday, October 30, 2013 at 9:00A PDT

Women with anti-Ro antibodies, an antibody present in both Systemic Lupus Erythematosus (SLE) and Sjogren's Syndrome, are faced with the possibility of having a child with a permanent and sometimes fatal heart condition. Women who have had one child with this heart problem are at high risk for having a second affected child. To date, no therapies have proven effective in prevention. Data generated at NYU Langone show promise for a drug called hydroxychloroquine (HCQ), an anti-inflammatory agent, to prevent recurrent heart disease. If these findings are further substantiated, HCQ may gain widespread acceptance for use in these at risk pregnancies.

Learn More

Accounting For Parental Load and Identification of Multiple Risk Variants for Anti-Ro Congenital Heart Block Through High-Density Genotyping Of Immune-Related Loci

Presenter: Robert Clancy, PhD; Co-authors: Jill P. Buyon, MD; Nathalie Costedoat-Chalumeau, MD, PhD; Antonio Brucato, MD; Kateri Levesque, FRCP(C), FRCPC, MD; Vronique Ramoni, MD; Miranda C. Marion, MA; Mary Comeau, MA; Satria Sajuthi, MS; Paula S. Ramos, PhD; Robert P. Kimberly, MD; Timothy D. Howard, PhD; Carl D. Langefeld, PhD
Abstract: #2861
Wednesday, October 30, 2013 at 11:15A PDT

Fetuses of mothers who are otherwise healthy, or suffer from a rheumatic disease but have autoantibodies to SSA/Ro, are at risk for having permanent heart damage which may be fatal or require lifelong pacing. Prior genetic studies, as well as bench research, highlight injury secondary to an excessive immune response. The goal of this study was to determine the role of the genetic composition of the fetus while accounting for the maternal autoimmune disease load. An immunochip platform and association study were performed using subjects from an international cohort of US, France and Italy. The results yielded a panel of confirmed and newly identified risk genes. These genetic building blocks represent important milestones towards clarifying the mechanism by which these autoantibodies cause cardiac scarring a critical component to treatment/prevention strategies.

Learn More

For more information on abstracts, presentations and seminars, visit American College of Rheumatology Sessions 2013.


Contact: Craig Andrews
NYU Langone Medical Center / New York University School of Medicine

Related biology news :

1. Worlds leading coral experts to gather in Australia
2. Smell and taste experts to discuss new discoveries
3. Coral reef experts to present latest coral reef science during July symposium
4. Divide the Antarctic to protect native species, propose experts
5. World experts meet in Edinburgh to consider how life experiences impact on our genes
6. Major migration of bird experts flock to Vancouver
7. Experts propose cyber war on cancer
8. World experts enlist to help Malaysia mitigate problem of poorer nutrition as incomes rise
9. The IPCC Report on Climate Change - Swedish professor Thomas Sterner selected as 1 of the experts
10. Leader experts in neurorehabilitation gather in Toledo, Spain
11. Preserve the services of mangroves -- Earths invaluable coastal forests, experts urge
Post Your Comments:
(Date:10/29/2015)... LA JOLLA, Calif. , Oct. 29, 2015 /PRNewswire-USNewswire/ ... released a new report titled, "DNA Synthesis and Biosecurity: ... how well the Department of Health and Human Services ... was issued in 2010. --> ... advances, but it also has the potential to pose ...
(Date:10/29/2015)... BOSTON , Oct. 29, 2015  Connected health ... phenomena driving the explosion of technology-enabled health and wellness, ... his new book, The Internet of Healthy ... apps, sensors or smartphones even existed, Dr. Kvedar, vice ... model of health care delivery, moving care from the ...
(Date:10/27/2015)... YORK , Oct. 27, 2015 In ... major issues of concern for various industry verticals such ... is due to the growing demand for secure & ... in various ,sectors, such as hacking of bank accounts, ... for electronic equipment such as PC,s, laptops, and smartphones ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica Richman and Zachary ... in their initial angel funding process. Now, they are paying it forward to ... early stage investments in the microbiome space. In this, they join other ...
(Date:11/24/2015)... 2015 /CNW/ - iCo Therapeutics ("iCo" or "the Company") ... for the quarter ended September 30, 2015. Amounts, ... and presented under International Financial Reporting Standards ("IFRS"). ... said Andrew Rae , President & CEO ... not only value enriching for this clinical program, ...
(Date:11/24/2015)... -- --> --> ... Market by Product & Services (Primer, Probe, Custom Oligos, ... End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) - Global ... expected to reach USD 1,918.6 Million by 2020 from ... 10.1% during the forecast period. Browse 183 ...
(Date:11/24/2015)... TEL AVIV, Israel , Nov. 24, 2015  Tikcro Technologies Ltd. ... be held on December 29, 2015 at 11:00 a.m. Israel ... & Co., Electra Tower, 98 Yigal Allon Street, 36 th Floor, ... , election of Eric Paneth and Izhak Tamir ... and Rami Skaliter as external directors; , approval of an ...
Breaking Biology Technology: