Navigation Links
Experimental treatment halts hypoxic-ischemic brain injury in newborns
Date:7/29/2009

neonatal cerebral hypoxic-ischemia, according to the researchers. The enzyme in this case, tPA, normally breaks down proteins and other molecules to eliminate blood clots.

The current study, posted on the journal's website this month, included one-week-old rats in which brain hypoxia-ischemia was induced. The researchers found that hypoxia-ischemia leads to increased tPA activity. The enzyme then damages the brain blood vessels and the blood-brain barrier. The blood-brain barrier is a protective system designed to prevent invasions of blood-borne materials, in particular inflammatory cells or potential contaminants, into the central nervous system.

Dr. Kuan and his colleagues report that elevated tPA activity is triggered earlier in brain hypoxia than other proteases, particularly matrix metalloproteinases, in the progressive molecular process that leads to brain injury. This makes it a better target for therapeutic intervention to shut down the injury process early.

To test the importance of plasminogen activator in HIE, the research team examined the therapeutic effect of injecting PAI-1 into newborn rats suffering from the brain blood flow reduction and systemic hypoxia. The enzyme inhibitor was injected into the intracerebroventricular region of the brain, which includes a system of canals that distribute cerebrospinal fluid throughout the organ.

The researchers found that injection of PAI-1 greatly reduced the activity of both tPA and another brain enzyme, urokinase-type plasminogen activator. It also blocked hypoxic-ischemia-induced activation of matrix metalloproteinases and damage to the blood-brain barrier. The researchers also applied magnetic resonance imaging tests and microscopic analysis of brain tissues, which showed that PAI-1 treatment greatly reduced brain edema, axonal degeneration and the loss of brain tissue.

Dr. Kuan said additional studies are needed to test the effectiveness and safety of PAI-1 t
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. 40 minority scientists receive travel fellowships to Experimental Biology 2009 in New Orleans
2. Survival in a Changing World: The Journal of Experimental Biology 2009 symposium
3. French scientist wins the Journal of Experimental Biology Outstanding Paper Prize
4. Experimental chemotherapy regimen shows promise in treating advanced lung cancer
5. Experimental Biology and Medicine announces expansion into Asia, opens new office
6. Translational research patented first experimental treatment against idiopathic pulmonary fibrosis
7. Experimental Biology 2008 meets in San Diego April 5-9
8. Discovery to aid in future treatments of third-world parasites
9. ISU researchers find possible treatment for spinal muscular atrophy
10. Promising new treatment for Alzheimers suggested based on Hebrew University research
11. New technique can fast-track better ionic liquids for biomass pre-treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... in December 2014, the 1U™ app has helped ... remember their usernames and passwords through replacing the antiquated system ... people who have struggled to remember usernames and passwords, ... on redefining identity, announced today that it is offering the ...
(Date:12/22/2014)...  The 2014 Holiday Season may be the brightest ever ... that the long anticipated floodgates for consumer biometrics may ... smart phones, tablets, and wearable mobile devices that incorporate ... users with nearly 4.8 billion biometric devices by 2020.   ...
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... pioneer on synthetic biology who has engineered microbial "factories" ... drug and biofuel substitutes for gasoline, diesel and jet ... presented by the Heinz Family Foundation and carries with ... multiple titles, Keasling is the Associate Laboratory Director for ...
... research indicates marijuana-like compounds called endocannabinoids alter genes and ... placenta during pregnancy and may contribute to pregnancy complications ... edition of The Journal of Biological Chemistry ... lipid molecules produced by the body disrupts the movement ...
... A team of Australian researchers, led by University of Melbourne ... the risk of developing Autism Spectrum Disorder, ASD. Lead ... Engineering at the University of Melbourne said the test could ... "This test could assist in the early detection of ...
Cached Biology News:Jay Keasling wins Heinz Award 2Jay Keasling wins Heinz Award 3Jay Keasling wins Heinz Award 4Study implicates marijuana use in pregnancy problems 2Genetic test predicts risk for Autism 2
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ...
(Date:12/24/2014)... SoundConnect’s 2015 next ... edge communication technology, provide continued education and inform ... series demonstrates online communication features and benefits; empowering ... most innovative and powerful tools. , According to ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... - Covance Inc. has promoted Wendel Barr to the ... Anthony Cork to the position of president, early development, ... move supports the regional decision-making employed by its clients ... Tony have become corporate senior vice presidents and also ...
... Plan of New Jersey and announced an investment to ... Insurance Corp., Delta Dental Plan of Michigan, The Guardian ... Providers (the dental subsidiary of UnitedHealth Group). , ,These ... to enhance a platform that allows dentists to submit ...
... with innovation and excitement on its closing day, focusing ... next-generation systems designed to protect and defend the national ... email services. In addition to an array of new ... next "big thing" in a morning panel devoted to ...
Cached Biology Technology:Covance Appoints Co-Presidents for Early Development Services 2DEMO 2003 Closes with Focus on Collaboration and Communication 2DEMO 2003 Closes with Focus on Collaboration and Communication 3DEMO 2003 Closes with Focus on Collaboration and Communication 4
Request Info...
Phospho-TAO2 (S181) Affinity Purified Polyclonal Ab Protein Family: Other Intracellular Kinases...
PEG 8000 is used in the precipitation of phage, isolation of plasmid DNA and the enhancement of blunt-ended ligation reactions....
Recombinant Mouse Matrilin-4, CF Protein Family: Extracellular Matrix Molecules, Chondrogenesis Markers...
Biology Products: