Navigation Links
Experimental vaccine protects monkeys against chikungunya
Date:3/4/2010

hikungunya, and we badly need to develop an effective human vaccine for this virus."

To create the virus-like particles used in the experimental vaccine, the researchers used genetic engineering techniques to produce the structural proteins that produce the spiky, roughly spherical exterior possessed by chikungunya viruses before they have entered a cell. The proteins then assembled themselves into harmless balls that resembled particles of Sindbis virus a relative of chikungunya and a fellow member of the alphavirus genus, which also includes a number of insect-borne viruses capable of causing dangerous encephalitis in humans.

Serum drawn from rhesus macaques injected with the virus-like particles contained substantial levels of antibodies that inactivated chikungunya virus. Two groups of macaques were then inoculated, either with virus-like particles or with a sham solution containing no vaccine. When the researchers challenged the monkeys by injection with chikungunya 15 weeks later, they found that the vaccine had completely protected the animals from the virus.

Dr.Gary Nabel, director of the NIAID's Vaccine Research Center and corresponding author on the Nature Medicine paper, said that the vaccine's effectiveness against chikungunya had led his group to plan follow-up investigations into whether the same approach would work against other alphaviruses, such as Western and Eastern equine encephalitis viruses (both responsible for periodic outbreaks in the United States), and Africa's o'nyong-nyong virus.


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related biology news :

1. Experimental drug shows promise against brain, prostate cancers
2. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize 2009
3. Experimental treatments restore partial vision to blind people
4. Experimental treatment halts hypoxic-ischemic brain injury in newborns
5. 40 minority scientists receive travel fellowships to Experimental Biology 2009 in New Orleans
6. Survival in a Changing World: The Journal of Experimental Biology 2009 symposium
7. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize
8. Experimental chemotherapy regimen shows promise in treating advanced lung cancer
9. Experimental Biology and Medicine announces expansion into Asia, opens new office
10. Translational research patented first experimental treatment against idiopathic pulmonary fibrosis
11. Experimental Biology 2008 meets in San Diego April 5-9
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... Dec. 2, 2014   Marvin Test Solutions ... test solutions for military, aerospace, and manufacturing organizations, ... its successful TS-900 PXI semiconductor test platform ... of high-end systems to customers at a fraction ... to traditional ATE. "Our semiconductor ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... A molecule that helps the body's motor nerve cells ... a major role in inhibiting spinal-cord neurons from regenerating ... found. In cultured cells, the researchers found that a ... stabilizes long nerve fibers in adult vertebrates ?chemically blocks ...
... researchers first to report function of tunneling nanotubules , ... an extensive network of tiny tunnels that, like a ... signals to distant cells. This surprising discovery, being reported ... in the September issue of the journal Immunity, may ...
... seeking ways to eliminate pollution from waterways with microbes ... freshwater ponds can generate electricity. They present their findings ... Society for Microbiology. , "The bacteria are capable of ... to operate small electronic devices. As long as the ...
Cached Biology News:Researchers find molecule that inhibits regrowth of spinal nerve cells 2Researchers find molecule that inhibits regrowth of spinal nerve cells 3'Underground' tunnels discovered as means for communication between immune system cells 2'Underground' tunnels discovered as means for communication between immune system cells 3'Underground' tunnels discovered as means for communication between immune system cells 4Pollution-eating bacteria produce electricity 2
(Date:12/19/2014)... LayerBio is an MIT spin-off developing novel ... National Eye Institute (NEI) at the National Institutes of ... grant to develop a drug-eluting intraocular lens (IOL) for ... of vision loss in people over age 40 and ... Ken Mandell, LayerBio’s Founder and CEO, "There is a ...
(Date:12/19/2014)... In contrast to traditional LED lights where the ... uses proprietary LED technology to incorporate their spectra in ... is critical in low proximity installations. The Valoya L-series ... lifetime which is up to four times longer than ... cost was clearly higher when compared to traditional fluorescent ...
(Date:12/19/2014)... Egenix, Inc. is pleased to announce that Lionel Goldfrank ... succeed Donald Fresne ; Mr. Fresne has also resigned ... of the Board.  In recognition of the many contributions and ... twenty years, the Board designated Mr. Fresne as Chairman Emeritus. ... Search Committee to find a suitable replacement with Biotech industry ...
(Date:12/17/2014)... Based on the revenues gained ... market is dominated by four major players contributing ... These players include GE Healthcare (U.K.), Siemens AG ... , Full Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html ... be attributed to its strong product portfolio, which ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... (Nasdaq: VRUS ), a clinical stage pharmaceutical ... to treat viral infections, reported financial results and operational ... Financial Results Revenues were $1.9 million during the ... for the quarter ended March 31, 2008 and reflect ...
... Iceland, May 11 deCODE genetics,(Nasdaq: DCGN ) ... March 31, 2009. A conference call to discuss these ... webcast live tomorrow,Tuesday, May 12, at 8:00am Eastern Daylight ... Net loss for the quarter ended ...
... MOUNTAIN VIEW, Calif., May 11 VIVUS, Inc. (Nasdaq: ... and commercialization of novel therapeutic products, today reported its highlights and ... First Quarter 2009 Highlights: , ... European Patent for Qnexa - In January 2009, we announced ...
Cached Biology Technology:Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 2Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 3Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 4Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 5Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 6Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 7Pharmasset Reports Fiscal Second Quarter 2009 Financial Results 8deCODE genetics Announces First Quarter 2009 Financial Results 2deCODE genetics Announces First Quarter 2009 Financial Results 3deCODE genetics Announces First Quarter 2009 Financial Results 4deCODE genetics Announces First Quarter 2009 Financial Results 5deCODE genetics Announces First Quarter 2009 Financial Results 6deCODE genetics Announces First Quarter 2009 Financial Results 7deCODE genetics Announces First Quarter 2009 Financial Results 8VIVUS Reports First Quarter 2009 Financial Results and Highlights 2VIVUS Reports First Quarter 2009 Financial Results and Highlights 3VIVUS Reports First Quarter 2009 Financial Results and Highlights 4VIVUS Reports First Quarter 2009 Financial Results and Highlights 5VIVUS Reports First Quarter 2009 Financial Results and Highlights 6VIVUS Reports First Quarter 2009 Financial Results and Highlights 7
... siRNA library screening, optimal siRNA ... and verified for each cell ... siRNA Transfection Optimization Kit, which ... transfection conditions in 96 well ...
... Series of positioning slides offers multiple ... leadscrew, micrometer, and manual. With this ... cost-effective multi-axis systems. These slides also ... resolutions down to 10 nanometers, integrated ...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
Biology Products: